Pietra Ligure

Researchers are conducting an observational, prospective, multicenter study in Italian cardiology centers to evaluate how well patients with Heart Failure with Reduced Ejection Fraction (HFrEF) follow guideline-recommended treatments. The study also aims to assess the safety of these treatments, monitor treatment patterns in patients with acute heart failure, and observe treatment approaches in all chronic heart failure patients regardless of their ejection fraction levels. The study involves two phases of educational interventions and data collection. Initially, healthcare providers will receive education on guideline recommendations and treatment patterns, followed by 3 months of patient data collection or up to 30 consecutive patients with chronic or acute heart failure. After 6 months, treatment modifications and outcomes will be evaluated. Then, a second educational session will highlight gaps between guidelines and practice, followed by another 3 months of data collection. Patients will be followed for 12 months total, with ongoing monitoring of treatment changes and outcomes. Participants will be assessed at enrollment and during the follow-up periods through clinical evaluations and data collection on treatment adherence and safety. The main outcome measured is adherence to guideline-directed medical therapies over 6 months. The study includes evaluations at 6 and 12 months after enrollment, with close monitoring of treatment patterns and patient health status throughout the study duration.

Researchers are evaluating patients who have experienced athero-thrombotic events such as coronary artery disease, cerebrovascular disease, or peripheral artery disease. The study aims to assess how well patients follow guideline recommendations, particularly focusing on improving cholesterol levels and other modifiable risk factors to reduce the chance of cardiovascular event recurrence. This observational and prospective study takes place across multiple cardiology centers in Italy to represent a broad patient population. The study includes several phases starting with an educational intervention to discuss guideline recommendations for secondary prevention. Following this, data is collected for three months or until 30 patients with documented cardiovascular conditions are enrolled, using a web-based case record form that identifies when guidelines are not followed and records reasons for non-adherence. After six months, primary and secondary outcomes are evaluated. A second educational intervention then shares findings from the first phase to highlight gaps in clinical practice, followed by another three-month data collection period and a further six-month outcome assessment. Finally, all patients are followed for 12 months to monitor longer-term results. Participants provide informed consent and are monitored through data collection forms that track adherence to guidelines and clinical outcomes. The main outcome measured is adherence to cholesterol management guidelines over six months. Additional assessments include adherence to recommendations for other cardiovascular risk factors. Throughout the study, researchers gather data to understand how guideline adherence affects patient health and to identify barriers to following best practices, with continuous follow-up over a year to evaluate sustained effects.

Researchers are studying patients who have suffered acute strokes caused by large vessel blockages. The focus is on comparing different emergency antithrombotic treatments for patients who need rescue stenting after mechanical thrombectomy fails to fully reopen the blocked vessel. This study aims to better understand the safety and effectiveness of these treatments, especially in patients who receive intravenous thrombolysis before stenting. The study involves patients undergoing mechanical thrombectomy and rescue stenting within 24 hours of stroke onset. Researchers observe how various antithrombotic strategies are used in real-world emergency stenting cases, particularly when combined with intravenous thrombolysis. The study monitors treatments administered and the timing of antiplatelet therapy after stenting. During the study, participants undergo clinical evaluations to assess outcomes and safety, including monitoring for symptomatic cerebral hemorrhage within 24 hours. Researchers track recovery and complications to evaluate the best approaches for antithrombotic therapy after rescue stenting. The total participation time depends on clinical follow-up after the acute treatment phase.

Chronic pain, including nociceptive and neuropathic types, greatly affects psychological health and quality of life but remains difficult to manage due to its complex physical and emotional nature. This research investigates how advanced Artificial Intelligence and wearable sensors can better understand and monitor the multiple dimensions of pain. The study seeks to improve personalized pain treatment by capturing detailed physiological and psychosocial data outside of hospital or lab settings. Participants will be observed without any experimental treatment through a telemonitoring system that includes robotic wearable sensors measuring skin conductance, blood volume pressure, heart rate, and activity. They will also use a digital platform to report psychological assessments, medication use, pain levels, and sleep quality. AI models will analyze this combined data to characterize the nature of each participant's pain. During the study, participants will be monitored continuously during daily and nightly activities. Researchers will collect data on pain levels, psychosocial and physiological pain components, medication usage, and psychological and clinical factors affecting pain. The study aims to gather up to one month of detailed information, helping to identify biomarkers and improve pain management strategies.