Kota Denpasar

Researchers are studying healthy infants in Indonesia to compare the immune response and safety of two vaccines Minhais 13-valent Pneumococcal Polysaccharide Conjugate Vaccine PCV13-DTTT, also called Pneuminvac and Pfizers 13-valent Pneumococcal Conjugate Vaccine PCV13, known as Prevenar 13. The study focuses on infants aged 6 to 8 weeks and aims to show that Pneuminvac produces immune responses that are not worse than Prevenar 13 after a booster dose, while also monitoring vaccine safety when given together with a hexavalent vaccine. About 500 infants will be randomly assigned to two groups one receiving Pneuminvac and the other receiving Prevenar 13. Both vaccines will be given at 2, 4, and 12 to 15 months of age. Additionally, all infants will receive the hexavalent vaccine at 2, 3, and 4 months of age. This design follows World Health Organization recommendations for infant vaccination schedules. Participants will attend scheduled visits for vaccinations and assessments, including blood tests to measure immune responses one month after the booster dose. Safety will be closely tracked by recording any side effects after each vaccine dose and serious adverse events up to six months after the booster. The study aims to evaluate the percentage of infants with protective antibody levels and compare immune responses between vaccines, with total participation lasting from enrollment until several months after the final vaccine dose.

Researchers are evaluating the effects of different exercise training methods on muscle structure and the prevention of Patellofemoral Pain Syndrome and Anterior Cruciate Ligament ACL injuries in sportsmen aged 15 to 35 who participate in level 1 sports such as martial arts, basketball, futsal, and soccer. This clinical trial compares low-load blood flow restriction training LL-BFRt, a sham version of LL-BFRt, and high-load eccentric training HL-Et to see which method better improves muscle morphology and reduces injury risk. Participants will be randomly assigned to one of three groups LL-BFRt, sham LL-BFRt, or HL-Et. The LL-BFRt group will perform eccentric exercises like stairs, single leg squats, and single leg deadlifts at 30% of their maximum repetition and with 70% arterial occlusion pressure applied by cuffs. The sham LL-BFRt group will do the same exercises at 30% maximum repetition but with only 10% arterial occlusion pressure. The HL-Et group will perform the exercises at 70% maximum repetition without blood flow restriction. Both treatments are guided by a physical therapist. Throughout the study, researchers will measure muscle cross-sectional area, fiber angle of the vastus medial obliques, and patella position after 8 weeks. They will also monitor the incidence of Patellofemoral Pain Syndrome and ACL injuries over one year. Participants are expected to maintain their assigned exercise regimen and provide informed consent. The study aims to understand which training method offers better muscle improvements and injury prevention in active sports participants.

This research aims to evaluate the effectiveness of dry needling and Low-Level Laser Microcurrent Electrical Stimulation LL MCES in adults aged 20 to 45 years with acute upper trapezius myofascial pain syndrome MPS. The study focuses on understanding if these treatments reduce inflammation and oxidative stress by measuring changes in serum tumor necrosis factor-alpha TNF- and malondialdehyde MDA levels, alongside improvements in pain and neck-related disability. This trial addresses the gap in knowledge about how these biological changes relate to clinical benefits from non-drug therapies. Participants are randomly assigned to one of four groups dry needling alone, LL MCES alone, combined dry needling and LL MCES, or sham dry needling that mimics treatment without actual needle penetration. Treatments target the upper trapezius muscles trigger points using standardized protocols. Blood samples are collected before and after the intervention to assess serum TNF- and MDA levels. Clinical assessments of pain intensity and neck disability are also completed before and after treatment. During the study, participants attend scheduled follow-up visits for clinical evaluation and outcome measurement. Researchers use the Numerical Pain Rating Scale NPRS and Neck Disability Index NDI to gauge pain and function. Safety and adherence are monitored throughout. The primary outcomes include changes in serum MDA and TNF- concentrations measured at baseline and three days after treatment completion. The total participation period extends from treatment through follow-up assessments.

Emergence agitation is a common complication in children after general anesthesia, especially when sevoflurane is used. This condition involves restlessness, confusion, and distress during recovery and can cause self-injury and increased caregiver stress. Researchers are evaluating whether giving a lollipop after surgery can reduce the incidence and severity of this agitation in pediatric patients aged 2 to 6 years undergoing sevoflurane anesthesia. In this randomized controlled trial, children will be randomly assigned to either receive a lollipop immediately after awakening from anesthesia or receive standard postoperative care without a lollipop. The intervention aims to offer a simple, non-drug approach to improve recovery. The study will compare the two groups by assessing agitation levels using a validated scale during the first hour after anesthesia emergence. Participants will be monitored in the recovery room where their emergence agitation will be measured using the PAED scale from 0 to 60 minutes after waking up. Researchers will also observe recovery time, the need for additional medication, and any adverse events. The study is designed to provide evidence on a safe, practical, and cost-effective method to enhance postoperative recovery for young children.

Carpal Tunnel Syndrome CTS is caused by pressure on the median nerve in the wrist, leading to pain, numbness, tingling, and reduced hand function. This trial examines how adding amniotic membrane combined with secretome to standard carpal tunnel release surgery affects symptom relief and nerve recovery in adults with moderate-to-severe CTS. The study is a randomized controlled trial comparing surgery alone to surgery plus these biological treatments, using clinical and nerve tests to evaluate results. Participants will be randomly assigned to one of three groups standard carpal tunnel release surgery, surgery with amniotic membrane applied to the median nerve, or surgery with amniotic membrane soaked in secretome solution applied to the nerve. The amniotic membrane used measures 10 mm by 10 mm and is applied during surgery. Secretome is soaked onto the membrane for one minute before placement. The study focuses on treatments delivered during the surgical procedure. Participants will be assessed before surgery and again three weeks after the procedure. Evaluations include the Boston Carpal Tunnel Questionnaire BCTQ to measure symptoms and hand function, and electromyography EMG to assess nerve regeneration. The study is double-blinded and sponsored by PT. Prodia Stem Cell Indonesia. Participants are expected to comply with study procedures and provide informed consent, with total follow-up lasting at least three weeks post-surgery.

This research aims to evaluate the benefits of using a Peripheral Nerve Block called the Modified Thoracoabdominal Perichondrial Approach M-TAPA compared to standard intravenous opioids in patients undergoing laparoscopic cholecystectomy. The goal is to see if M-TAPA can reduce pain and the need for opioid medication after surgery. The study involves adult patients aged 18 to 65 years with specific health criteria. Participants will be randomly assigned to one of two groups. One group P1 receives the M-TAPA nerve block administered by an anesthesiologist using ultrasound guidance during surgery along with general anesthesia. The other group P2 receives only intravenous opioids after surgery without the nerve block. Both groups undergo the same laparoscopic cholecystectomy procedure. The nerve block involves injections on both sides of the upper abdomen with the local anesthetic bupivacaine. Patients are closely monitored for side effects during and after the procedure. During the study, participants will be assessed before surgery, during anesthesia, and up to 24 hours after surgery. Pain levels are measured using a Numeric Rating Scale at multiple time points, and opioid use is tracked via a PCA infusion device. Recovery quality is also evaluated with a questionnaire before surgery and 24 hours afterward. Vital signs and side effects are monitored continuously in the recovery room. The study focuses on measuring pain relief effectiveness and opioid consumption within the first 24 hours post-operation.

Researchers are comparing two injection treatments, secretome and intradermal platelet-rich plasma PRP, to see how they affect hair density and the ratio of terminal to vellus hairs in people with androgenetic alopecia. This randomized controlled clinical study takes place at Prof. Dr. I.G.N.G. Ngoerah General Hospital and focuses on adults aged 25 to 59 years with specific stages of hair loss. The purpose is to evaluate which treatment better supports hair growth and density. Participants receive either umbilical cord mesenchymal stem cell-derived secretome or platelet-rich plasma injections. Both treatments involve intradermal injections spaced 1 cm apart at the alopecia site and are administered every 2 weeks for a total of 8 weeks. The secretome and PRP injections are given under controlled conditions, with patients randomly assigned to one of the two groups. During the study, hair density and the terminal-to-vellus hair ratio are measured before treatment, at 8 weeks after intervention, and again during follow-up visits at months 3, 6, and 9. Evaluations use trichoscopy or dermoscopy to monitor changes. Participants provide informed consent and are monitored throughout the study to track treatment effects and safety. The total study duration includes treatment and follow-up periods to assess long-term outcomes.