Guenrouet

Researchers are evaluating the effectiveness of inhaling a mixture of ginger and lemon essential oils to reduce nausea and vomiting caused by chemotherapy in patients with blood cancers. This study compares the essential oil blend to a placebo, alongside regular anti-nausea treatments, to see if it can improve symptoms during the early phase after chemotherapy. The trial takes place in five centers specializing in blood and cancer care and emphasizes a patient-focused approach to supportive care. Participants will receive aromasticks containing either the essential oil blend or a neutral oil to inhale. The study follows strict procedures for making and using the oils safely, coordinated by healthcare professionals trained in aromatherapy and research methods. This double-blind, randomized trial ensures that neither the participants nor the researchers know who receives the active treatment or placebo. During the study, participants' nausea levels will be tracked at one, two, and three months to assess the treatment's effectiveness. Researchers will also monitor quality of life and appetite. Patients must be able to use the aromasticks and communicate in French. Safety and adherence are carefully monitored throughout the trial.

Sepsis and its severe form, septic shock, pose significant health challenges involving organ failure and acute circulatory failure. Despite early treatment, many patients still experience worsening conditions and high mortality. This research aims to evaluate whether measuring small blood vessel function in emergency patients can improve outcomes by guiding early fluid treatment. The study compares the usual monitoring of circulation with additional assessments by nurses of peripheral perfusion index and skin mottling. If these measurements indicate poor microcirculation, a first fluid infusion of 500 mL over 30 minutes will be given after medical approval. Patients will be followed for seven days to assess their recovery and health status. Participants will be monitored closely during emergency care, with nurses measuring microcirculation parameters alongside standard tests. Researchers will track clinical deterioration within 24 hours after inclusion, using these data to see if early intervention based on microcirculation improves patient prognosis. The total follow-up period for each participant is seven days.