Saint Martin D Heres

The REMAP study is designed to follow 400 patients with obstructive sleep apnea (OSA) in about ten sleep centers across France. It aims to evaluate the effects of one-year treatment using continuous positive airway pressure (CPAP) or a mandibular advancement device (MAD) on sleep quality. The study focuses on changes in sleep architecture measured by objective sleep parameters from a home-connected sleep test device, and also assesses patient-reported sleep quality and quality of life. Additionally, the study seeks to identify factors that predict improved sleep quality during OSA treatment. Participants receive treatment with either a fixed-pressure CPAP device, which includes optional humidification, a heated circuit, and remote monitoring capabilities, or a custom-made MAD created from dental impressions by a specialist. Both treatment options are used to manage OSA symptoms, and the study compares their long-term impact on sleep over the course of one year. During the study, participants undergo sleep tests using the Sunrise device to monitor sleep patterns. Researchers collect clinical routine data, including sleep architecture details and patient questionnaires on sleep quality and quality of life. The primary outcome is the change in deep slow-wave sleep after one year of treatment. The study also monitors safety and treatment adherence, with the total duration of participation lasting 12 months.

Researchers are exploring the characteristics of new chronic pelvic pain in transgender individuals who use testosterone therapy, focusing on its effects on their quality of life. The study also aims to identify challenges and supports related to seeking healthcare for this condition. This observational, single-center qualitative study targets transmasculine people experiencing pelvic pain that started or changed after beginning testosterone treatment. The study will include 10 to 15 transgender participants who have been on gender-affirming hormonal therapy and have experienced pelvic pain for at least six months. These individuals will participate in semi-structured interviews lasting around 1.5 hours to share their experiences. Recruitment will occur through community care groups, mailing lists, and flyers. Data from the interviews will be analyzed qualitatively using QCAMAPS for coding. Participants will be involved in detailed interviews to describe their pelvic pain and its impact on their daily lives. The research team will assess the pain and quality of life through these conversations. The study aims to provide a clear understanding of the symptoms and the barriers and facilitators to receiving appropriate care. The total length of participation includes the interview and any related assessments for the qualitative analysis process.

Researchers are investigating whether managing robot-assisted radical prostatectomy as an outpatient procedure is as safe as doing it as an inpatient procedure by comparing early post-operative complications. The study focuses on men with prostate cancer who have been recommended for this surgery and aims to confirm that outpatient care is not inferior to inpatient care in terms of complications occurring within the first 8 days after surgery. The intervention involves robot-assisted radical prostatectomy performed either as outpatient or inpatient care. Participants will undergo the surgical procedure and then follow the assigned care method. The study evaluates early complications occurring from the day of surgery up to 8 days afterward to determine safety and effectiveness between the two groups. Participants will visit the clinic once after the operation at 45 days, 6 months, and then yearly for up to 5 years for ongoing check-ups and tests. During the first 6 months, they will complete surveys on urinary and erectile functions, stress, anxiety, satisfaction, and quality of life. Additionally, participants will keep a diary to record procedures and treatments related to their care. These measures help researchers assess recovery, well-being, and long-term outcomes while monitoring safety throughout the study period.

Rotator cuff injuries cause shoulder pain and weakness that may need surgery, typically done under general anesthesia combined with loco-regional anesthesia (LRA) to numb the shoulder. This research compares blood pressure during surgery for rotator cuff repair using LRA alone versus LRA with general anesthesia. The study highlights that LRA alone may maintain blood pressure better and allow the patient to stay conscious, enabling real-time clinical assessment during surgery. The surgery involves arthroscopic rotator cuff repair, often including acromioplasty and sometimes tenotomy of the long biceps tendon. Two anesthesia methods are compared: LRA alone, where anesthetic is injected near the brachial plexus using ultrasound guidance, and LRA combined with general anesthesia, which adds intravenous drugs and anesthetic vapors. Both approaches use anesthetics like naropeine or chirocaine. The study is a randomized controlled trial designed to assess the superiority of one method over the other. Participants will have their blood pressure measured during surgery as the primary outcome. Researchers will monitor the patients continuously to compare systolic blood pressure on the day of surgery. The study includes adult patients requiring rotator cuff repair with specific tendon and muscle conditions. Participants must give informed consent and meet eligibility criteria to ensure safety and compliance throughout the study.

Researchers are investigating kidney cancer through the UroCCR project, a national registry and research network in France dedicated to renal cell carcinoma (RCC). This platform collects detailed clinical, imaging, biological, and patient-reported data on kidney cancer from over 21,000 cases across 58 centers. The study aims to improve understanding of RCC management by integrating multidisciplinary care data, biological samples, and linking with national health datasets to support translational research, clinical evaluation, and social science studies. The study compares two surgical treatments for kidney cancer: radical nephrectomy and partial nephrectomy, with the choice of surgery made according to surgeon judgment. It follows patients over long periods, monitoring outcomes and complications after surgery. This national collaboration includes digital tools like perioperative monitoring and machine learning models to predict recurrence and survival. The network also supports ancillary studies, including retrospective and prospective clinical trials, to advance personalized treatment strategies. Participants provide comprehensive data on their clinical status, treatments, and quality of life. Researchers assess complications at multiple time points: 3, 6, and 12 months post-surgery, then yearly for 5 years, and every 2 years for up to 10 years. The study evaluates real-world outcomes in kidney cancer care, linking clinical information with biological samples and national health data, while ensuring standardized procedures, ethical oversight, and high data quality through robust governance.