Mannedorf

Researchers are exploring how bariatric surgery, including Sleeve Gastrectomy and Roux-en-Y gastric bypass, affects eating and drinking behaviors in people with obesity. The study focuses on understanding these behaviors beyond self-reported food intake by using a new device called the "drinkometer". This device measures detailed patterns of ingestive behavior, considering factors like sex differences and changes in gut hormone levels to better understand long-term effects of surgery. The study involves patients who have undergone these bariatric surgeries and uses the drinkometer to analyze their ingestive behavior up to one year and five years after surgery. It compares behaviors between males and females and examines the relationship between ingestive patterns and gut hormones. The research also looks at how these behavior changes relate to weight loss after surgery, especially five years after Roux-en-Y gastric bypass. Participants will be monitored using the drinkometer device and will have their gut hormone levels measured after meals. The study tracks changes in ingestive behavior, body weight loss, and hormone levels over time. Researchers will use these measurements to identify patterns and clusters of behavior and assess how these relate to surgery outcomes. This study aims to provide new insights into how bariatric surgery influences eating behavior and its biological mechanisms over the long term.

Gastroentero-pancreatic neuroendocrine tumors (GEP-NETs) are rare tumors that arise from the neuroendocrine system in the gastrointestinal tract and pancreas. This registry study aims to better understand these tumors by collecting detailed clinical information from patients diagnosed with GEP-NETs in Switzerland. Since limited knowledge exists about the biology and treatment of these tumors, the study focuses on gathering data to improve understanding and management strategies. Patients with a confirmed diagnosis of neuroendocrine tumors from any location who agree to participate will have their information entered prospectively into a secure, anonymized database. Data collection involves visits from study nurses to healthcare centers, where patient files are reviewed and information is recorded. There are no specific treatments assigned by this registry; instead, it tracks various treatment approaches used in Switzerland. Participants contribute data that includes tumor types, treatments received, and outcomes such as mortality and hospitalization rates. The study reviews and evaluates this information regularly to identify patterns and assess patient outcomes over time. The main outcome measured is tumor-related mortality every five years, helping to monitor long-term effects. This registry allows for improved knowledge sharing across hospitals and practitioners in Switzerland to enhance care for patients with neuroendocrine tumors.

Researchers are investigating the differences in complications during and after thyroid removal surgery (thyroidectomy) in patients with thyroid overactivity caused by Graves' disease or Amiodarone-induced thyrotoxicosis (AIT). The study aims to determine whether patients undergoing surgery have similar complication rates depending on their thyroid hormone levels before or during the operation. This prospective observational trial uses data collected in the EUROCRINE registry to better understand risks and potentially improve treatment guidelines for these conditions. Participants will undergo thyroidectomy as part of their usual clinical care without changes to their treatment before or after surgery. Patients are grouped based on whether their thyroid hormone levels are controlled (normal) or uncontrolled (elevated) prior to surgery, assessed using free triiodothyronine (fT3) and free thyroxine (fT4) tests done within one week before the procedure. The study will include approximately 25 centers across Europe, with data collected securely online through the EUROCRINE registry and an add-on module for study-specific information. During the study, researchers will collect detailed information on surgical complications such as nerve injury, low calcium levels, bleeding, and severe heart events, along with surgery duration and hospital stay length. Data on preoperative medications and monitoring techniques will also be recorded. Participants will be followed for an average of two years after surgery to observe any complications. The findings aim to clarify if surgery can proceed safely without waiting for thyroid hormone levels to normalize, potentially reducing wait times and risks from prolonged hormone imbalance.