Kristiansund

This trial focuses on elderly patients aged 80 years or older, or those 75 years and older who are considered frail, with untreated diffuse large B-cell lymphoma DLBCL and related lymphoma subtypes. The study is a phase III, randomized, open-label, multicenter trial conducted in several countries including Sweden, Norway, Finland, Denmark, Italy, Australia, and New Zealand. It aims to compare the standard chemotherapy regimen R-miniCHOP with an experimental treatment R-pola-miniCHP, where vincristine is replaced by polatuzumab vedotin, to assess differences in outcomes for this patient population. Participants will be randomly assigned to one of two treatment groups. One group will receive R-mini-CHOP consisting of rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone over six 21-day cycles. The other group will receive R-pola-mini-CHP, which includes rituximab, cyclophosphamide, doxorubicin, prednisone, and polatuzumab vedotin instead of vincristine, also given over six 21-day cycles. Both treatments last approximately 18 weeks. The study includes a screening period lasting up to 4 weeks before treatment begins. During the study, participants will be followed for up to 36 months after completing treatment to monitor progression-free survival over two years. Researchers will evaluate disease progression and safety outcomes through regular assessments during and after the treatment period. Participants will provide informed consent and undergo evaluations including health status and disease measurements to ensure eligibility and monitor treatment effects throughout the trial.

Substance use disorder SUD is a serious condition linked to a high global health burden, with limited approved drug treatments available. This research explores the long-term effects of music therapy as a non-drug approach to support people with SUD. The study is a large, international randomized clinical trial comparing different music therapy methods alongside usual treatment. It aims to see how these therapies affect addiction severity one year after starting. Participants are randomly assigned to one of three groups an Active Music Group AMG where they actively make music in sessions led by trained music therapists a Music Listening Group MLG where they listen to music in group sessions or Treatment as Usual TAU, which includes local standard care that may involve various therapies or medications. Both AMG and MLG sessions happen weekly and last up to 90 minutes, while all participants continue any usual care provided locally. During the study, participants will be assessed using various tools at baseline, 1 year, and 2 years to measure addiction severity, recovery, substance use, quality of life, depression, motivation, craving, social connectedness, cognition, creativity, and brain health. Additional monitoring includes public records for employment, hospitalizations, criminal records, and survival for up to 10 years. This comprehensive follow-up helps understand the long-term impact of music therapy on SUD.

Researchers are evaluating a new model for interaction across health services using welfare technology and telemedicine. This model aims to improve how patient information and care routines are exchanged between the municipality and the hospital. It is first being tested for intravenous antibiotic therapy at home and seeks to provide knowledge that can be applied to other conditions, treatments, and areas. The study involves patients who need intravenous antibiotics but are treated at home instead of being admitted to the hospital. They are monitored by the municipal regional response center and nurses following an individual treatment plan, with hospital physicians remaining medically responsible. The approach includes interviews, observations, and data collection from hospital records, alarm systems, and infusion pump logs to develop and assess the service. Participants will be followed over 45 months, during which researchers will measure the number of rehospitalizations, patient satisfaction, and health personnels views on patient safety. Data will be collected from patient records and communication systems. Patients must be trained to manage their infusion pumps and communicate with the response center. The study is designed to ensure safety and quality of home antibiotic treatment through ongoing monitoring and evaluation.

Researchers are evaluating the use of ancillary screws in the ACE acetabulum cup of a total hip replacement surgery for patients aged 65 to 80 with hip osteoarthritis. The study aims to compare implant migration and early fixation of a hybrid hip replacement combining an uncemented ACE acetabular component with a cemented Avanteon femoral stem. This is done using a new CT-based Radiostereometric Analysis CT-RSA method, which may help predict the long-term survival of these implants and reduce the need for revision surgeries. Participants will undergo total hip arthroplasty and be randomly assigned to receive either the acetabular component with ancillary screws or without screws. The study will use CT-RSA, plain X-rays, and patient-reported outcome measures to assess implant stability and migration over time. Additionally, patient activity will be monitored with an accelerometer-based device to evaluate if screw fixation affects activity levels. The study also aims to test the precision of an ultra-low dose CT-RSA to reduce radiation exposure. During the study, participants will have scheduled clinical and radiographic evaluations including CT scans and X-rays at regular intervals over two years. Researchers will measure implant translation, rotation, and migration to assess fixation and stability. Patient activity levels and safety will also be monitored. The goal is to provide data that supports improvements in hip implant design and durability, potentially reducing revision surgery and associated complications. Total participation lasts at least two years with ongoing assessments and monitoring.

Researchers are conducting an observational study to understand how new immunotherapies are used in treating multiple myeloma and related conditions in Norway. The study aims to fill knowledge gaps, provide evidence for future trials, and help develop guidelines for monitoring and managing side effects to improve patient survival and quality of life. This research focuses on patients with multiple myeloma, primary plasma cell leukemia, and AL amyloidosis. Participants are observed while receiving immunotherapies including Teclistamab, Elranatamab, Talquetamab, Idecabtagene vicleucel, and Ciltacabtagene Autoleucel as part of their routine care outside of clinical trials. The study monitors how these treatments are used in real-world settings, including dosing and administration. There is no assigned treatment group or placebo instead, the study collects data on treatments given during regular healthcare. Throughout the study, participants response to treatment, progression-free survival, time to next treatment, overall survival, and adverse events are tracked for up to ten years. Researchers collect data on infections, antibiotic resistance, airway viruses, and use of antimicrobial prophylaxis during therapy. This long-term monitoring aims to provide comprehensive safety and effectiveness information to guide future care and research.

Researchers are comparing two surgical techniques for total knee arthroplasty TKA in patients with knee osteoarthritis. The study evaluates the traditional mechanical alignment method, which aims for a neutral knee position, against a personalized approach called kinematic alignment that tries to restore the patients natural knee anatomy. This trial uses robotic-assisted surgery to improve precision and aims to determine if personalized alignment offers equal or better implant longevity and clinical outcomes. Participants will undergo knee replacement surgery using the ROSA Knee System robot and receive either mechanical alignment or personalized alignment. The tibial implant placement will be controlled within specific angles to ensure safety. This randomized, triple-blinded trial involves 152 patients and focuses on comparing the stability, position, and clinical outcomes of implants placed using these two alignment methods. During the study, participants will be assessed through clinical tests and specialized CT scans to measure implant migration and stability over two years. Researchers will also evaluate physical activity, strength, walking, stair climbing, and patient-reported outcomes at one and two years after surgery. The study includes safety monitoring for potential complications related to robotic surgery, such as fractures or infections, with follow-up lasting until 2035.