Guenrouet

Researchers are studying how inhaled aromatherapy using a mixture of ginger and lemon essential oils can help manage nausea and vomiting caused by chemotherapy in patients with blood cancers. This study aims to see if adding this aromatherapy to standard anti-nausea treatments improves nausea scores, quality of life, and appetite during the first day of chemotherapy treatment. The trial is conducted across multiple centers with experienced medical and nursing staff coordinating the safe and scientific use of aromatherapy. Participants are randomly assigned to one of two groups one receives the usual anti-nausea treatment plus inhalation of the ginger and lemon essential oil blend, while the other receives the same standard care plus a placebo aromastick with a neutral, odorless oil. Patients will use their assigned aromastick during three chemotherapy cycles. The study uses a double-blind design to compare the effects of the inhaled aromatherapy against placebo. During the study, participants will be monitored for nausea and vomiting intensity at various times up to three months after treatment begins. Researchers will also assess quality of life, dietary intake, and the use of antiemetic medications. The study includes evaluations at one day, four days, one month, two months, and three months to gather comprehensive data on symptoms and overall well-being. The total participation period covers multiple chemotherapy cycles and follow-up assessments to understand the impact of aromatherapy on chemotherapy-induced nausea and vomiting.

Sepsis and its severe form, septic shock, are serious health concerns characterized by organ failure and acute circulatory problems like low blood volume, blood vessel dilation, and heart dysfunction. Researchers are evaluating whether measuring microcirculation parameters such as the peripheral perfusion index and skin marbling by nurses can improve early treatment decisions and patient outcomes. This study focuses on the early detection of tissue blood flow problems that may not be obvious through standard measurements and aims to assess if early vascular filling based on these measures can reduce deterioration and mortality. Participants will be monitored using classic hemodynamic parameters plus additional measurements of peripheral perfusion index and marbling score. If the peripheral perfusion index is 3 seconds or more or marbling is present at a score of 1 or higher, nurses will initiate a vascular filling test by administering 500 cc of fluid over 30 minutes after confirmation by a senior doctor. All patients will continue to receive standard care treatments. This intervention period is closely linked to emergency department admission. Throughout the study, patients will be followed for 7 days to track clinical outcomes including deterioration within 24 hours after inclusion, organ function changes, mortality, lung fluid overload, and care setting decisions such as discharge or intensive care admission. The study also compares nurse and physician assessments of microcirculation. This detailed monitoring includes timing of treatment bundles and safety checks to evaluate how early microcirculation measurement impacts sepsis management and patient prognosis.