Sanremo

Researchers are evaluating patients who have experienced athero-thrombotic events such as coronary artery disease, cerebrovascular disease, or peripheral artery disease. The study aims to assess how well patients follow guideline recommendations, particularly focusing on improving cholesterol levels and other modifiable risk factors to reduce the chance of cardiovascular event recurrence. This observational and prospective study takes place across multiple cardiology centers in Italy to represent a broad patient population. The study includes several phases starting with an educational intervention to discuss guideline recommendations for secondary prevention. Following this, data is collected for three months or until 30 patients with documented cardiovascular conditions are enrolled, using a web-based case record form that identifies when guidelines are not followed and records reasons for non-adherence. After six months, primary and secondary outcomes are evaluated. A second educational intervention then shares findings from the first phase to highlight gaps in clinical practice, followed by another three-month data collection period and a further six-month outcome assessment. Finally, all patients are followed for 12 months to monitor longer-term results. Participants provide informed consent and are monitored through data collection forms that track adherence to guidelines and clinical outcomes. The main outcome measured is adherence to cholesterol management guidelines over six months. Additional assessments include adherence to recommendations for other cardiovascular risk factors. Throughout the study, researchers gather data to understand how guideline adherence affects patient health and to identify barriers to following best practices, with continuous follow-up over a year to evaluate sustained effects.

Older adults face a high risk of serious respiratory infections like influenza, SARS-CoV-2, respiratory syncytial virus, and human metapneumovirus, which often cause hospitalization, death, and loss of independence. This international study focuses on people aged 60 years and older who are hospitalized with these infections to better understand how these illnesses affect their ability to perform daily activities and recover function. The goal is to provide evidence that can guide vaccination and prevention efforts to support healthier aging. Participants are hospital patients confirmed by PCR test to have one of the listed respiratory viruses, including those with co-infections. The study observes their functional dependency over time using daily living activity scores. There are no interventions or treatments tested in this study; it is observational and collects data at hospital admission and during follow-up. During the study, researchers assess participants' abilities to perform daily and instrumental activities at baseline, hospital discharge, 7 days, 3 months, and 6 months after discharge. These evaluations help measure how infection impacts independence and recovery. Follow-up phone calls at 3 and 6 months are conducted to monitor progress. The study also tracks safety and adherence to ensure accurate data collection over the study period.

Researchers are evaluating the clinical performance and long-term safety of bioabsorbable scaffold implantation for treating coronary artery disease in a real-world regional setting. This observational prospective study involves two networks of centers in the Emilia-Romagna region and the MAGIC retrospective study participants, working together under a unified protocol. The study aims to address limitations of current permanent metallic stents, such as thrombosis and restenosis, by investigating newer scaffold devices. Participants will receive scaffold implantation, including devices like Magmaris or Desolve, following specific strategies agreed upon by investigators. These include mandatory predilatation, 1:1 sizing, avoiding vessels with diameters outside 2.8 to 3.8 mm or severe calcifications, and mandatory postdilation with a non-compliant balloon at least 0.5 mm larger than the scaffold diameter. The study focuses on patients under 65 years, complete revascularization, long lesions especially in the left anterior descending artery, and spontaneous coronary dissection. During the study, all adverse events will be monitored continuously by a Data Safety Monitoring Board. Coronary angiographies and interventions will be independently reviewed by a core laboratory to assess implantation techniques and outcomes. The primary outcome is the occurrence of device-oriented cardiac events over one year. Participants must provide informed consent and agree to at least one year of follow-up and compliance with dual antiplatelet therapy. The study duration includes enrollment and a one-year follow-up period.