Actively Recruiting
Lifestyle Intervention Among Participants of the French Colorectal Cancer Screening Program (LIFE-SCREEN)
Led by Centre Leon Berard · Updated on 2026-05-05
800
Participants Needed
1
Research Sites
13 weeks
Total Duration
On this page
Sponsors
C
Centre Leon Berard
Lead Sponsor
I
International Agency for Research on Cancer
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are studying how giving advice on diet and lifestyle during colorectal cancer screening affects people at higher risk for colorectal cancer. This study focuses on individuals who have tested positive on a faecal immunochemical test (FIT), have adenomas, but do not have colorectal cancer. The goal is to develop and assess a lifestyle intervention based on recommendations from the World Cancer Research Fund and the French National Cancer Institute, aiming to improve adherence to healthy habits and quality of life. The study is a randomized controlled trial with two groups: one receiving usual care after screening and colonoscopy, and the other receiving usual care plus evidence-based diet and lifestyle advice. This advice will be delivered by health professionals through various materials like leaflets and digital information. The intervention and baseline measurements occur two to three weeks after colonoscopy. Data will be collected at baseline, 3, 6, and 12 months to measure changes in diet, lifestyle, quality of life, and body measurements. Participants will complete questionnaires about their lifestyle, health, and medical history at several time points. Anthropometric measurements will be taken at baseline and follow-up visits. The main outcome measured is how well participants stick to the recommended lifestyle changes after 3 months. The study will use both statistical and qualitative methods to analyze the results, which could provide valuable information for cancer prevention programs.
CONDITIONS
Brief Title
Lifestyle Intervention Among Participants of the French Colorectal Cancer Screening Program (LIFE-SCREEN)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Have read the information note and agree to participate
- Willing and available to commit for a full year
- At high risk for colorectal cancer but confirmed negative for colorectal cancer
- Affiliated to a health security system
- Have a baseline adherence score to recommendations of 7 or less out of 9
- Able to read, write, and understand French
You will not qualify if you...
- Following a strict diet such as meal replacements or diets for co-morbidities like diabetes
- Immobile due to physical constraints incompatible with physical activity
- Have had extensive intestinal surgery such as colectomy or colon resection
- Have chronic gastrointestinal illnesses like inflammatory bowel disease, irritable bowel syndrome, or celiac disease
- Have confirmed colorectal cancer or history of a primary cancer
- Suffering from severe malnutrition
- Pregnant
- Currently participating in another lifestyle study
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person) during colorectal cancer screening and colonoscopy
Duration - 12 months
Participants receive evidence-based diet and lifestyle advice or usual care following a positive faecal immunochemical test and diagnostic colonoscopy.
Baseline visit and follow-up visits at 3, 6, and 12 months
Trial Site Locations
Total: 1 location
1
Centre Léon Bérard
Lyon, France, France, 69008
Actively Recruiting
Research Team
I
Inge Huybretchts, PhD
G
Genevieve Nicolas, MSc
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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