Trelaze

This research aims to find out how common cardiac amyloidosis is in older adults aged 80 years and above who have been hospitalized for heart failure and have thickening of the heart muscle (left ventricular hypertrophy). Patients will be recruited from 31 geriatric or cardiology centers over 24 months. Each participant will have a baseline visit where medical history, clinical data, frailty status, genetic testing, and heart ultrasound data will be collected. Bone scans using 99mTc-DPD or 99mTc-HMDP will be done during or after hospitalization to check for amyloidosis in the heart muscle. After the initial visit, participants will receive follow-up phone calls every 3 months for 12 months to track hospitalizations, nursing home admissions, and death. The main measure is the number of patients diagnosed with cardiac amyloidosis based on bone scintigraphy at the start of the study.

Low back pain is a common condition affecting about 23% of the general population and can lead to challenges such as psychosocial difficulties and prolonged inability to work. In France, treatment usually involves general practitioners and sometimes physiotherapists. Researchers are evaluating whether coordinated care involving general practitioners, physiotherapists, and occupational health services can improve the management and outcomes for patients with subacute or recurrent acute low back pain compared to standard care. The study compares two approaches: coordinated care and standard care. Coordinated care includes early contact with occupational health services initiated by the general practitioner and the use of an occupational retention tool. Patients in this group also receive an active physiotherapy program consisting of 15 individual, intensive, and regular rehabilitation sessions lasting one hour each, scheduled two to three times per week. This approach is deployed at the territory level to assess its impact on patient outcomes. Participants will be followed for one year after enrollment. During this time, researchers will monitor the perceived inability to work as the primary outcome. The study involves regular assessments and tracking of patient progress to evaluate the effectiveness of coordinated care in reducing prolonged disability related to low back pain. Overall, the study aims to improve the care pathway and reduce the risk of long-term disability for patients in primary care settings.

Recent research has observed a rise in the age at which puberty begins, both in the United States and Europe, with a noted increase in cases of precocious puberty that varies by region. Early puberty can lead to early menstruation, shorter adult height, and psychological effects. Due to limited studies and data, the reasons behind these trends remain unclear, though environmental factors such as endocrine disruptors and nutrition are considered possible contributors. This study aims to create a national observatory to monitor early and advanced puberty in collaboration with pediatric endocrinologists to improve epidemiological understanding. The observatory will focus on identifying cases of precocious and advanced puberty in private healthcare settings. It will include groups with suspected early puberty (girls under 8 years, boys under 9 years) and advanced puberty (girls aged 8 to under 10 years, boys aged 9 to under 11 years) based on the appearance of first pubertal signs. A control group of children without signs of puberty, matched by age and sex, will also be included. The study intends to enroll at least 75% of eligible patients and collect at least 80% of the main data. Participants will have consultations with pediatric endocrinologists who will collect clinical data over a period of up to 48 months. The study will monitor data completeness and recruitment rates, aiming to maintain high-quality data collection throughout the observation period. The observatory seeks to provide a reliable, detailed field approach to supplement existing epidemiological information on pubertal development.