Kabupaten Sleman

This trial studies children aged 0 to 18 years with blood cancers who have a high risk of fever due to low white blood cell counts. It aims to compare two antibiotics, ciprofloxacin and ceftazidime, to see which works better as the first treatment for high-risk fever in these children. The study also looks at factors that may affect how children respond to these treatments and compares outcomes like fever length, neutropenia duration, hospitalization time, and mortality. Participants are randomly assigned to receive either intravenous ciprofloxacin at 10 mg/kg every 12 hours or intravenous ceftazidime at 150 mg/kg per day divided into three doses. This treatment is given during hospitalization, which occurs between June and December 2025 at Sardjito General Hospital. The study follows a controlled, randomized design to evaluate the effectiveness of these antibiotics in treating high-risk neutropenic fever. During the study, researchers collect medical history, perform physical exams, and run supporting tests. They monitor each child’s fever duration, neutropenia length, hospital stay, antibiotic use, any changes in antibiotics, and mortality. The study tracks these outcomes from the start of antibiotic treatment until 48 hours after fever resolution or neutropenia ends. This phase 4 trial helps understand the best antibiotic choice and management for children with hematological malignancies experiencing high-risk fever.

Researchers are evaluating whether a home-based cardiac rehabilitation program with a family empowerment approach can help patients recovering from acute coronary syndrome (ACS). This study focuses on improving health-related quality of life and peak oxygen consumption (peak Vo2) compared to usual care. The trial includes adults aged 18 to 65 years who have experienced their first acute coronary event, with or without undergoing PCI, and who live with family members involved in their care. The intervention lasts 12 weeks and involves home-based cardiac rehabilitation that includes physical exercise, dietary management, smoking cessation, and stress management. Patients and their families receive educational materials, videos from health professionals, and guidance from facilitators to empower family involvement. Exercise sessions are done three times a week with family monitoring heart rate and symptoms. Follow-ups with cardiologists occur at weeks 1, 6, and 12, with nurse facilitators providing monitoring via video calls or home visits. Participants will perform walking exercises, follow diet and stress recommendations, quit smoking, and adhere to medications. They will visit clinics for cardiologist assessments and undergo a 6-minute walk test to measure peak Vo2. Families report daily on diet, exercise frequency, medication adherence, and exercise-related heart rate and symptoms through online forms. Researchers measure health-related quality of life and peak Vo2 from enrollment through the 12-week treatment period, with safety and progress closely monitored throughout.

Researchers are evaluating a brief culturally adapted behavioral activation intervention to help adults with depression in a primary care setting. This pilot study aims to determine whether this individual intervention, delivered by a primary care psychologist, is acceptable, feasible, and appropriate for reducing depressive symptoms. The study uses a mixed method and single arm design to understand how well this intervention fits the cultural context and clinical setting before a larger trial. Participants will receive three face-to-face individual sessions of the brief culturally adapted behavioral activation intervention, each lasting 30 to 45 minutes. During these sessions, they will learn behavioral techniques to reduce depression and improve well-being, with homework activities to practice these skills in daily life. Both participants and psychologists will complete standardized questionnaires before and after the intervention, and semi-structured interviews will be conducted to gather detailed feedback about their experiences. During the study, researchers will assess participants' depressive symptom levels and quality of life before and after the intervention. They will also measure how acceptable, feasible, and appropriate the intervention is using specific questionnaires and interviews completed within one week after the intervention ends. This information will help refine the intervention for future effectiveness and implementation trials.