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Found 4 Actively Recruiting clinical trials

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Actively Recruiting

Researchers are evaluating the effect of adding dexmedetomidine to bupivacaine for pain relief after abdominal surgeries. This randomized controlled trial involves 80 patients aged 21 to 45 undergoing elective abdominal surgeries such as exploratory laparotomy, ileostomy reversal, cholecystectomy, or hernia repair. The study compares pain control and side effects between two groups to see if dexmedetomidine improves analgesia without increasing complications. Participants are randomly assigned to one of two groups. One group receives a combination of 0.25% bupivacaine and dexmedetomidine via an ultrasound-guided transversus abdominis plane TAP block at the end of surgery. The other group receives only 0.25% bupivacaine using the same TAP block method. Both groups are monitored for pain relief and other effects over 12 hours post-surgery. During the study, pain levels are measured using the Visual Analogue Scale VAS at multiple time points between 1 and 12 hours after surgery. Researchers also assess sedation using the Ramsay Sedation Scale and monitor vital signs like heart rate and blood pressure. Side effects such as hypotension, bradycardia, and nausea are recorded. Rescue pain medication is given if pain scores exceed 4. Data will be analyzed to determine if dexmedetomidine provides better pain control without increasing side effects.

Age: 21Years - 45YearsAll GendersPhase Not Applicable
1 location
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Actively Recruiting

Low back pain LBP is a common issue affecting 50-70% of pregnant women, especially in the second and third trimesters, due to physiological and biomechanical changes like ligament relaxation and postural shifts. This research aims to evaluate the combined effect of prenatal stretching and kinesiotaping on pain, mobility, and quality of life in pregnant women with LBP. The study is a randomized controlled trial conducted at Rahim Yar Khan hospital and Hamdani Hospital Rahim Yar Khan, focusing on women aged 18 to 35 years with a gestational age between 20 and 34 weeks who experience low back pain. Participants will be randomly assigned to one of two groups. Group A will receive prenatal stretching exercises under supervision three times per week for sessions lasting about 30 minutes, along with kinesiotaping applied by a certified professional to the lumbar region. The tape will stay on for 3 to 5 days and be reapplied regularly over the 4 to 6-week intervention period. Group B will perform the same stretching exercises without kinesiotaping. Both groups will be monitored regularly to ensure adherence and identify any adverse effects during the 6 to 8-week study duration. Throughout the study, participants will undergo baseline and post-intervention assessments measuring pain using a 10 cm Numeric Pain Rating Scale, mobility through the Schober Test, and quality of life via the SF-36 questionnaire. Researchers will collect and analyze data using SPSS software. The study includes informed consent, regular monitoring, and evaluation to assess how these interventions impact pregnant womens low back pain and related outcomes.

Age: 18Years - 35YearsFEMALEPhase Not Applicable
1 location
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Actively Recruiting

Researchers are evaluating the effectiveness of Mindfulness-Based Cognitive Therapy MBCT in reducing psychological distress among psoriasis patients. This study also aims to improve patients self-compassion and explore changes in their Mental Health Locus of Control MHLC, which reflects how much control they believe they have over their health. The study addresses the emotional and psychological challenges that many psoriasis patients face, such as stress, anxiety, depression, and self-judgment, which are often not fully treated by standard physical care. The study involves two groups one receiving the MBCT intervention and the other receiving usual care without MBCT. MBCT combines mindfulness practices with cognitive behavioral techniques delivered in structured sessions to help patients become more self-aware, reduce negative thinking, and develop self-compassion. The research follows a randomized design, assessing baseline psychological distress, MHLC, and self-compassion before implementing the MBCT intervention and evaluating its effects. Participants will be involved over a 12-week period during which researchers will measure reductions in psychological distress as the primary outcome. The study also examines improvements in self-compassion and shifts in locus of control. Assessments will include psychological evaluations at the start and after treatment to monitor emotional well-being and coping. The study is sponsored by Islamia University of Bahawalpur and aims to enhance integrated care for psoriasis by focusing on psychological health alongside physical symptoms.

Age: 25Years - 75YearsAll GendersPhase Not Applicable
1 location
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Actively Recruiting

This research aims to reduce child malnutrition in Pakistan by building on local community strengths and practical solutions. It focuses on children aged 7 to 23 months, prioritizing those 7 to 15 months old so they can be followed over 6 to 12 months. The project combines community sensitization with a behavior change program to promote healthy feeding, hygiene, and caregiving practices, addressing chronic malnutrition through sustainable family engagement rather than short-term aid. The intervention includes community sensitization events where families learn about healthy feeding through discussions and printed visuals. The main intervention is a 28-day behavior change program starting with two weeks of daily Hearth sessions, interactive group meetings teaching practical skills in a home-like setting, followed by two weeks of home visits where mothers practice new skills with staff support. Children who meet growth targets graduate to monthly check-ins, while others may repeat the cycle up to three times. Control group families continue usual care without the behavior program. Participants undergo health checks before starting, and mothers provide consent. Researchers collect surveys and measure childrens height and weight at baseline, during the program, and monthly follow-ups for six months. They assess child growth, feeding, hygiene, and caregiving behaviors using validated tools. Educational materials with visuals support learning for all literacy levels. The project aims to empower families to use local resources for lasting improvements in child nutrition and care.

Age: 7Months - 15MonthsAll GendersPhase Not Applicable
1 location