Lin Cang Shi

People with end stage kidney disease (ESKD) who require dialysis have a much higher risk of developing cardiovascular disease compared to the general population, with heart problems causing over half of the deaths in this group. This trial is studying whether taking low dose aspirin daily can safely reduce cardiovascular events in these dialysis patients. The study is a Phase 4, multi-center, randomized controlled trial designed to provide clear evidence about aspirin's benefits and risks in this specific population, where existing data is limited. Participants will be randomly assigned to receive either a daily 100 mg aspirin tablet or a matching placebo. The trial uses the Chinese peritoneal dialysis and hemodialysis registry to efficiently screen and recruit patients and collect data during routine dialysis care. Follow-up visits occur every six months as part of regular clinical care, and the study will continue until enough cardiovascular events have occurred, expected to take about five years. During the study, participants will have their health monitored through routine clinic visits every six months, with data collected on cardiovascular events and safety. The main outcome measured is the number of participants experiencing major cardiovascular events over the study period. An independent board will oversee safety and study progress. The trial uses intention-to-treat analysis and aims to minimize participant burden by integrating study procedures into usual care.

Researchers are evaluating an integrated child eye health service model in rural China that is centered at the county level and coordinated across county, township, village, and school levels. This study aims to assess how well this model works in real-world conditions by measuring its coverage and intensity, focusing on its impact on correcting refractive errors and referral rates after eye disease screening. The project also examines yearly trends in access disparities to different eye care services, aiming to improve pediatric eye disease management, visual function, and health equity in rural areas. The intervention involves annual, standardized school-based eye health screenings using tests such as visual acuity measurement, intraocular pressure using non-contact tonometry, and computerized autorefractor for refraction. Children with suspected strabismus or amblyopia may receive additional eye assessments, including smartphone-based digital tools. This service model also includes establishing a county-level referral system and enhancing ophthalmic service capacity in county hospitals to provide accessible, affordable, and high-quality care. Participants include children and adolescents aged 3 to 18 years enrolled in schools or residing permanently in selected counties of Guangdong and Yunnan provinces. During the study, researchers collect demographic and visual health data annually for up to three years, monitoring eye health screening coverage rates. Assessments include visual acuity tests and other eye examinations, with follow-up to track clinical outcomes. The study measures the effectiveness of the service model in preventing avoidable visual impairment and improving eye health outcomes over time.

Researchers are studying the effects of a six-month culturally adapted low glycemic index-high fiber (LGI-HF) diet on women with polycystic ovary syndrome (PCOS) living in remote areas of Yunnan Province. The study aims to see if this diet, designed to fit traditional high-carbohydrate eating habits and be easy to follow, can improve insulin resistance, hormone levels, and menstrual regularity. The goal is to provide practical, evidence-based guidance for managing PCOS long-term in resource-limited settings. This is a prospective, single-center intervention study lasting 24 weeks. Participants follow the LGI-HF diet, with evaluations conducted at the start, at 12 weeks, and at the end of the intervention. The diet is specifically adapted to be feasible and sustainable for women in mountainous regions of Yunnan. During the study, women will be monitored for insulin resistance using the HOMA-IR measure at 12 weeks, alongside assessments of metabolic and reproductive health. Participants are asked to keep their physical activity levels stable and stay within the study area for at least six months. Researchers will track adherence, menstrual patterns, hormone levels, and insulin resistance to evaluate the diet's effects and safety throughout the 24-week period.