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Found 4 Actively Recruiting clinical trials
Actively Recruiting
Researchers are studying the effect of chest physiotherapy education on mothers knowledge, practice, and the clinical outcomes of infants diagnosed with bronchiolitis who are under 12 months old. The study aims to find out if chest physiotherapy improves infants health and whether the educational program enhances mothers understanding and application of the therapy. It is a randomized clinical trial comparing two groups over a period of 3 days. One group receives routine hospital care, while the other group receives the same routine care plus chest physiotherapy performed by the mothers after being educated on the technique. Chest physiotherapy in this study involves classical techniques applied by the mothers to their infants. The study evaluates these interventions over a short-term follow-up period of 3 days to observe any differences. Participants will be monitored for changes in clinical and physiological outcomes related to bronchiolitis from baseline. Researchers will also assess improvements in mothers knowledge and practices regarding chest physiotherapy after three days. The study includes regular follow-ups and observations during the 3-day period to track these outcomes. The total participation duration aligns with this brief follow-up timeframe.
Actively Recruiting
Healthy Volunteer
This research aims to study the use of 3D-printed shape memory aligners for treating adults with anterior dental open bite. It compares three groups patients using conventional clear aligners with attachments, those using 3D direct-printed shape memory aligners without attachments, and those using 3D direct-printed shape memory aligners with attachments. The study explores their effects on molar intrusion, anterior teeth extrusion, stress distribution, and initial tooth displacement. Participants will wear clear aligners for about 6 to 8 months depending on their assigned group. The aligners include conventional thermoformed and direct 3D-printed shape memory types, some with rectangular attachments bonded to teeth. The treatment includes digital scanning, custom aligner design, and aligner insertion with instructions to wear them at least 22 hours per day. Initial measurements and imaging like CBCT and intraoral scans are taken before and after the first series of 15-20 aligners. Throughout the study, participants undergo assessments including cephalometric analysis, CBCT imaging, and patient-reported outcome measures PROMs on pain, mobility, strength, and satisfaction before and after treatment. Compliance is self-recorded and monitored. The study will evaluate dental and skeletal changes, molar intrusion, and tooth movement using advanced imaging software and finite element analysis. Participation lasts about 8 to 14 months, with data collected at baseline and after the first aligner series.
Actively Recruiting
Healthy Volunteer
Researchers are evaluating the effectiveness and safety of High-Intensity Laser Therapy HILT compared to conventional physical therapy in adults with knee osteoarthritis, a condition causing pain, stiffness, and reduced mobility. This trial aims to see if HILT combined with exercises offers better pain relief and joint function improvement than standard physical therapy combined with the same exercises. The study will recruit 100 patients diagnosed with knee osteoarthritis based on recognized criteria. Participants will be randomly divided into two groups. One group will receive HILT using a four-wavelength laser system with specific frequencies and modes designed for deep tissue penetration, along with a standardized exercise program. The other group will receive standard physical therapy modalities such as therapeutic ultrasound or TENS combined with the same exercise program. Treatments will be conducted at specialized rheumatology and rehabilitation centers, with outcomes assessed at multiple time points. During the study, participants will undergo evaluations of pain levels using scales like WOMAC and VAS, joint function assessments, and MRI scans to observe structural changes in the knee. Laboratory tests will measure inflammation markers, cartilage metabolism genes, and oxidative stress before and after treatment. The main outcome focuses on pain intensity changes after four weeks, with additional assessments at eight weeks. The total participation period and follow-up details are included to monitor safety and effectiveness.
Actively Recruiting
Healthy Volunteer
This research aims to evaluate two different doses of Bemiparin, a low-molecular-weight heparin, for preventing venous thromboembolism VTE in morbidly obese patients undergoing non-orthopedic surgery. Morbid obesity is linked to a high risk of VTE, especially after surgery, and fixed doses of anticoagulants may not provide optimal protection. The study seeks to find effective and safe thromboprophylaxis strategies tailored to this high-risk group. Participants will receive one of two Bemiparin doses 3,500 IU or 5,000 IU, administered by injection under the skin 6 hours after surgery. Treatment continues daily for up to 10 days for moderate and high-risk patients, and up to 30 days for very high-risk patients, based on the Caprini risk classification for VTE. The study excludes orthopedic surgery patients to focus on non-orthopedic surgical cases. During the study, participants will be monitored for VTE events such as deep vein thrombosis or pulmonary embolism up to 30 days after surgery. Researchers will also assess side effects from both dosing regimens. Participants will undergo regular follow-up visits and evaluations to track outcomes and ensure safety throughout the study period.