Actively Recruiting
An Internet-based Program to Help Cancer Survivors Manage Pain
Led by Wake Forest University Health Sciences · Updated on 2026-01-29
456
Participants Needed
150
Research Sites
367 weeks
Total Duration
On this page
Sponsors
W
Wake Forest University Health Sciences
Lead Sponsor
N
National Cancer Institute (NCI)
Collaborating Sponsor
AI-Summary
What this Trial Is About
To determine whether an Internet-based pain coping skills program plus enhanced usual care, compared to enhanced usual care alone, yields significant improvements in the co-primary outcomes of pain severity (as measured by the Brief Pain Inventory (BPI)) and pain interference (also measured by the BPI) from baseline to the post-intervention assessment for cancer survivors with persistent pain.
CONDITIONS
Official Title
An Internet-based Program to Help Cancer Survivors Manage Pain
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Must have a documented diagnosis of invasive cancer treated with surgery, radiation, chemotherapy, or other therapies
- May be off treatment or actively receiving anticancer therapy in adjuvant, maintenance, or active cancer settings
- Patients on current anticancer therapy must have no planned treatment changes during the intervention period
- Patients on therapy must have been on it for at least 4 weeks or off therapy for 4 weeks before enrollment
- At least 4 weeks must have passed since major surgery and 2 weeks since minor surgery before enrollment
- No planned surgery or radiation during the 3-month intervention period
- If no longer receiving anticancer therapy, must be within 5 years of therapy completion
- Must have pain with a score of at least 4 on PROMIS Pain Intensity scale
- Must have a score of "Most Days" or higher on the Graded Chronic Pain Scale Revised
- Stable analgesic regimen for at least 14 days before enrollment with no planned dose increases during intervention
- Pain must be new or significantly worsened since cancer diagnosis or treatment start
- Expected to complete all study activities including follow-ups at weeks 22 and 34
- ECOG performance status of 0, 1, or 2
- Age 18 years or older
- Able to speak, read, and understand English
You will not qualify if you...
- Disability preventing completion of study activities (e.g., severe vision/hearing loss, dementia, severe psychiatric disorder, substance abuse)
- Only preexisting pain unrelated to cancer or its treatment (e.g., migraines, arthritis, fibromyalgia)
- Known or suspected substance use disorder or opioid overuse disorder or currently treated for such
- Currently prescribed buprenorphine or suboxone
- Enrolled in hospice or end-of-life palliative care
- No reliable internet access or unwilling to use the Tablet Lending Program
- No working email address
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 150 locations
1
Mercy Hospital Fort Smith
Fort Smith, Arkansas, United States, 72903
Actively Recruiting
2
Kaiser Permanente-Deer Valley Medical Center
Antioch, California, United States, 94531
Actively Recruiting
3
Kaiser Permanente Dublin
Dublin, California, United States, 94568
Actively Recruiting
4
Kaiser Permanente-Fremont
Fremont, California, United States, 94538
Actively Recruiting
5
Kaiser Permanente-Fresno
Fresno, California, United States, 93720
Actively Recruiting
6
Kaiser Permanente-Modesto
Modesto, California, United States, 95356
Actively Recruiting
7
Kaiser Permanente-Oakland
Oakland, California, United States, 94611
Actively Recruiting
8
Kaiser Permanente- Marshall Medical Offices
Redwood City, California, United States, 94063
Actively Recruiting
9
Kaiser Permanente-Richmond
Richmond, California, United States, 94801
Actively Recruiting
10
Kaiser Permanente-Roseville
Roseville, California, United States, 95661
Actively Recruiting
11
Kaiser Permanente Downtown Commons
Sacramento, California, United States, 95814
Actively Recruiting
12
Kaiser Permanente-South Sacramento
Sacramento, California, United States, 95823
Actively Recruiting
13
Kaiser Permanente-San Francisco
San Francisco, California, United States, 94115
Actively Recruiting
14
Kaiser Permanente-Santa Teresa-San Jose
San Jose, California, United States, 95119
Actively Recruiting
15
Kaiser Permanente San Leandro
San Leandro, California, United States, 94577
Actively Recruiting
16
Kaiser San Rafael-Gallinas
San Rafael, California, United States, 94903
Actively Recruiting
17
Kaiser Permanente Medical Center - Santa Clara
Santa Clara, California, United States, 95051
Actively Recruiting
18
Kaiser Permanente-Santa Rosa
Santa Rosa, California, United States, 95403
Actively Recruiting
19
Kaiser Permanente-South San Francisco
South San Francisco, California, United States, 94080
Actively Recruiting
20
Kaiser Permanente-Stockton
Stockton, California, United States, 95210
Actively Recruiting
21
Kaiser Permanente Medical Center-Vacaville
Vacaville, California, United States, 95688
Actively Recruiting
22
Kaiser Permanente-Vallejo
Vallejo, California, United States, 94589
Actively Recruiting
23
Kaiser Permanente-Franklin
Denver, Colorado, United States, 80205
Actively Recruiting
24
Kaiser Permanente-Rock Creek
Lafayette, Colorado, United States, 80026
Actively Recruiting
25
Kaiser Permanente-Lone Tree
Lone Tree, Colorado, United States, 80124
Actively Recruiting
26
John B. Amos Cancer Center
Columbus, Georgia, United States, 31904
Actively Recruiting
27
Lewis Cancer and Research Pavilion at Saint Joseph's/Candler
Savannah, Georgia, United States, 31405
Actively Recruiting
28
Hawaii Cancer Care Inc - Waterfront Plaza
Honolulu, Hawaii, United States, 96813
Actively Recruiting
29
Queen's Cancer Cenrer - POB I
Honolulu, Hawaii, United States, 96813
Actively Recruiting
30
Queen's Medical Center
Honolulu, Hawaii, United States, 96813
Actively Recruiting
31
Straub Clinic and Hospital
Honolulu, Hawaii, United States, 96813
Actively Recruiting
32
University of Hawaii Cancer Center
Honolulu, Hawaii, United States, 96813
Actively Recruiting
33
Queen's Cancer Center - Kuakini
Honolulu, Hawaii, United States, 96817
Actively Recruiting
34
The Cancer Center of Hawaii-Liliha
Honolulu, Hawaii, United States, 96817
Actively Recruiting
35
Kaiser Permanente Moanalua Medical Center
Honolulu, Hawaii, United States, 96819
Actively Recruiting
36
Kapiolani Medical Center for Women and Children
Honolulu, Hawaii, United States, 96826
Actively Recruiting
37
Tripler Army Medical Center
Honolulu, Hawaii, United States, 96859
Actively Recruiting
38
Hawaii Cancer Care - Savio
‘Aiea, Hawaii, United States, 96701
Actively Recruiting
39
Hawaii Cancer Care - Westridge
‘Aiea, Hawaii, United States, 96701
Actively Recruiting
40
Pali Momi Medical Center
‘Aiea, Hawaii, United States, 96701
Actively Recruiting
41
The Cancer Center of Hawaii-Pali Momi
‘Aiea, Hawaii, United States, 96701
Actively Recruiting
42
The Queen's Medical Center - West Oahu
‘Ewa Beach, Hawaii, United States, 96706
Actively Recruiting
43
Carle BroMenn Outpatient Center
Bloomington, Illinois, United States, 61704
Actively Recruiting
44
Illinois CancerCare-Bloomington
Bloomington, Illinois, United States, 61704
Actively Recruiting
45
Illinois CancerCare-Canton
Canton, Illinois, United States, 61520
Actively Recruiting
46
Northwestern University
Chicago, Illinois, United States, 60611
Actively Recruiting
47
Carle at The Riverfront
Danville, Illinois, United States, 61832
Actively Recruiting
48
Carle on Vermilion
Danville, Illinois, United States, 61832
Actively Recruiting
49
Cancer Care Specialists of Illinois - Decatur
Decatur, Illinois, United States, 62526
Actively Recruiting
50
Decatur Memorial Hospital
Decatur, Illinois, United States, 62526
Actively Recruiting
51
Illinois CancerCare-Galesburg
Galesburg, Illinois, United States, 61401
Actively Recruiting
52
Carle Physician Group-Mattoon/Charleston
Mattoon, Illinois, United States, 61938
Actively Recruiting
53
Carle BroMenn Medical Center
Normal, Illinois, United States, 61761
Actively Recruiting
54
Carle Cancer Institute Normal
Normal, Illinois, United States, 61761
Actively Recruiting
55
Illinois CancerCare-Ottawa Clinic
Ottawa, Illinois, United States, 61350
Actively Recruiting
56
Illinois CancerCare-Pekin
Pekin, Illinois, United States, 61554
Actively Recruiting
57
Illinois CancerCare-Peoria
Peoria, Illinois, United States, 61615
Actively Recruiting
58
Illinois CancerCare-Peru
Peru, Illinois, United States, 61354
Actively Recruiting
59
Carle Cancer Center
Urbana, Illinois, United States, 61801
Actively Recruiting
60
Illinois CancerCare - Washington
Washington, Illinois, United States, 61571
Actively Recruiting
61
UI Health Care Mission Cancer and Blood - Ankeny Clinic
Ankeny, Iowa, United States, 50023
Actively Recruiting
62
Physicians' Clinic of Iowa PC
Cedar Rapids, Iowa, United States, 52402
Actively Recruiting
63
UI Health Care Mission Cancer and Blood - West Des Moines Clinic
Clive, Iowa, United States, 50325
Actively Recruiting
64
Medical Oncology and Hematology Associates-Des Moines
Des Moines, Iowa, United States, 50309
Actively Recruiting
65
Broadlawns Medical Center
Des Moines, Iowa, United States, 50314
Actively Recruiting
66
Mercy Medical Center - Des Moines
Des Moines, Iowa, United States, 50314
Actively Recruiting
67
UI Health Care Mission Cancer and Blood - Laurel Clinic
Des Moines, Iowa, United States, 50314
Actively Recruiting
68
UI Health Care Mission Cancer and Blood - Waukee Clinic
Waukee, Iowa, United States, 50263
Actively Recruiting
69
Flaget Memorial Hospital
Bardstown, Kentucky, United States, 40004
Actively Recruiting
70
Saint Joseph Radiation Oncology Resource Center
Lexington, Kentucky, United States, 40504
Actively Recruiting
71
Saint Joseph Hospital East
Lexington, Kentucky, United States, 40509
Actively Recruiting
72
Saint Joseph London
London, Kentucky, United States, 40741
Actively Recruiting
73
Ochsner Baptist Medical Center
New Orleans, Louisiana, United States, 70115
Actively Recruiting
74
Ochsner Medical Center Jefferson
New Orleans, Louisiana, United States, 70121
Actively Recruiting
75
CHRISTUS Highland Medical Center
Shreveport, Louisiana, United States, 71105
Actively Recruiting
76
MaineHealth Cancer Care Center of York County
Sanford, Maine, United States, 04073
Actively Recruiting
77
Trinity Health Saint Joseph Mercy Hospital Ann Arbor
Ann Arbor, Michigan, United States, 48106
Actively Recruiting
78
Trinity Health Medical Center - Brighton
Brighton, Michigan, United States, 48114
Actively Recruiting
79
Trinity Health Medical Center - Canton
Canton, Michigan, United States, 48118
Actively Recruiting
80
Chelsea Hospital
Chelsea, Michigan, United States, 48118
Actively Recruiting
81
Genesee Cancer and Blood Disease Treatment Center
Flint, Michigan, United States, 48503
Actively Recruiting
82
Genesee Hematology Oncology PC
Flint, Michigan, United States, 48503
Actively Recruiting
83
Genesys Hurley Cancer Institute
Flint, Michigan, United States, 48503
Actively Recruiting
84
Marshfield Medical Center Dickinson
Iron Mountain, Michigan, United States, 49801
Actively Recruiting
85
Trinity Health Saint Mary Mercy Livonia Hospital
Livonia, Michigan, United States, 48154
Actively Recruiting
86
Trinity Health Saint Joseph Mercy Oakland Hospital
Pontiac, Michigan, United States, 48341
Actively Recruiting
87
Mercy Hospital
Coon Rapids, Minnesota, United States, 55433
Actively Recruiting
88
Fairview Southdale Hospital
Edina, Minnesota, United States, 55435
Actively Recruiting
89
Saint John's Hospital - Healtheast
Maplewood, Minnesota, United States, 55109
Actively Recruiting
90
Abbott-Northwestern Hospital
Minneapolis, Minnesota, United States, 55407
Actively Recruiting
91
North Memorial Medical Health Center
Robbinsdale, Minnesota, United States, 55422
Actively Recruiting
92
Park Nicollet Clinic - Saint Louis Park
Saint Louis Park, Minnesota, United States, 55416
Actively Recruiting
93
Regions Hospital
Saint Paul, Minnesota, United States, 55101
Actively Recruiting
94
United Hospital
Saint Paul, Minnesota, United States, 55102
Actively Recruiting
95
Lakeview Hospital
Stillwater, Minnesota, United States, 55082
Actively Recruiting
96
Rice Memorial Hospital
Willmar, Minnesota, United States, 56201
Actively Recruiting
97
Minnesota Oncology Hematology PA-Woodbury
Woodbury, Minnesota, United States, 55125
Actively Recruiting
98
Central Care Cancer Center - Bolivar
Bolivar, Missouri, United States, 65613
Actively Recruiting
99
Heartland Regional Medical Center
Saint Joseph, Missouri, United States, 64506
Actively Recruiting
100
CentraState Medical Center
Freehold, New Jersey, United States, 07728
Actively Recruiting
101
Hackettstown Medical Center
Hackettstown, New Jersey, United States, 07840
Actively Recruiting
102
Morristown Medical Center
Morristown, New Jersey, United States, 07960
Actively Recruiting
103
Saint Peter's University Hospital
New Brunswick, New Jersey, United States, 08901
Actively Recruiting
104
Newton Medical Center
Newton, New Jersey, United States, 07860
Actively Recruiting
105
Chilton Medical Center
Pompton, New Jersey, United States, 07444
Actively Recruiting
106
Overlook Medical Center
Summit, New Jersey, United States, 07901
Actively Recruiting
107
Wake Forest University at Clemmons
Clemmons, North Carolina, United States, 27012
Actively Recruiting
108
Wake Forest University at Lexington
Lexington, North Carolina, United States, 27292
Actively Recruiting
109
Wake Forest University Health Sciences
Winston-Salem, North Carolina, United States, 27157
Actively Recruiting
110
The Mark H Zangmeister Center
Columbus, Ohio, United States, 43219
Actively Recruiting
111
Memorial Hospital
Marysville, Ohio, United States, 43040
Actively Recruiting
112
Knox Community Hospital
Mount Vernon, Ohio, United States, 43050
Actively Recruiting
113
Southern Ohio Medical Center
Portsmouth, Ohio, United States, 45662
Actively Recruiting
114
Geisinger Medical Center
Danville, Pennsylvania, United States, 17822
Actively Recruiting
115
Geisinger Medical Center-Cancer Center Hazleton
Hazleton, Pennsylvania, United States, 18201
Actively Recruiting
116
Geisinger Medical Oncology-Lewisburg
Lewisburg, Pennsylvania, United States, 17837
Actively Recruiting
117
Geisinger Cancer Services-Pottsville
Pottsville, Pennsylvania, United States, 17901
Actively Recruiting
118
Community Medical Center
Scranton, Pennsylvania, United States, 18510
Actively Recruiting
119
Geisinger Wyoming Valley/Henry Cancer Center
Wilkes-Barre, Pennsylvania, United States, 18711
Actively Recruiting
120
Saint Joseph's/Candler - Bluffton Campus
Bluffton, South Carolina, United States, 29910
Actively Recruiting
121
Prisma Health Cancer Institute - Spartanburg
Boiling Springs, South Carolina, United States, 29316
Actively Recruiting
122
Medical University of South Carolina
Charleston, South Carolina, United States, 29425
Actively Recruiting
123
Prisma Health Cancer Institute - Easley
Easley, South Carolina, United States, 29640
Actively Recruiting
124
Tidelands Georgetown Memorial Hospital
Georgetown, South Carolina, United States, 29440
Actively Recruiting
125
Prisma Health Cancer Institute - Butternut
Greenville, South Carolina, United States, 29605
Actively Recruiting
126
Prisma Health Cancer Institute - Faris
Greenville, South Carolina, United States, 29605
Actively Recruiting
127
Prisma Health Cancer Institute - Eastside
Greenville, South Carolina, United States, 29615
Actively Recruiting
128
Self Regional Healthcare
Greenwood, South Carolina, United States, 29646
Actively Recruiting
129
Prisma Health Cancer Institute - Greer
Greer, South Carolina, United States, 29650
Actively Recruiting
130
South Carolina Cancer Specialists PC
Hilton Head Island, South Carolina, United States, 29926
Actively Recruiting
131
Prisma Health Cancer Institute - Seneca
Seneca, South Carolina, United States, 29672
Actively Recruiting
132
Peninsula Cancer Institute - Gloucester
Gloucester, Virginia, United States, 23061
Actively Recruiting
133
Peninsula Cancer Institute - Newport News
Newport News, Virginia, United States, 23601
Actively Recruiting
134
VCU Massey Cancer Center at Stony Point
Richmond, Virginia, United States, 23235
Actively Recruiting
135
Virginia Commonwealth University/Massey Cancer Center
Richmond, Virginia, United States, 23298
Actively Recruiting
136
VCU Community Memorial Health Center
South Hill, Virginia, United States, 23970
Actively Recruiting
137
Peninsula Cancer Institute - Cancer Specialists of Tidewater
Virginia Beach, Virginia, United States, 23235
Actively Recruiting
138
Peninsula Cancer Institute - Williamsburg
Williamsburg, Virginia, United States, 23185
Actively Recruiting
139
Marshfield Clinic-Chippewa Center
Chippewa Falls, Wisconsin, United States, 54729
Actively Recruiting
140
Marshfield Medical Center-EC Cancer Center
Eau Claire, Wisconsin, United States, 54701
Actively Recruiting
141
Marshfield Medical Center - Ladysmith
Ladysmith, Wisconsin, United States, 54848
Actively Recruiting
142
Marshfield Medical Center-Marshfield
Marshfield, Wisconsin, United States, 54449
Actively Recruiting
143
Marshfield Medical Center - Minocqua
Minocqua, Wisconsin, United States, 54548
Actively Recruiting
144
Marshfield Medical Center - Neillsville
Neillsville, Wisconsin, United States, 54456
Actively Recruiting
145
Marshfield Medical Center-Rice Lake
Rice Lake, Wisconsin, United States, 54868
Actively Recruiting
146
Marshfield Medical Center-River Region at Stevens Point
Stevens Point, Wisconsin, United States, 54482
Actively Recruiting
147
Marshfield Clinic-Wausau Center
Wausau, Wisconsin, United States, 54401
Actively Recruiting
148
Marshfield Medical Center - Weston
Weston, Wisconsin, United States, 54476
Actively Recruiting
149
Marshfield Clinic - Wisconsin Rapids Center
Wisconsin Rapids, Wisconsin, United States, 54494
Actively Recruiting
150
FHP Health Center-Guam
Tamuning, GU, Guam, 96913
Actively Recruiting
Research Team
K
Karen Craver
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
SUPPORTIVE_CARE
Number of Arms
2
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