What is this study trying to find out about cancer pain management?

This study is evaluating whether an Internet-based pain coping skills program combined with enhanced usual care can reduce pain severity and interference in adult cancer survivors. Researchers also examine effects on medication use, quality of life, and emotional and cognitive factors. Wake Forest University Health Sciences is leading this research to improve pain management options for cancer survivors.

Who may be eligible for this cancer clinical trial?

Adults aged 18 years or older who have been treated for invasive cancer and are experiencing persistent pain related to cancer or its treatment may be eligible. Participants must have stable pain medication use if applicable and be able to complete study activities in English. Please review eligibility criteria for more details.

Is there any cost to participate in this cancer clinical trial?

Study-related care, including the study program and all trial visits, is provided at no cost. However, personal travel expenses to attend visits may vary and are not guaranteed to be covered. Participants should consider these potential costs when deciding to join.

Actively Recruiting

Phase Not Applicable

Age: 18Years +

All Genders

ID04462302

Internet-delivered Management of Pain Among Cancer Treatment Survivors

Led by Wake Forest University Health Sciences · Updated on 2026-01-29

456

Participants Needed

150

Research Sites

52 weeks

Total Duration

AI-Summary

What this Trial Is About

Researchers are evaluating an Internet-based pain coping skills program combined with enhanced usual care to see if it improves pain severity and pain interference in adult cancer survivors with persistent cancer-related pain. This study also looks at other effects such as opioid medication use, quality of life, pain management confidence, fatigue, sleep, emotional distress, positive feelings, pain impact, cognitive problems, and cognitive performance. The study enrolls 250 participants who have been treated for invasive cancer and are experiencing ongoing pain. Participants are randomly assigned to one of two groups. One group receives access to an 8-session online pain coping program plus pain education alongside their usual care, which they complete within 10 weeks and can revisit during that time. After the study ends, they retain access to the program. The other group receives pain education only at their initial clinic visit and will be offered access to the online program after completing the 6-month follow-up assessment. Each participant is involved in the study for about 9 months, from randomization through final follow-up at week 34. Researchers will assess changes in pain severity and interference primarily from baseline to 10 weeks, with additional follow-ups at 22 and 34 weeks. They will also monitor opioid use, quality of life, and pain management self-efficacy. Participants complete various questionnaires and assessments throughout, and adherence to the online program is tracked. The study aims to better understand how this Internet-based approach may help manage cancer-related pain.

CONDITIONS

Brief Title

An Internet-based Program to Help Cancer Survivors Manage Pain

Who Can Participate

Age: 18Years +

All Genders

Eligibility Criteria

You may qualify if you...

Adults aged 18 years or older
Documented diagnosis of invasive cancer treated with surgery, radiation, chemotherapy, or similar therapies
May be off all treatment or actively receiving anticancer therapy without planned treatment changes during the study
If on therapy, must have been on current therapy for at least four weeks or off therapy for at least four weeks prior to enrollment
At least four weeks since major surgery and at least two weeks since minor surgery
No planned surgery or radiation during the 3-month intervention period
Less than or equal to 5 years since completion of anticancer therapy if no longer receiving treatment
Pain score of 4 or higher on PROMIS Pain Intensity scale
Score of "Most Days" or higher on the Graded Chronic Pain Scale Revised
Stable analgesic regimen for at least 14 days prior to enrollment without planned dose increases during the intervention period
Pain of new onset or significantly worsened since cancer diagnosis or treatment start
Expected ability to complete all study activities including follow-ups
ECOG performance status of 0, 1, or 2
Able to speak, read, and understand English

You will not qualify if you...

Disability preventing completion of study activities (e.g., severe vision or hearing loss, dementia, severe psychiatric disorder, or substance abuse)
Pain conditions unrelated to cancer or its treatment only (e.g., migraine, arthritis, fibromyalgia)
Diagnosed or suspected substance use disorder or opioid overuse disorder or currently treated for such
Currently prescribed buprenorphine or suboxone
Enrolled in hospice or end-of-life palliative care
No reliable Internet access or unwillingness to use Tablet Lending Program
No working email address

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

Your Study Journey

Screening

Duration - 2 to 4 weeks

Participants are screened for eligibility to participate in the trial.

1 visit (in-person)

Internet-based Pain Coping Skills Program

Duration - 10 weeks

Participants complete an 8-session Internet-based pain management program within 10 weeks, alongside pain education, to help manage cancer-related pain.

Participants access sessions online at their own pace over 10 weeks

Follow-up Assessments

Duration - Up to 34 weeks from enrollment

Participants complete follow-up assessments to track pain severity, pain interference, medication use, quality of life, and self-efficacy up to 34 weeks after starting the program.

Assessments at baseline, 10, 22, and 34 weeks

Trial Site Locations

Total: 150 locations

Mercy Hospital Fort Smith

Fort Smith, Arkansas, United States, 72903

Actively Recruiting

Kaiser Permanente-Deer Valley Medical Center

Antioch, California, United States, 94531

Actively Recruiting

Kaiser Permanente Dublin

Dublin, California, United States, 94568

Actively Recruiting

Kaiser Permanente-Fremont

Fremont, California, United States, 94538

Actively Recruiting

Kaiser Permanente-Fresno

Fresno, California, United States, 93720

Actively Recruiting

Kaiser Permanente-Modesto

Modesto, California, United States, 95356

Actively Recruiting

Kaiser Permanente-Oakland

Oakland, California, United States, 94611

Actively Recruiting

Kaiser Permanente- Marshall Medical Offices

Redwood City, California, United States, 94063

Actively Recruiting

Kaiser Permanente-Richmond

Richmond, California, United States, 94801

Actively Recruiting

Kaiser Permanente-Roseville

Roseville, California, United States, 95661

Actively Recruiting

Kaiser Permanente Downtown Commons

Sacramento, California, United States, 95814

Actively Recruiting

Kaiser Permanente-South Sacramento

Sacramento, California, United States, 95823

Actively Recruiting

Kaiser Permanente-San Francisco

San Francisco, California, United States, 94115

Actively Recruiting

Kaiser Permanente-Santa Teresa-San Jose

San Jose, California, United States, 95119

Actively Recruiting

Kaiser Permanente San Leandro

San Leandro, California, United States, 94577

Actively Recruiting

Kaiser San Rafael-Gallinas

San Rafael, California, United States, 94903

Actively Recruiting

Kaiser Permanente Medical Center - Santa Clara

Santa Clara, California, United States, 95051

Actively Recruiting

Kaiser Permanente-Santa Rosa

Santa Rosa, California, United States, 95403

Actively Recruiting

Kaiser Permanente-South San Francisco

South San Francisco, California, United States, 94080

Actively Recruiting

Kaiser Permanente-Stockton

Stockton, California, United States, 95210

Actively Recruiting

Kaiser Permanente Medical Center-Vacaville

Vacaville, California, United States, 95688

Actively Recruiting

Kaiser Permanente-Vallejo

Vallejo, California, United States, 94589

Actively Recruiting

Kaiser Permanente-Franklin

Denver, Colorado, United States, 80205

Actively Recruiting

Kaiser Permanente-Rock Creek

Lafayette, Colorado, United States, 80026

Actively Recruiting

Kaiser Permanente-Lone Tree

Lone Tree, Colorado, United States, 80124

Actively Recruiting

John B. Amos Cancer Center

Columbus, Georgia, United States, 31904

Actively Recruiting

Lewis Cancer and Research Pavilion at Saint Joseph's/Candler

Savannah, Georgia, United States, 31405

Actively Recruiting

Hawaii Cancer Care Inc - Waterfront Plaza