Actively Recruiting
Local And Systemic Macrophage Activation in Coronary and Peripheral Artery Disease
Led by Maria Cecilia Hospital · Updated on 2026-05-14
60
Participants Needed
1
Research Sites
141 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Numerous clinical studies have highlighted the role of macrophages in the destabilization of coronary lesions; however, there is limited literature on the relationship between circulating monocytes and intraplaque macrophages. This study aims to evaluate and compare the presence of macrophages and their subsequent activation within coronary and peripheral atherosclerotic lesions, and to correlate these findings with the distribution of circulating monocyte subpopulations.
CONDITIONS
Official Title
Local And Systemic Macrophage Activation in Coronary and Peripheral Artery Disease
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients with chronic coronary artery disease
- Patients with no-ST elevation acute coronary syndrome
- Patients with chronic claudication (Rutherford II-III)
- Patients with critical limb ischemia (Rutherford IV-V)
You will not qualify if you...
- Severe renal dysfunction
- Severe valve disease
- Advanced heart failure
- Advanced liver disease
- Chronic inflammatory or autoimmune disease
- Use of antinflammatory drugs
- Acute infection
- Recent surgical procedures
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Maria Cecilia Hospital
Cotignola, Ravenna, Italy, 48033
Actively Recruiting
Research Team
R
Roberto Nerla, MD, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
DIAGNOSTIC
Number of Arms
4
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