Papeete

Researchers are investigating the occurrence of idiopathic bronchi dilation among Polynesian patients, focusing on cases in French Polynesia and exploring possible genetic factors. This observational study aims to better understand the detailed characteristics of bronchi dilation in this population and to find indirect evidence supporting a genetic cause. The study will collect retrospective data from patients with bronchial dilation who were followed at the Centre Hospitalier de Polynesie Francaise between January 1, 2010, and December 31, 2020, or who no longer consult at the hospital during this period. Information gathered will include patients personal and family medical history, microbiological results, scan images, and recent cardio-respiratory evaluations. Participants data will be reviewed to describe their bronchi dilation phenotype and to investigate the genetic links to the condition. The research team will analyze historical medical records and test results without active intervention. The main outcome measured is a detailed description of the bronchi dilation features in the Polynesian population, with secondary outcomes focusing on evidence suggesting a genetic cause. The study is expected to complete by June 2027.

Researchers are investigating the genetic and molecular factors involved in gout, inflammation, and metabolic diseases in French Polynesia. This study aims to better understand the high rates of gout and hyperuricaemia in the adult population, as well as related conditions like obesity and type 2 diabetes. The goal is to identify genetic contributors and track the long-term effects of hyperuricaemia and associated health risks. Participants are grouped into the general population, gout patients, and a follow-up group from a previous 2021 study called TOPATA. The study involves collecting sociodemographic data, clinical exams, questionnaires, and blood and urine samples for genetic and biochemical analyses. Some gout patients with recent attacks will provide additional samples one week later to monitor acute flare changes. During the study, participants will undergo various assessments including physical exams, laboratory tests, and questionnaires about health, diet, and lifestyle. Researchers will measure genetic associations, correlations between gout and metabolic conditions, disease progression, and cardiovascular events. The study spans several years, with key outcomes assessed at 12 months and up to 4 years, to better understand disease mechanisms and support future therapies.