Gometz Le Chatel

Researchers are investigating social cognition, which is the ability to understand and respond to social information, in patients with drug-resistant medial temporal lobe epilepsy. This condition can impair social cognition, leading to a reduced quality of life. The study aims to map the structure and function of the social cognition network in 20 healthy individuals and 20 patients before and one year after epilepsy surgery to better understand how these networks are affected and reorganized. Participants will undergo detailed neuropsychological testing using a validated French assessment tool for social cognition. Brain scans will be performed using a 3-Tesla MRI to examine brain structure and white matter tracts involved in social cognition, and a 7-Tesla MRI to assess brain activity at rest and during social cognition tasks. These assessments will be done before surgery and repeated one year after surgery to observe changes. During the study, participants will have clinical and cognitive evaluations, along with advanced MRI scans to measure brain structure and function. Researchers will analyze changes in white matter tracts and brain activation related to social cognition. The primary outcomes include measures of brain tract integrity and functional MRI signals, with follow-up assessments to monitor network reorganization after epilepsy surgery. The total study duration extends to at least one year post-surgery.

Researchers are investigating the brain structure, connectivity, and function in people with autism spectrum disorder ASD, their relatives, and typically developing individuals. This study is part of a larger project examining genetic factors involved in ASD and related conditions. The goal is to find unique brain features linked to ASD, understand familial patterns, and connect brain imaging results with genetic data. Participants will undergo various types of magnetic resonance imaging MRI scans, including anatomical, diffusion, and functional MRI. These scans are done once at the start of the study to collect detailed brain images. The study includes people with ASD, their family members, and control subjects without ASD, all of whom are part of the main genetic study on ASD. During the study, participants will complete MRI scans that provide data on brain structure and activity. Researchers will analyze these images alongside genetic information to explore differences and patterns. The study involves informed consent, and participants are monitored for safety, including screening for MRI suitability. The total involvement focuses on the imaging session and data collection at one time point.

Researchers are investigating motor function and brain reorganization in stroke patients using advanced ultra high-field MRI technology. This study aims to develop a detailed brain atlas by combining structural and functional MRI data from 100 stroke patients to better understand how motor deficits relate to brain connectivity. The research uses machine learning to analyze brain activity and motor task performance, with the goal of improving neuroprosthesis placement for future stroke rehabilitation trials. Participants undergo task-based and resting-state functional MRI sessions that include motor imagery and motor execution tasks. These scans, performed on 3T and 7T MRI machines, collect detailed brain activity and structural data. The study includes both patients with chronic ischemic stroke and healthy volunteers. The data will be analyzed to predict individual motor action intentions and explore patterns of brain reorganization. During the study, participants complete MRI scans along with clinical assessments, including cognitive tests such as the MMSE. Researchers monitor brain function related to motor tasks using fMRI and collect clinical information to feed into artificial intelligence models. The main outcome measure is the accuracy of AI predictions for motor intention. Participants involvement spans from initial MRI data acquisition to detailed analysis, with results expected to support future clinical applications and provide a valuable resource for neuroscience research.