Covilha

Researchers are investigating the effects of kombucha, a fermented tea beverage, on individuals who are overweight or have class 1 obesity. The study focuses on how kombucha impacts gut microbiota composition, metabolic parameters such as glucose and insulin levels, lipid profiles, and liver function. Previous animal studies suggested potential benefits, but this clinical study aims to provide stronger evidence in humans through a randomized controlled pilot trial. Participants will be randomly assigned to one of three groups: one group will consume 33 cl of live (non-pasteurized, non-filtered) kombucha daily, another will consume 33 cl of pasteurized kombucha daily, and the control group will receive 33 cl of sparkling water daily. Each intervention lasts for 4 weeks (28 days), allowing comparison between the effects of live versus pasteurized kombucha and the control on health markers. During the 4-week study, participants will provide fecal samples to analyze gut microbiota changes and undergo measurements of fasting glucose, insulin levels, insulin resistance (HOMA-IR), and lipid profiles. The study will monitor these outcomes to evaluate the metabolic and microbiome effects of kombucha consumption. Participants must comply with the study protocol and attend scheduled assessments throughout the study period.

Researchers are investigating how a sleep behavioral intervention combined with standard obesity treatment affects adolescents aged 13 to 17 years who have overweight or obesity and poor sleep quality. The study aims to understand if improving sleep can help reduce body fat and improve related health risks like insulin resistance and hypertension. This trial also explores effects on sleep patterns, eating habits, physical activity, emotional well-being, self-compassion, quality of life, and certain hormone and metabolic levels linked to obesity and sleep. This randomized controlled trial will enroll 126 adolescents who will be assigned to either the intervention group receiving a sleep behavioral program plus standard obesity treatment or the control group receiving only the standard obesity treatment. The sleep program includes seven cognitive-behavioral therapy sessions over six months, focusing on sleep hygiene, self-monitoring, stimulus control, cognitive therapy, and relaxation techniques. Both groups receive regular medical consultations addressing nutrition, physical activity, and lifestyle every two months during the intervention and every three months during a six-month follow-up. Participants will undergo assessments including body measurements, blood pressure, body composition, and blood tests at baseline, six months, and twelve months. Sleep will be objectively measured using actigraphy and ambulatory sleep studies. Questionnaires will evaluate sleep, diet, physical activity, quality of life, emotional health, and self-compassion. Researchers will track changes in BMI, fat mass, fat-free mass, and metabolic markers, while monitoring safety and adherence over a total period of one year.

Researchers are studying how different amounts of resistance training affect people with mild cognitive impairment, focusing on areas like cognitive function, oxidative stress, immune response, blood fats, blood sugar control, liver health, muscle strength, blood pressure, and physical abilities. The study first looks at the immediate effects of single resistance training sessions with one set or three sets of exercises on blood pressure and physical performance. Then, it examines the results of an eight-week training program with either one or three sets per exercise to see how these affect various health markers and physical function over time. Participants will take part in two phases. In the acute phase, they perform two different resistance training sessions one week apart: one with one set per exercise and another with three sets. Each session includes warm-up walking, leg press, chest press, sit-to-stand, medicine ball throw, and treadmill walking at specific intensities. In the eight-week phase, participants are assigned to either one set or three sets per exercise, following a similar training routine. A control group will continue their usual daily activities without exercise. Throughout the study, participants will be assessed before, immediately after, and 72 hours after training sessions for changes in blood pressure, heart rate, temperature, and muscle strength. Cognitive testing, blood tests, and physical performance evaluations will be done before and after the eight-week program to measure improvements or changes. The study monitors safety and measures outcomes like blood pressure, handgrip strength, cognitive scales, brain factors, and physical performance over the course of the trial.