Yi Li Ha Sa Ke Zi Zhi Zhou

Acute Aortic Syndrome (AAS) is a serious and life-threatening condition where inflammation significantly affects its development and progression, leading to high rates of death and complications. This research focuses on understanding how inflammation and anti-inflammatory treatments impact patients with AAS, particularly those undergoing surgery. The study is a large, long-term observational registry involving 20 cardiovascular centers in China, enrolling adult patients from 2016 through 2040 to investigate early and late outcomes related to inflammation. Participants in the study have undergone various treatments for AAS, including medical therapy, open surgery, endovascular repair, or hybrid procedures. The research collects detailed clinical data using specially designed forms and statistical analysis software to explore the role of inflammation and anti-inflammatory strategies alongside surgical repair. The registry also includes patients who had additional cardiac surgeries like coronary artery bypass or carotid artery replacement during their AAS treatment. During the study, researchers assess patients for severe inflammatory responses and organ function within the first week after surgery, and track outcomes such as mortality within 30 days, stroke, kidney injury, infections, bleeding, blood transfusions, and time spent in intensive care. The study aims to provide insights over 15 years on how inflammation affects recovery and long-term prognosis in AAS patients, helping to guide improved treatment strategies and reduce residual cardiovascular risks.

Primary aldosteronism (PA) is a common cause of secondary high blood pressure, but its best diagnosis and treatment methods are still difficult to establish. This research thoroughly evaluates adrenal venous sampling (AVS), focusing on important clinical, technical, and methodological questions. The goal is to understand how AVS-guided care affects long-term health and biochemical results to improve patient outcomes and management. The study involves patients with PA undergoing adrenal venous sampling through either the antecubital or femoral vein to identify whether aldosterone overproduction is coming from one side or both sides of the adrenal glands. This procedure helps classify the subtype of PA, which guides treatment decisions including potential adrenalectomy. The study also aims to refine AVS protocols and standardize clinical practice. Participants will be monitored for major adverse cardiovascular events (MACE) for one year after the AVS procedure. Researchers will assess clinical and biochemical outcomes to better understand the impact of AVS-guided management on patient prognosis. The study collects detailed information to optimize diagnosis, treatment decisions, and long-term care for individuals with primary aldosteronism.