Actively Recruiting
Blood Biomarkers From Ethnically Diverse Cardiovascular Patients for iPSC Biobank and Molecular Profiling
Led by London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's · Updated on 2024-05-29
200
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
Sponsors
L
London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Lead Sponsor
G
Greenstone Biosciences, Inc.
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are creating a clinical database and a biobank of stem cells derived from blood samples of participants with cardiovascular disease. The study aims to include diverse racial and ethnic backgrounds with balanced representation from both sexes. The goal is to analyze blood for protein biomarkers and genetic causes of cardiovascular disease to better understand the disease mechanisms and identify new drug targets. This is an observational study collecting detailed clinical and molecular data to support future cardiovascular research. Participants will provide blood samples, which will be used to create induced pluripotent stem cells (iPSCs). These iPSCs can produce cardiovascular tissue for research purposes. The study involves recruiting people with cardiovascular disease as well as healthy controls aged 80 and older with no known cardiovascular disease. Blood samples will also undergo DNA sequencing and serum protein biomarker analysis. All data and samples will be stored in a specialized laboratory for ongoing and future studies. During the study, participants’ clinical information will be collected and linked with molecular data including genetic sequencing and protein biomarker profiles. The primary outcomes include maintaining a REDCap database, establishing the iPSC biobank, differentiating cells into cardiovascular lineages, molecular profiling, and bioinformatics analysis over a 10-year period. This comprehensive approach supports long-term monitoring and research to advance understanding of cardiovascular diseases. Participation will involve blood collection and clinical data gathering with no investigational treatments administered.
CONDITIONS
Brief Title
iPSC Biobank of Biomarkers Diversity in Cardiovascular Disease
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged 18 to 80 years
- Diagnosis of cardiovascular disease
- Includes cerebrovascular disease, peripheral vascular disease
- Includes inherited arrhythmias, cardiomyopathies
- Includes congenital heart disease and aortopathy
- Includes hypertension
- Includes cardiometabolic disease
You will not qualify if you...
- Younger than 18 years of age
- Unable to provide informed consent
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Single day
Blood samples are collected to create induced pluripotent stem cells (iPSCs) and to perform DNA sequencing and serum protein biomarker analysis.
1 visit (in-person)
Duration - Up to 10 years
Participants' clinical data, iPSC biobank, molecular profiling, and bioinformatics analyses are maintained and observed over time.
Data collection through clinical records; no additional visits required
Trial Site Locations
Total: 1 location
1
London Regional Health Science Centre
London, Ontario, Canada, N6A 5A5
Actively Recruiting
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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