Damascus

Researchers are evaluating the periodontal response of teeth prepared with a biologically oriented preparation technique (BOPT) compared to a conventional preparation method for all-ceramic crowns. This study focuses on the clinical performance of crowns on teeth prepared with these two different techniques to better understand their effects on gum health and crown stability. The study involves 60 teeth divided into two groups: 30 teeth prepared using the BOPT technique and 30 teeth prepared with conventional shoulder margins. All teeth will receive either monolithic or bi-layered ceramic crowns. Follow-up visits are scheduled at 3, 6, 12, and 18 months after crown cementation to monitor outcomes. Participants will have various assessments during follow-up visits including measurements of plaque index, gingival index, probing depth, bleeding on probing, gingival marginal stability, and free gingiva thickness at 1 week, 1, 3, 6, 12, and 18 months after crown placement. Researchers will also record patient opinions and any mechanical or biological complications to evaluate the treatment's safety and effectiveness over time.

Researchers are evaluating the effects of carbohydrate loading before surgery in diabetic type 2 patients undergoing coronary artery bypass grafting (CABG) surgery with cardiopulmonary bypass. Enhanced recovery after surgery protocols aim to improve perioperative care and surgical outcomes, but while carbohydrate loading has shown benefits in reducing insulin resistance in non-diabetic patients, its effects in diabetic type 2 patients undergoing CABG are not well understood. This study seeks to fill that knowledge gap by examining physiological and clinical outcomes in this group. Participants will be randomly assigned to one of two groups. The first group will receive carbohydrate loading 2 hours before surgery, consisting of 400 ml of 12.5% maltodextrin and 400 ml of a fruit-based lemonade. The second group will follow the traditional fasting protocol, refraining from food and drink for 8 hours before surgery. This comparison aims to assess differences in insulin resistance, clinical outcomes, and inflammatory markers. During the study, patients will undergo a Short Insulin Tolerance Test before surgery and up to 72 hours afterward to measure insulin resistance. Researchers will also monitor clinical outcomes such as infection rates, length of ICU stay, and the need for inotropic and vasoactive medications. Changes in inflammatory markers, including C-reactive protein (CRP) levels, will be evaluated to understand the impact of carbohydrate loading on inflammation and recovery after surgery.

This clinical trial investigates the use of two different methods to improve soft tissue around single dental implants in the front upper jaw area, focusing on patients missing one tooth. The study compares a traditional method using connective tissue grafts taken from the patient's palate with a newer method using a xenogeneic collagen matrix (XCM), aiming to see if the less invasive XCM can provide similar results while reducing discomfort and surgical time. Participants are adults aged 18 to 60 with good oral hygiene, adequate bone, and sufficient keratinized tissue in the implant area. Participants undergo a full digital planning process including CBCT imaging, intraoral scanning, and custom surgical guide and provisional restoration fabrication. During surgery, after implant placement, patients are randomly assigned to receive either a connective tissue graft harvested from the palate or an XCM graft secured to the buccal mucosa. The connective tissue graft involves an additional surgical site and suturing, while the XCM is prepared by moistening and compressing before being sutured in place. Both groups receive a screw-retained provisional restoration immediately after soft tissue augmentation. Throughout the study, researchers measure changes in the buccal soft tissue profile using digital scans taken before surgery, immediately after, and three months later. They also assess clinical parameters like keratinized tissue width, soft tissue height, probing depth, plaque, bleeding, and radiographic bone levels. Patient-reported outcomes such as pain, swelling, aesthetic satisfaction, and willingness to repeat treatment are collected. The trial duration covers the initial surgery and a three-month follow-up to evaluate tissue changes and healing.

This research aims to compare how effective chamomile extract and valerian extract are at reducing dental anxiety in healthy children aged 6 to 10 years undergoing simple tooth extraction. Dental anxiety in children can affect their oral health, behavior, and overall well-being. Herbal treatments like chamomile and valerian have shown calming effects in other medical areas, but their impact on reducing dental anxiety in children has not been fully studied. Participants will be randomly assigned to one of three groups: one receiving 1 mL of valerian root extract diluted in apple juice, another receiving 2 mL of German chamomile flower extract diluted in water, and a placebo group receiving a small amount of water. All treatments will be given 30 minutes before local anesthesia and tooth extraction. The study investigates whether these herbal supplements can safely and effectively ease children's anxiety during dental procedures. Children's anxiety will be measured using self-reported scales at various times before and during the dental procedure, observer-rated behavior scales, and physiological measures such as blood pressure and heart rate. Researchers will monitor anxiety levels before administering the herbal extract, after 30 minutes, during local anesthesia and tooth extraction, and immediately after extraction. The study will provide detailed insights into how these herbal extracts affect both psychological and physical signs of dental anxiety in children.