Study of Macrophage Activation in Coronary and Peripheral Artery Disease Using Optical Coherence Tomography

What this Trial Is About

Researchers are investigating the role of macrophages in the instability of coronary artery lesions and how circulating monocytes relate to these macrophages. This study focuses on comparing macrophage presence and activation in both coronary and peripheral artery disease, aiming to understand their distribution in relation to monocyte subpopulations. The conditions studied include stable coronary artery disease, acute coronary syndromes, intermittent claudication, and critical limb ischemia. Participants will undergo Optical Coherence Tomography assessment, a diagnostic test that evaluates the number of infiltrating macrophages within atherosclerotic lesions. The study includes groups with different artery diseases such as stable coronary artery disease, acute coronary syndrome, intermittent claudication, and critical limb ischemia. This is a non-randomized interventional study without masking or placebo control. During the study, researchers will monitor the presence and activation of macrophages in coronary and peripheral lesions from enrollment until hospital discharge after angiography procedures. The main outcome measured is macrophage presence and activation in these lesions. Participants will be observed closely during this period to correlate these findings with circulating monocyte subpopulations. The total duration of participation spans from enrollment through the hospital stay following angiography.

Local And Systemic Macrophage Activation in Coronary and Peripheral Artery Disease