Creating a Stem Cell Biobank and Blood Biomarker Database from Adults Aged 18 to 80 with Diverse Cardiovascular Diseases

What this Trial Is About

Researchers are creating a clinical database and a biobank of stem cells derived from blood samples of participants with cardiovascular disease. The study aims to include diverse racial and ethnic backgrounds with balanced representation from both sexes. The goal is to analyze blood for protein biomarkers and genetic causes of cardiovascular disease to better understand the disease mechanisms and identify new drug targets. This is an observational study collecting detailed clinical and molecular data to support future cardiovascular research. Participants will provide blood samples, which will be used to create induced pluripotent stem cells iPSCs. These iPSCs can produce cardiovascular tissue for research purposes. The study involves recruiting people with cardiovascular disease as well as healthy controls aged 80 and older with no known cardiovascular disease. Blood samples will also undergo DNA sequencing and serum protein biomarker analysis. All data and samples will be stored in a specialized laboratory for ongoing and future studies. During the study, participants clinical information will be collected and linked with molecular data including genetic sequencing and protein biomarker profiles. The primary outcomes include maintaining a REDCap database, establishing the iPSC biobank, differentiating cells into cardiovascular lineages, molecular profiling, and bioinformatics analysis over a 10-year period. This comprehensive approach supports long-term monitoring and research to advance understanding of cardiovascular diseases. Participation will involve blood collection and clinical data gathering with no investigational treatments administered.

iPSC Biobank of Biomarkers Diversity in Cardiovascular Disease