Kabupaten Sleman

Researchers are evaluating a brief culturally adapted behavioral activation therapy for adults with depression in Indonesian primary care settings. This study has two main goals to see if this therapy, delivered by primary care psychologists in face-to-face sessions, effectively reduces depressive symptoms, and to assess how training and supervision of psychologists affect the therapys acceptability, feasibility, appropriateness, and delivery quality. The study addresses the challenge of treating depression in lower-income countries and aims to improve mental health care integration into primary care. The study randomly assigns twelve primary health centers into two groups. Six centers form the intervention group where selected psychologists receive online training and ongoing supervision to deliver three face-to-face therapy sessions to adult patients. The other six centers provide usual depression treatment without specific training or restrictions on therapy type or session number. Training includes four online sessions, two booster sessions, and supervision through biweekly online meetings and continuous support. Participants will be adults aged 18 to 65 years with depression, screened by the PHQ-9 questionnaire. The study measures changes in depressive symptoms using the PHQ-9 one week after therapy, and gathers feedback on therapy acceptability and feasibility from both patients and providers. Additional assessments include remission rates, anxiety levels, behavioral activation, and quality of life up to one month post-intervention. The study involves interviews and questionnaires over approximately three months to evaluate both clinical and implementation outcomes.

This research aims to compare the use of ciprofloxacin and ceftazidime in treating high-risk fever caused by low neutrophil count in children with hematological malignancies. It focuses on children aged 0 to 18 years diagnosed with blood cancers such as acute lymphoblastic leukemia, acute myeloblastic leukemia, and non-Hodgkin lymphoma. The study evaluates which antibiotic works better as a first-choice treatment and investigates factors influencing response to these drugs. Participants will be randomly assigned to receive either intravenous ciprofloxacin at 10 mgkg every 12 hours or intravenous ceftazidime at 150 mgkg per day divided into three doses. The treatments are given during hospitalization between June and December 2025. Both groups will be monitored for outcomes like the length of fever, duration of low white blood cell count, hospital stay length, antibiotic use duration, any changes in antibiotic treatment, and death rates. Throughout the trial, participants will undergo medical history collection, physical exams, and supportive tests. Researchers will track key measures including duration of fever and neutropenia from the start of antibiotic treatment, hospitalization duration, and antibiotic escalation decisions. Safety and mortality will also be assessed up to 30 days after enrollment. This comprehensive monitoring aims to understand the effectiveness and clinical impact of these antibiotics in managing high-risk neutropenic fever in children with blood cancers.

Researchers are evaluating whether home-based cardiac rehabilitation combined with a family empowerment approach can help patients recovering from acute coronary syndrome ACS. The study aims to find out if this method improves health-related quality of life and peak oxygen consumption peak Vo2 better than usual care. The trial includes adult patients aged 18 to 65 who have recently experienced ACS and have been discharged from the hospital between 3 months and 1 year prior to enrollment. Participants in the experimental group will undergo a 12-week home-based cardiac rehabilitation program that includes physical exercise, dietary management, smoking cessation, and stress management guided by educational materials and support from family and healthcare professionals. The intervention also involves regular monitoring of vital signs and exercise intensity based on a 6-minute walk test. The control group will receive usual care with education on medication adherence, exercise, smoking behavior, diet, and stress management in a single session. During the study, participants will perform prescribed walking exercises, follow diet and stress management plans, quit smoking, and comply with medication. They will visit a cardiologist at weeks 1, 6, and 12, and receive ongoing support from a nurse facilitator through video calls or home visits. Researchers will assess health-related quality of life and peak Vo2 at enrollment and after 12 weeks. Daily reports on diet, exercise, medication adherence, and heart rate during exercise will be collected and monitored to evaluate progress and safety.