Study of Immune Cells in Blood and Tissues After Allogeneic Hematopoietic Cell Transplant to Understand Chronic Graft-Versus-Host Disease

What this Trial Is About

Researchers are studying chronic graft-versus-host disease cGVHD, a complication that can follow allogeneic hematopoietic cell transplantation. This observational study aims to identify factors that contribute to cGVHD by analyzing immune cells and their subsets in patients who develop or do not develop this condition. Participants include those who have undergone the transplant with varying donor types and treatment regimens. Participants are assigned to one of two groups. Cohort 1 involves repeated collection of blood, saliva or buccal swabs, and stool samples for up to two years, along with ongoing review of medical records. Cohort 2 includes a one-time collection of these samples and medical record review. No treatments or interventions are administered as part of the study. During the study, participants provide biological samples and allow review of their clinical data. Researchers measure immune cells such as T cells, B cells, and macrophages over up to two years. This monitoring helps understand immune responses related to cGVHD. The study duration may last up to two years from enrollment, with ongoing assessments to evaluate immune cell kinetics.

Kinetic Analysis of Immune Cells in Blood and Chronic Graft-Versus-Host Disease-Affected Tissues After Allogeneic Hematopoietic Cell Transplantation