Actively Recruiting
China Adrenal Venous Sampling Investigation: A National Multicenter Study
Led by Chinese Academy of Medical Sciences, Fuwai Hospital · Updated on 2025-11-26
5000
Participants Needed
76
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Primary aldosteronism (PA) is a common cause of secondary hypertension, and its diagnosis and treatment pose significant challenges. This research investigates adrenal venous sampling (AVS), which is considered the best method to distinguish between different types of PA. The study aims to address clinical, technical, and methodological questions about AVS and to understand how AVS-guided management influences long-term health and biochemical results to improve patient care. Participants with PA will undergo adrenal venous sampling through either the antecubital or femoral vein to identify whether aldosterone overproduction is unilateral or bilateral. This observational study evaluates the AVS procedure itself and its clinical outcomes, refining protocols and standardizing practices to optimize treatment decisions and patient prognosis. Throughout the study, researchers will monitor major cardiovascular events one year after AVS. They will also assess procedure success rates, complications, medication changes, blood pressure, heart and kidney function, and clinical outcomes over multiple years. The follow-up includes assessments at 1, 3, 6, 12, 18 months, and up to 10 years, enabling comprehensive evaluation of long-term effects and safety.
CONDITIONS
Brief Title
CHina Adrenal Venous saMPling InvestigatiON
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients with confirmed primary aldosteronism
- Patients undergoing adrenal venous sampling for subtype classification of primary aldosteronism
You will not qualify if you...
- Severe comorbidity within the past 3 months including stroke, myocardial infarction, heart failure, severe valvular heart disease, liver cirrhosis, or metastatic tumor
- Estimated glomerular filtration rate less than 45 ml/min/1.73 m2 or serum creatinine greater than 176 bcmol/L
- Patients who refuse adrenalectomy
- Suspected adrenocortical carcinoma
- Allergy to contrast agent
- Pregnant, nursing, or planning to become pregnant
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 1 day
Participants undergo adrenal venous sampling to differentiate forms of primary aldosteronism by assessing aldosterone production.
1 procedure visit (in-person)
Duration - Up to 10 years
Participants are monitored for clinical, biochemical outcomes, and major adverse cardiovascular events following adrenal venous sampling and treatment.
Multiple follow-up visits at 1, 3, 6, 12, and 18 months; and 2, 3, 4, 5, and 10 years after treatment
Trial Site Locations
Total: 76 locations
1
The first affiliated hospital of USTC
Hefei, Anhui, China, 230036
Actively Recruiting
2
Chuiyangliu Hospital affiliated to Tsinghua University
Beijing, Beijing Municipality, China, 100022
Actively Recruiting
3
China-Japan Friendship Hospital
Beijing, Beijing Municipality, China, 100029
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4
Peking University First Hospital
Beijing, Beijing Municipality, China, 100034
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5
Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College
Beijing, Beijing Municipality, China, 100037
Actively Recruiting
6
Peking University People's Hospital
Beijing, Beijing Municipality, China, 100044
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7
Beijing Luhe Hospital, Capital Medical University
Beijing, Beijing Municipality, China, 101100
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8
Chongqing University Central Hospital
Chongqing, Chongqing Municipality, China, 400000
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9
Chongqing General Hospital
Chongqing, Chongqing Municipality, China, 401147
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10
People's Hospital Affiliated to ChongqingThree Gorges Medical college
Chongqing, Chongqing Municipality, China, 404100
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11
First Affiliated Hospital, Fujian Medical University, Fuzhou, China,
Fuzhou, Fujian, China, 0591-87982222
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12
Cardiovascular Hospital Xiamen University
Xiamen, Fujian, China, 361016
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13
Lanzhou University Second Hospital
Lanzhou, Gansu, China, 730000
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14
The Forth People's Hosptal of Nanhai District of Foshan City
Foshan, Guangdong, China, 528211
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15
Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences)
Guangzhou, Guangdong, China, 510080
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16
Fuwai Hospital Chinese Academy of Medical Sciences, Shenzhen
Shenzhen, Guangdong, China, 518000
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17
Shenzhen Third People's Hospital，Shenzhen, Guangdong Province 518112, China
Shenzhen, Guangdong, China, 518112
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18
Shenzhen Dapeng New District Kuiyong People's Hospital
Shenzhen, Guangdong, China, 518116
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19
The First Affiliated Hospital of Guangxi Medical University
Nanning, Guangxi, China, 530000
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20
The Second Affliated Hospital Of GuangXi Medical Univesity
Nanning, Guangxi, China, 530007
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21
Nanning Third People's Hospital
Nanning, Guangxi, China, 547000
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22
Guizhou Provincial People's Hospital, Guiyang, Guizhou 550002, China.
Guiyang, Guizhou, China, 550002
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23
The Affiliated Hospital of Guizhou Medical University
Guiyang, Guizhou, China, 550004
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24
The Second Affiliated Hospital Of Guizhou Medical University
Kaili, Guizhou, China, 556000
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25
Hainan General Hospital, Department of Endocrinology
Haikou, Hainan, China, 570311
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26
Hainan General Hospital, Department of Cardiology
Hainan, Hainan, China, 570311
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27
Tangshan hongci Hospital
Tangshan, Hebei, China, 063000
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28
The First Affiliated Hospital of Harbin Medical University
Harbin, Heilongjiang, China, 150001
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29
The Second Affiliated Hospital of Harbin Medical University
Harbin, Heilongjiang, China, 150086
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30
Kai Feng the Peoples Hospital
Kaifeng, Henan, China, 475002
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31
Fuwai Central China Cardiovascular Hospital
Zhengzhou, Henan, China, 450000
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32
Henan Provincial People's Hospital
Zhengzhou, Henan, China, 450003
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33
Zhengzhou Central Hospital Affiliated to Zhengzhou University
Zhengzhou, Henan, China, 450007
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34
Zhengzhou Yihe Hospital
Zhengzhou, Henan, China, 450018
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35
The First Affiliated Hospital of Zhengzhou University
Zhengzhou, Henan, China, 450052
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36
Zhoukou Central Hospital
Zhoukou, Henan, China, 466000
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37
Renmin Hospital of Wuhan University
Wuhan, Hubei, China, 430060
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38
Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science
Xiangyang, Hubei, China, 441021
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39
Yichang Central People's Hospital
Yichang, Hubei, China, 43000
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40
Zhuzhou Hospital Affiliated to Xiangya School of Medicine,Central South University
Zhuzhou, Hunan, China, 412000
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41
Xuzhou Central Hospital, Jiangsu
Xuzhou, Jiangsu, China, 221009
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42
The First Affiliated Hospital of Gannan Medical University
Ganzhou, Jiangxi, China, 341000
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43
Second Affiliated Hospital of Nanchang University
Nanchang, Jiangxi, China, 330006
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44
Jiangxi Provincial People's Hospital (The First Affiliated Hospital of Nanchang Medical College)
Nanchang, Jiangxi, China, 330038
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45
The First Hospital of Jilin University
Changchun, Jilin, China, 130021
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46
Jilin Province FAW General Hospital
Changchun, Jilin, China, 130051
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47
Affilated Zhongshan Hospital of Dalian University
Dalian, Liaoning, China, 116001
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48
Frist Aiffiliated Hospital of Dalian Medical University
Dalian, Liaoning, China, 116011
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49
The second hospital of Dalian Medical University
Dalian, Liaoning, China, 116027
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50
Inner Mongolia Xing'an League People's Hospital
Ulanhot, Neimenggu, China, 137400
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51
The First People's Hospital of Yinchuan
Yinchuan, Ningxia, China, 750000
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52
Qinghai Province Cardiovascular and Cerebrovascular Disease Specialist Hospital
Xining, Qinghai, China, 810000
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53
Qinghai University Affiliated Hospital
Xining, Qinghai, China, 810001
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54
the Second Hospital, Cheeloo College of Medicine, Shandong University
Jinan, Shandong, China, 250000
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55
Qilu Hospital of Shandong University
Jinan, Shandong, China, 250012
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56
Central Hospital Affiliated to Shandong First Medical University
Jinan, Shandong, China, 250013
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57
People's Hospital of Donga County, Shandong Province
Liaocheng, Shandong, China, 252200
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58
Qingdao Hospital University of Health and Rehabilitation Sciences (Qingdao Municipal Hospital)
Qingdao, Shandong, China, 266000
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59
Shanghai Institute of Hypertension, Ruijin Hospital, Shanghai Jiaotong University School of Medicine
Shanghai, Shanghai Municipality, China, 200025
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60
Shanghai Putuo District Central Hospital
Shanghai, Shanghai Municipality, China, 200062
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61
Shanghai General Hospital ( originally named Shanghai First People's Hospital), Shanghai Jiao Tong University School of Medicine
Shanghai, Shanghai Municipality, China, 200080
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62
the second hospital of ShanXi medical unversity
Taiyuan, Shanxi, China, 030001
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63
Xi'an People's Hospital
Xi’an, Shanxi, China, 710018
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64
The Affiliated Hospital of Southwest Jiaotong University, The Third People's Hospital of Chengdu, Chengdu, China
Chengdu, Sichuan, China, 610031
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65
The First Affiliated Hospital of Chengdu Medical College
Chengdu, Sichuan, China, 610500
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66
Chengdu Fifth People's Hospital
Chengdu, Sichuan, China, 611130
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67
Tianjin Medical University General Hospital
Tianjin, Tianjin Municipality, China, 300052
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68
The Second Hospital of Tianjin Medical University
Tianjin, Tianjin Municipality, China, 300211
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69
TEDA International Cardiovascular Hospital
Tianjin, Tianjin Municipality, China, 300457
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70
Changdu People's Hospital of Tibet
Chamdo, Tibet, China, 854000
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71
Xinjiang Uygur Autonomous Region People's Hospital
Ürümqi, Xinjiang, China, 830001
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72
Yili Kazak Autonomous Prefecture Friendship Hospital
Yining, Xinjiang, China, 835000
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73
The First Affiliated Hospital of Kunming Medical University
Kunming, Yunnan, China, 650031
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74
Yan'an Affiliated Hospital of Kunming Medical University
Kunming, Yunnan, China, 650051
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75
Fuwai Yunnan Cardiovascular Hospital
Kunming, Yunnan, China, 650102
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76
Zhejiang Hospital
Hangzhou, Zhejiang, China, 310000
Actively Recruiting
Research Team
H
Hui Dong, MD
X
Xiongjing Jiang, MD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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