Saint Martin D Heres

Researchers are following 400 patients diagnosed with obstructive sleep apnea OSA across about ten sleep centers in France to study the long-term effects of two common treatments continuous positive airway pressure CPAP and mandibular advancement device MAD. The study focuses on how one year of treatment influences sleep quality and architecture, as well as patients reported quality of life. The research also aims to identify factors that predict improvements in sleep quality during treatment. Participants will use either a fixed-pressure CPAP device, which includes remote monitoring capabilities, or a custom-made MAD created from dental impressions by a specialist. Sleep will be monitored at home using a connected sleep test device over one year. This observational study collects routine clinical data to compare the impact of these treatments on sleep patterns. Throughout the study, participants will undergo sleep tests with the Sunrise device and complete assessments of their sleep quality and life quality. The main outcome measured is the change in deep slow-wave sleep after one year of treatment. Researchers will also collect clinical information to understand how these treatments affect sleep over time and monitor participants to ensure ongoing safety and study adherence.

Researchers are studying chronic pelvic pain in transgender people who are using testosterone therapy. This observational, qualitative study aims to describe the characteristics of this pelvic pain, how it affects quality of life, and to understand factors that help or hinder consulting healthcare professionals. The study is led by the University Hospital in Grenoble and focuses on transmasculine individuals experiencing new or changed pelvic pain since starting testosterone. Participants in this study will be transmasculine individuals using gender-affirming hormonal therapy who have had pelvic pain for at least six months that appeared or changed after starting testosterone therapy. The study involves a single semi-structured interview lasting about 1.5 hours. During this interview, participants will discuss their pelvic pain and its impact on their lives, and pelvic pain intensity will be assessed at the start. Participants will be recruited through community groups and mailings and will complete one interview. Researchers will analyze the interview data qualitatively to better understand the pain experiences and barriers to care. The main outcome measured is the detailed description of pelvic pain and its effect on quality of life. The study is planned to run until December 2025.

This clinical trial focuses on men with prostate cancer who are candidates for radical prostatectomy. It aims to compare outpatient versus inpatient robot-assisted radical prostatectomy to determine if managing the procedure as an outpatient leads to similar rates of early post-operative complications. The study evaluates early recovery outcomes and overall patient experience after surgery. Participants will undergo robot-assisted radical prostatectomy either as outpatients or inpatients. The trial compares these two approaches by monitoring early complications from the day of surgery up to eight days afterward. Additional outcomes evaluated include surgery duration, blood loss, recovery of urinary and erectile function, stress and anxiety levels around surgery, patient satisfaction, and longer-term follow-up for up to five years. During the study, participants will visit the clinic at 45 days, 6 months, and annually up to 5 years for check-ups and tests. They will complete surveys on urinary and erectile function, stress, anxiety, satisfaction, and quality of life for six months. Participants are also asked to keep diaries recording treatments and care procedures. Researchers will track hospital readmissions, complications, and economic and social costs related to patient care throughout the follow-up period.

Researchers are investigating kidney cancer through the UroCCR network, a national registry and research platform in France that collects detailed real-world data on patient care and disease progression. Established in 2011, this extensive database includes over 21,000 cases from 58 centers and links clinical information with annotated biological samples and national health data. The platform supports multiple types of research, including translational studies, clinical evaluations, and social science investigations, aiming to improve understanding and management of renal cell carcinoma. The study involves adult patients diagnosed with kidney cancer and documents their treatments, including procedures such as radical or partial nephrectomy as determined by the surgeon. Data collected encompasses clinical parameters, imaging, patient-reported outcomes, and socioeconomic factors. The registry supports prospective research projects and ancillary studies, with a focus on real-world practice following national guidelines. It also integrates digital tools for monitoring and prediction, enhancing personalized treatment strategies. Participants contribute data continuously from enrollment through long-term follow-up, which may last until death or withdrawal. The study collects comprehensive clinical, biological, imaging, and patient-reported information, along with biological samples like plasma, urine, and tumor tissue. Researchers measure outcomes related to research project promotion, biological sample collection, epidemiology, treatment monitoring, quality of life, biomarker research, and clinical practice evaluation. This ongoing data collection supports knowledge advancement and improved kidney cancer care over many years.