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The registry focuses on patients with venous thromboembolism VTE, including those often excluded from typical clinical trials such as pregnant women, elderly patients, and those with serious health conditions. It aims to improve medical knowledge and patient care by collecting detailed data on these patients clinical status and treatment outcomes. The project also seeks to develop predictive scores to identify patients at higher risk of complications from thromboembolic disease. This observational registry collects extensive information on patients diagnosed with VTE, including details on coexisting conditions, antithrombotic treatment type, dose, and duration, as well as outcomes during the first three months of therapy. It captures data on VTE recurrences, bleeding complications, and deaths, providing insights into real-world treatment and patient management. Participants provide informed consent and are followed for at least three months to monitor clinical outcomes. The registry supports physicians by giving access to data on patients with similar profiles to help manage complex cases. The main outcomes measured include VTE events and complications over a three-year period, supporting ongoing improvements in patient care and risk assessment.

Researchers are developing and validating a predictive model to understand the risk of acquiring sexually transmitted infections STIs among individuals using HIV pre-exposure prophylaxis PrEP within Spains national program. This observational study includes PrEP users followed according to national protocols at 23 hospitals. The study focuses on STIs such as syphilis, gonorrhea, chlamydia, herpes, hepatitis, HIV, and MPOX, with the primary outcome being whether participants develop an STI. Participants are individuals who have started daily oral PrEP, have taken at least one pill, and meet the approved criteria by Spanish guidelines. They will be monitored quarterly with tests including blood samples and swabs from various sites to diagnose STIs. The study uses data from these visits to build and validate predictive models and analyze factors linked to STI acquisition. Participants will be followed over an average of five years with regular clinical visits to monitor for STIs and collect behavioral and adherence data. Researchers will measure the occurrence and number of STIs, changes in behavior, PrEP adherence, and discontinuation rates. The study aims to improve understanding of STI dynamics among PrEP users while ensuring ongoing monitoring and data collection throughout the participation period.

Researchers are examining the use of dexamethasone in adults with acute hypoxemic respiratory failure AHRF, including acute respiratory distress syndrome ARDS, caused by infections such as COVID-19. This condition leads to severe lung inflammation requiring mechanical ventilation and has high mortality rates. The effectiveness of corticosteroids like dexamethasone in treating AHRF and ARDS remains uncertain, prompting this study to compare different dosing strategies to better understand their impact on patient outcomes. The trial is a randomized, controlled, open-label study conducted across multiple centers in Spain. Participants who are mechanically ventilated with confirmed infection-related AHRF will be assigned to receive either a low dose of dexamethasone 6 mg daily for 10 days or a higher dose 20 mg daily for 5 days, followed by 10 mg daily for 5 days. The study compares these two dosing regimens to determine which may better reduce mortality and improve ventilator-free days. During the trial, participants will be closely monitored in intensive care units, with primary outcomes measured by mortality at 60 days and secondary outcomes by the number of days free from mechanical ventilation within 28 days. Researchers will gather data on lung function, infection status, and overall health. Participants progress will be followed to assess the safety and effects of the dexamethasone doses over the study period.

Researchers are investigating the effects of nut consumption on mental health in young adults aged 18 to 24, a critical stage for mental health development. Nuts, rich in healthy fats and antioxidants, have been linked in observational studies to better mental health and mood, but experimental evidence remains limited. This trial aims to explore how a six-month mixed-nut diet affects symptoms like depression, anxiety, stress, cognitive abilities, sleep, well-being, and brain-related biochemical markers. Participants will be randomly assigned to one of three groups a control group maintaining their usual diet, or two intervention groups consuming either 30 grams or 60 grams daily of a mixed-nut blend walnuts, almonds, pistachios, and hazelnuts provided free for six months. After the intervention, all participants return to their normal diet. A final follow-up visit occurs six months after the intervention ends to collect long-term data. Throughout the study, participants will undergo assessments at the start, three months, six months, and twelve months to measure mental health symptoms including depression, anxiety, and stress, as well as cognitive functions like memory and attention. Researchers will also evaluate sleep quality, quality of life, inflammation markers, nutrient levels, body composition, physical activity, and dietary adherence. This comprehensive data collection helps monitor participant health and study outcomes over a full year.

Researchers are evaluating two training methods to improve basic life support BLS knowledge and skills among schoolchildren aged 5 to 13 years. This trial aims to determine which approach is more effective at teaching cardiopulmonary resuscitation CPR to children and adolescents in a school setting. The study is motivated by the high impact of out-of-hospital cardiorespiratory arrest and the need to increase the number of first responders trained in CPR. One group receives a 2-hour hands-on session led by nursing professionals, including practice with mannequins and instruction on using a semi-automatic defibrillator. The other group watches a short educational video and uses a puzzle to learn the CPR sequence, but without mannequin practice. Both interventions are adapted to the childrens ages and delivered within their schools. Participants will be assessed on their theoretical knowledge, practical CPR skills, and quality of CPR immediately before and after the intervention and again at an 8-month follow-up. The study also considers factors like physical condition and demographics. The total involvement includes these training sessions and evaluations, with no masking or placebo controls involved.

Researchers are conducting a long-term observational study to collect information from patients diagnosed with early-stage invasive breast cancer. These patients were previously part of neoadjuvant or adjuvant clinical trials conducted by the GEICAM group, starting from 1998. The study aims to evaluate the long-term effects and outcomes of breast cancer treatments over an extended follow-up period. The study includes patients who completed follow-up in the original GEICAM trials and will continue to monitor them for approximately 30 years. This extended observation allows researchers to assess long-term event-free survival and disease-free survival, along with overall survival, providing valuable insights into the durability of treatment effects and potential late effects. Participants will be followed regularly during this period, with data collected to track their health status and cancer outcomes. The study gathers vital information useful for healthcare professionals, hospital managers, patients, and society to better understand long-term needs and treatment impacts in early-stage invasive breast cancer. The total participation duration can be up to 30 years from the start of the study.

Researchers are conducting a national, multicenter observational study called SOGUG-PRINCIS to collect and analyze data on patients with genitourinary cancers treated with recently approved drugs under routine clinical practice in Spain. This study is both retrospective and prospective, aiming to validate real-world effectiveness of these drugs and support future funding decisions. It will serve as a registry where new subprojects will open whenever new drugs receive authorization. The study follows patients who have started treatment with specific drugs funded by the Spanish National Health System, including darolutamide combined with androgen deprivation therapy and docetaxel for hormone-sensitive prostate cancer, adjuvant nivolumab after surgery for urothelial carcinoma, and enfortumab vedotin for urothelial carcinoma. All treatments follow their approved dosing and administration guidelines and standard clinical practice. Participants progress will be monitored through routine data collection to evaluate outcomes such as progression-free survival at 18 months, relapse-free survival at 24 months, and overall survival at 12 months after starting treatment. Data will be gathered from patients treated at participating centers, with follow-up continuing as per routine care. The study does not intervene in treatment decisions, which are made independently before enrollment.

Researchers are conducting an observational, epidemiological study to understand thrombosis in patients diagnosed with cancer. This study focuses on patients who experience venous or arterial thromboembolic events, either symptomatic or incidental, occurring within a month before cancer diagnosis or any time afterward. The study collects detailed information about the characteristics and timing of these events in relation to cancer diagnosis to better understand this condition. The study does not involve any interventions or treatments, as it is non-interventional and observational. Data is gathered from multiple centers, tracking details such as the location and vessel of origin of the thromboembolic event, tumor characteristics, and treatment administered for cancer at baseline. Patients are followed up for 12 months to assess their situation and outcomes related to thrombosis and cancer. Participants are involved through data collection at baseline and follow-up visits. Researchers assess imaging-confirmed thromboembolic events using techniques like Doppler echocardiography and CT angiography. The study measures various outcomes including event diagnosis, tumor stage, timing between cancer diagnosis and thrombosis, and patient status at one year. This registry provides valuable information about cancer-associated thrombosis over time.

This research aims to collect detailed information about patients with lung cancer and other thoracic tumors to better understand the disease and treatment outcomes. It focuses on individualizing treatment based on markers that predict response to chemotherapy and molecular inhibitors. The study addresses challenges such as poor prognosis, variability in diagnosis and treatment, and the need for improved early detection and prevention strategies across Europe and Spain. The study is observational and multicenter, gathering data both retrospectively and prospectively from patients diagnosed and treated by medical professionals including thoracic surgeons and oncologists. It includes multiple groups of patients based on the type of thoracic tumor, such as non-small cell lung cancer, small cell lung cancer, mesothelioma, thymic cancer, and carcinoid cancer. There are no experimental treatments instead, it involves comprehensive data collection on patient characteristics and treatments. Participants provide information from their medical history and treatment records over up to 10 years. Researchers study epidemiological and therapeutic factors related to thoracic tumors by reviewing clinical data. The main outcome is to describe characteristics of these tumors in Spanish patients. The study involves no interventions or medications, focusing on observation and data analysis to inform future care and research.

This research aims to examine how anxiety and depression symptoms change over the course of cancer and to identify various factors that may predict these changes. These factors include sociodemographic details like age and marital status, clinical features such as tumor location and treatment type, psychological aspects like coping strategies and fear of recurrence, and physical activity levels. The study also explores how these factors relate to the need for and use of psychosocial support services in cancer patients. Participants are adult oncology patients recruited from multiple centers. They are divided into two groups those showing symptoms of anxiety or depression at the start, and those without such symptoms. Data collection occurs at three points baseline diagnosis or treatment start, 3 months, and 6 months. Participants complete standardized questionnaires and undergo medical record reviews to assess psychological symptoms, coping, quality of life, cognitive difficulties, physical activity, nutrition, support needs, and decision-making related to cancer treatment. No experimental treatments are given. During the study, participants will be monitored through self-report questionnaires and medical record reviews at each time point to track symptom changes and associated factors. The main outcomes measured are anxiety and depression symptoms at diagnosis, early evolution at 3 months, and medium-term evolution at 6 months. This observational study helps understand psychological health trajectories in cancer patients and how supportive care is utilized. The total participation spans about six months from diagnosis or treatment initiation.