Ecully

This research aims to assess the safety and performance of Teknimed arthroplasty products, including the CEMFIX and GENTAFIX bone cement families and the CEMSTOP cement restrictor, which have been used for more than 20 years in joint replacement surgeries. The study focuses on real-life long-term data to confirm previous findings on these products safety and effectiveness in patients undergoing joint replacement due to osteoarthritis, osteonecrosis, trauma, or revision surgeries. The study is a global, multicenter, observational trial that collects both retrospective and prospective data from patients receiving primary or revision joint replacements involving Teknimed bone cements and cement restrictors. Different groups include patients undergoing knee, hip, or shoulder surgeries with various cement types. Patients receive treatment as part of their standard medical care, without additional interventions mandated by the study. Participants will be monitored according to local medical practices, with data collected on outcomes such as implant survival, infection rates, pain levels, patient satisfaction, function restoration, complications, and adverse events. The primary outcomes cover up to 15 years, focusing on device lifetime and postoperative infections, while secondary outcomes evaluate patient-reported and clinical measures over five years. This long-term follow-up aims to provide comprehensive safety and performance information for these arthroplasty products.

Researchers are investigating early maladaptive patterns in healthcare professionals experiencing burnout compared to those without burnout and non-care professionals with burnout. This observational, multicenter study in France aims to understand how these early patterns differ and may relate to burnout symptoms and vulnerability. The study will help identify potential targets for therapeutic intervention in burned-out healthcare workers. Participants are divided into three groups care professionals with burnout, care professionals without burnout, and non-care professionals with burnout. The study uses assessments such as the Young Schema Questionnaire Short form, Maslach Burnout Inventory, Montgomery-Asberg depression rating Scale, and White Bear Suppression Inventory to compare maladaptive schemas and burnout profiles. Data collection and participant inclusion occur during outpatient and occupational medicine consultations. During the study, participants complete questionnaires assessing burnout, depression, and maladaptive schemas over a 21-day period. Researchers will analyze these scores to understand differences between groups. The study involves telephone contact for some participants and data collection during routine occupational health visits. Participation includes informed consent and continuous monitoring, with the study expected to complete by the end of 2026.

Researchers are studying the early and advanced onset of puberty in children, focusing on the increasing age of puberty signs observed in the United States and Europe. This observational study aims to understand the causes behind these changes, including environmental endocrine disruptors and nutritional factors, by establishing a national observatory in collaboration with pediatric endocrinologists. The study targets children experiencing early signs of puberty to supplement existing epidemiological data that is currently limited. The study includes three groups based on puberty development children with suspected precocious puberty girls under 8 years, boys under 9 years, children with suspected advanced puberty girls 8 to under 10 years, boys 9 to under 11 years, and a control group of children without signs of puberty development Tanner stage 1. Participants are seen by pediatric endocrinologists during consultations, and their data is collected over a period of up to 48 months. Participants will be involved through consultations where data on their pubertal development is gathered. Researchers will monitor the number of patients recruited, the completeness of collected data, and the inclusion rate of eligible patients. The study plans to reach at least 75% patient inclusion and collect at least 80% of the main data during the observation period. The total study duration extends up to 48 months, allowing thorough follow-up and data analysis to better understand puberty timing changes.

Researchers are evaluating two surgical methods for treating grade II and III internal haemorrhoidal disease, particularly when other medical or instrumental treatments have not worked. This study compares Doppler-Guided Haemorrhoidal Artery Ligation DGHAL combined with mucopexy against a newer technique called radiofrequency ablation RFA. The aim is to assess whether RFA is not worse than DGHAL in terms of failure rates one year after surgery. The study involves two groups one receiving the DGHAL procedure, which uses a Doppler probe to locate and tie off haemorrhoidal arteries and includes folding the rectal mucosa mucopexy to treat prolapse the other group receives RFA, where a metal probe delivers radiofrequency energy to haemorrhoidal veins to sclerose them. Each haemorrhoidal bundle is treated individually. Both procedures are minimally invasive alternatives to traditional haemorrhoidectomy. Participants will be monitored for one year after surgery to measure the failure rate of the procedures. Researchers will evaluate symptom improvements and recurrence rates. The study includes adults aged 18 to 80 with symptomatic grade II or III haemorrhoidal disease requiring surgery. Participants must provide informed consent and be affiliated with the social security system. Safety and effectiveness will be assessed throughout the follow-up period.

Researchers are studying the potential benefits of outpatient care for patients with acute uncomplicated appendicitis treated by laparoscopic appendectomy. This research aims to compare outpatient care with conventional hospital care to see if outpatient care is not worse in terms of overall morbidity and mortality within 30 days after surgery. The study is motivated by the need to optimize care pathways, reduce hospital stays, improve patient satisfaction, and lower healthcare costs, especially important during the COVID-19 pandemic. The trial compares two treatment groups one receiving ambulatory appendectomy where surgery is done in an outpatient surgery unit and patients are discharged the same day, and the other receiving conventional appendectomy where surgery occurs in the digestive surgery department and patients stay overnight for observation before discharge. The study evaluates outcomes up to 30 days after surgery, including hospital stay length, rehospitalization rates, complications, re-interventions, patient satisfaction, quality of life, and economic impacts. Participants will undergo assessments before and after surgery, with monitoring of clinical outcomes, patient satisfaction, and quality of life at 7 and 30 days post-operation. Researchers will also track safety, the rate of conversion from outpatient to conventional care, and costs associated with each care pathway. The total study participation includes follow-up for 30 days after surgery to assess the main and secondary outcomes.