Seri Kembangan

This research aims to monitor and collect information on medical problems, known as adverse events, that occur after vaccination with the QDENGA vaccine in Malaysia. The study also seeks to understand how many vaccinated individuals may require hospital stays due to severe dengue fever. The study focuses on people who have already received the QDENGA vaccine and agree to participate. There is no treatment or vaccination given as part of this study. It is a non-interventional study, meaning researchers only collect data without administering any new treatments or vaccines. Participants have already been vaccinated with QDENGA before joining the study. Participants will be monitored for any adverse events and serious adverse events starting from 14 days after their first vaccination and continuing for up to 15 months. The study collects safety information through follow-up and tracking of medical issues related to the vaccine over this period, but no additional interventions or procedures are performed.

This research aims to compare the effects of four different relaxation techniques on both physical and psychological outcomes in breastfeeding mothers of preterm infants born between 28 and 35 weeks gestation. The study focuses on lactating mothers aged 18 to 49 years who are Muslim, non-smokers, and without medical conditions affecting breastfeeding or mental illness. The goal is to find which relaxation intervention best supports the well-being of these mothers. Participants will experience five separate sessions, each testing one of the following interventions: Guided Imagery Meditation (10-14 minutes of audio meditation), Religious Recitation (14 minutes of listening to Surah Ar-Rahman), Infant Video with Music (10 minutes of infant images and video with music), Distraction with News and Media (10 minutes of phone use), and a Control session where participants sit quietly for 10 minutes with minimal distractions. Each session will be spaced 1 to 2 days apart, and the order of sessions will be randomized. Throughout the study, researchers will monitor heart rate, blood pressure, fingertip temperature, breast milk cortisol levels, and perceived relaxation from enrollment through the end of the five sessions within two weeks. Participants will be assessed for changes in these physiological and psychological measures to evaluate the effects of each relaxation technique on their well-being during this period.

Researchers are evaluating the effects of date seed extract on blood sugar control and cardiovascular risk in adults with Type 2 diabetes in Riyadh, Saudi Arabia. Diabetes is a growing health concern worldwide and particularly in Saudi Arabia, where a significant portion of the population is affected. This study aims to fill the gap in knowledge about how consuming date seed powder might help manage blood sugar levels and reduce heart-related risks among people with diabetes. Participants will be randomly assigned to one of two groups: an intervention group that takes capsules containing date seed powder and a control group that does not receive any capsules. Those in the intervention group will consume two capsules, totaling 5 grams of date seed powder, twice daily after meals for three months. The study includes regular assessments at the start, one month, and two months after the intervention period to monitor health changes and ensure adherence to the treatment plan. Throughout the study, participants will complete questionnaires covering lifestyle and clinical information. Researchers will collect physical measurements such as blood pressure and body measurements, as well as laboratory tests including blood glucose and cholesterol levels. Participants will be contacted twice weekly to support adherence and address any questions. The main outcomes measured are changes in blood sugar, cholesterol, and blood pressure from baseline to 12 weeks after starting the intervention.

This research aims to develop and assess an educational program to improve dietitians' knowledge, attitudes, and practices regarding renal nutrition for patients with chronic kidney disease (CKD) in public hospitals in Saudi Arabia. The study expects that dietitians who participate in the education program will show significant improvements compared to those who do not. The results will help enhance dietitians' ability to provide effective nutritional care for CKD patients in the region. A cluster randomized controlled trial will be conducted involving 100 dietitians divided equally into intervention and control groups. The intervention consists of a five-week education program delivered online via Zoom, including lectures, workshops, brainstorming, and case studies. The program covers topics such as nutrition assessment for CKD, malnutrition, nutrient deficiencies, nutrition intervention, and counseling skills, using various materials like videos, booklets, and posters. This program is developed based on evidence-based guidelines and delivered in collaboration with hospital nutrition departments. Participants will be interviewed and assessed on their renal nutrition competencies at three time points: before the program begins (baseline), immediately after the intervention (one week post-intervention), and three months later. Data will be gathered using a specialized questionnaire and analyzed with statistical software to measure changes in knowledge, attitude, and practice. The study will monitor improvements over time to evaluate the program's impact and support dietitians' ongoing professional development.

Dental caries is a widespread public health problem that particularly affects children, impacting their health, development, and well-being. This research aims to assess a school-based oral health education program in Al Lith City, Saudi Arabia, that targets male primary school children aged 10 to 11 years. The study focuses on improving children's knowledge, attitudes, and behaviors related to oral health to address inadequate oral hygiene and eating habits that worsen dental caries outcomes. The program involves interactive classroom sessions led by a dental care professional over one school term. The first sessions aim to increase knowledge and positive attitudes about oral health and healthy eating. Subsequent sessions focus on building practical skills to help children apply what they have learned to improve oral hygiene and eating behaviors. The effectiveness of this intervention will be measured before the program starts, then at two months and four months after the intervention using a questionnaire. Participants will complete questionnaires assessing their knowledge, attitudes, and oral health practices at baseline, immediately after, and six months post-intervention. Researchers will analyze the data using statistical methods to understand changes and effects of the program. The study expects that this school-based education will enhance children's oral health knowledge, some hygiene behaviors, and positively influence eating habits and patterns.

Researchers are conducting a 2-year, multicenter observational study to evaluate clinical differences in patients with migraine who are treated with medications targeting calcitonin gene-related peptide (CGRP) or its receptor. These medications include monoclonal antibodies such as erenumab, galcanezumab, fremanezumab, and eptinezumab, as well as gepants like rimegepant and atogepant. The study includes patients diagnosed with migraine according to specific criteria and who meet local reimbursement guidelines for these treatments. Participants will begin treatment with one of the anti-CGRP drugs or gepants, and a baseline assessment will be performed. Follow-up visits will occur every 6 months to monitor treatment effectiveness, side effects, patient-reported outcomes, and eligibility to continue the study medication. The observation period for each participant will last for 2 years. During the study, researchers will track changes in the number of monthly headache days and monthly migraine days as primary outcomes. Participants will undergo regular assessments including clinical evaluations and questionnaires. Safety and treatment adherence will be monitored throughout the two-year observation period to better understand real-world use of these migraine preventive therapies.

Researchers are evaluating an ergonomics intervention program aimed at reducing work-related musculoskeletal disorders (MSDs) among dental healthcare workers in Dubai government hospitals. These MSDs affect up to 90% of dental professionals in the area, mainly impacting the lower back, neck, shoulders, and upper limbs due to repetitive tasks and sustained postures. The study uses a cluster randomized controlled trial (RCT) design across three hospitals to assess the effectiveness of the intervention in improving MSD prevalence and severity, mental health, physical activity, and knowledge, attitudes, and practices (KAP) scores. The intervention program is based on Social Cognitive Theory and includes educational booklets, lectures, workshops, demonstrations, practical exercises, and stretching sessions delivered over six weekly teaching units lasting 45-60 minutes each. Topics cover understanding MSD causes, ergonomic principles, equipment positioning, early symptom recognition, rest breaks, and promoting physical activity. The study compares outcomes between an intervention group and a control group, each with 55 participants. Participants will be assessed at baseline, one month post-intervention, and at a three-month follow-up. Researchers will evaluate changes in MSD symptoms, mental health impact, physical activity levels, and KAP scores using statistical analyses like logistic regression, ANOVA, and Generalized Estimating Equations. The study aims to identify key risk factors and demonstrate the program's effectiveness in improving occupational health among dental workers, informing future health policies in the UAE.

Metabolic syndrome is a widespread health condition characterized by a combination of risk factors including abdominal obesity, high blood pressure, elevated blood sugar, high triglycerides, and low HDL cholesterol. These factors significantly raise the risk of cardiovascular disease, type 2 diabetes, and death. In Saudi Arabia, a high prevalence of metabolic syndrome has been reported, particularly in northern and central regions and among men. Although weight loss, intermittent fasting, and increased physical activity have shown benefits internationally, no randomized controlled trials have yet examined their combined effects on metabolic syndrome markers in Saudi adults. This trial evaluates how intermittent fasting, caloric restriction, and physical activity affect metabolic syndrome biomarkers, body composition, and lifestyle in adults diagnosed with metabolic syndrome in Riyadh. Participants will be randomly assigned to either an intervention group, which will follow a modified intermittent fasting protocol (16 hours fasting and 8 hours eating daily), a calorie-restricted diet tailored to their needs, and at least 150 minutes per week of moderate aerobic activity, or to a control group receiving standard hospital care. Participants will be assessed at baseline, week 4, week 8, and week 12 for changes in blood glucose, cholesterol, blood pressure, body mass index, physical activity, and dietary intake. The study will use questionnaires, physical measures, and a mobile app to monitor adherence to exercise recommendations. These repeated measurements aim to compare the effectiveness of the intervention on improving metabolic syndrome markers and lifestyle habits over a 12-week period.