Rehabilitation Treatment for Adults with Post-Concussion Syndrome Using a Personalized Exercise Program

What this Trial Is About

Researchers are evaluating the effects of a personalized exercise program for adults with Post-Concussion Syndrome PCS, a condition involving long-lasting symptoms after a mild traumatic brain injury. The study explores PCS through patient experiences, a physical exercise intervention, neurobiological changes via MRI, and a comprehensive evaluation involving patients and scientists. It aims to better understand symptom patterns, physical capacity improvements, and brain changes related to PCS. The study has two groups one receiving usual care plus a 12-week individually tailored aerobic exercise program guided by symptoms and pulse rate, performed twice weekly with physiotherapist supervision the other group continues with usual care alone without added exercise. The exercise involves progressively increasing bike training intensity below symptom provocation thresholds. Usual care follows public healthcare standards. The study also includes qualitative interviews and MRI scans to assess brain function and structure. Participants will undergo clinical assessments before, during, and after the 12-week intervention, including the Buffalo Concussion Bike Test, symptom questionnaires, and weekly wellbeing tracking via SMS. MRI scans will measure blood-brain barrier permeability, brain metabolism, and microstructural changes. A final joint evaluation with patients and researchers will reflect on the projects strengths and weaknesses. The total participation lasts at least 12 weeks, with multiple scheduled clinical and imaging evaluations.

Rehabilitation in Post Concussion Syndrome