Damascus

This research aims to understand how Pulmonary Endarterectomy PEA affects patients with chronic thromboembolic pulmonary hypertension CTEPH in terms of their confidence managing their condition. The study focuses on three areas of self-efficacy communication with doctors, managing chronic disease tasks, and controlling symptoms and daily functioning. Researchers want to see how improvements in these areas relate to physical abilities like walking longer distances, measured by the 6-minute walk test. Participants in this observational study are patients diagnosed with CTEPH who are scheduled for surgical PEA. There is no experimental treatment or placebo instead, researchers observe changes before and after surgery. Self-efficacy will be assessed before the operation and again six months later using several questionnaires designed to measure confidence in managing health and interacting with healthcare providers. During the study, participants will complete questionnaires such as the 10-item Perceived Efficacy in Patient-Physician Interaction Scale, the 6-item Self-Efficacy for Managing Chronic Diseases Scale, and Sullivans cardiac self-efficacy 13-item scale. Their physical ability will be tested using the 6-minute walk test at the same time points. The study will analyze how psychological changes after surgery relate to physical improvements, aiming to identify patients who may need extra psychological or rehabilitation support for better recovery.

This research aims to evaluate the gum and tissue response of teeth prepared with two different dental techniques for all-ceramic crowns the biologically oriented preparation technique BOPT and the conventional shoulder margin preparation. The study compares the clinical performance of these two methods in a randomized controlled setting involving 60 teeth divided evenly between the two groups. Participants will receive either the BOPT or the conventional preparation, followed by the placement of monolithic or bi-layered ceramic crowns. The study includes follow-up visits scheduled at 3, 6, 12, and 18 months after crown cementation to monitor various clinical parameters and patient experiences. During the study, researchers will assess plaque index, gingival index, probing depth, bleeding on probing, gingival marginal stability, and free gingiva thickness at multiple time points from 1 week up to 18 months after cementation. Other factors like crown adaptation, mechanical and functional complications, secondary caries, color matching, clinical success, and patient satisfaction will also be recorded. Participants are expected to attend all follow-up visits for thorough assessments throughout the study duration.

This research aims to compare the effects of Liquid Platelet-Rich Fibrin and Low-Level Laser Therapy on healing and relapse after lip repositioning surgery, a treatment for gummy smile caused mainly by upper lip hypermobility. The study addresses challenges such as pain, swelling, delayed healing, and relapse that can affect esthetic and functional outcomes. It explores whether these adjunctive techniques can improve healing and reduce relapse rates after surgery. Participants will be randomly assigned to one of two groups. One group will receive lip repositioning surgery followed by immediate injection of Liquid Platelet-Rich Fibrin along the incision margins. The other group will undergo the same surgery followed by application of low-level laser therapy immediately after surgery and on days 3, 7, 10, and 14 postoperatively. Both groups have similar surgical procedures but differ in the postoperative healing enhancement method. Participants will be monitored for gingival display at baseline and at 1, 3, and 6 months after surgery. Wound healing will be assessed weekly for 4 weeks. Other evaluations include postoperative pain, swelling, esthetic satisfaction, upper lip external and internal length, and any complications during and after surgery. The total involvement lasts at least 6 months with regular follow-ups to measure healing progress and relapse.

Pemphigus vulgaris PV is a chronic autoimmune disorder that causes painful oral lesions and significantly reduces quality of life. This trial studies the effectiveness and safety of supportive topical treatments, including clobetasol propionate 0.05% mouthwash, photobiomodulation therapy PBMT, and their combination. The goal is to find topical therapies that help heal oral erosions, reduce pain, and potentially lower the need for systemic medications, thereby improving patient outcomes. Participants receive one of three treatments clobetasol propionate 0.05% mouthwash used three times daily for 3 minutes over 4 weeks with gradual tapering, PBMT delivered by a 650 nm diode laser twice weekly for 30 days, or a combination of both treatments given simultaneously. The laser treatment is non-invasive and applied without contact to the lesions. All treatments are administered according to standardized protocols. During the study, participants are followed with assessments on Days 7, 14, 21, 28, 42, 60, and 90. Researchers will measure disease severity using scores like the Pemphigus Disease Area Index and Oral Disease Severity Score, track corticosteroid dosages, and evaluate quality of life and anxiety or depression scales. The trial includes safety monitoring and aims to observe the healing progress and impact on systemic medication use over three months.

Researchers are evaluating the effects of carbohydrate loading before surgery in diabetic type 2 patients undergoing coronary artery bypass graft CABG surgery using cardiopulmonary bypass CPB. This study aims to understand whether giving these patients carbohydrate drinks before surgery can reduce insulin resistance and improve clinical outcomes like infection rates and ICU stay length. The research also looks at inflammatory markers such as CRP levels to better understand physiological changes. Participants are randomly assigned to one of two groups. One group will receive carbohydrate loading 2 hours before surgery, consisting of 400 ml of 12.5% maltodextrin and 400 ml of fruit-based lemonade. The other group will follow the traditional fasting protocol, avoiding food and drink for 8 hours before surgery. This randomized controlled trial compares these two approaches to assess their impact on surgery outcomes. During the study, patients will have tests like the Short Insulin Tolerance Test KITT before surgery and up to 72 hours afterward to monitor insulin resistance. Additional assessments include measuring CRP levels, arterial blood gases, operative time, cardiopulmonary bypass duration, blood loss, number of grafts performed, use of inotropic drugs, and any complications. These evaluations help researchers understand the clinical and physiological effects of carbohydrate loading during the surgical period.

Researchers are evaluating two methods to improve soft tissue around single dental implants in the front upper jaw area, focusing on people missing one tooth with enough bone and gum tissue. The study compares a traditional connective tissue graft CTG taken from the patients palate with a less invasive xenogeneic collagen matrix XCM to see if XCM can offer similar results while reducing surgery time and donor site discomfort. This trial is randomized and controlled, aiming to enhance implant esthetics and function with fewer complications. Participants undergo detailed digital planning using CBCT scans and intraoral scans to precisely place the dental implant with a surgical guide. After implant placement, they are randomly assigned to receive either the CTG harvested from the palate or the XCM graft applied to the gum. The CTG involves a second surgical site to collect tissue, while the XCM is prepared by moistening and adapting it before securing it to the gum. Both groups receive a screw-retained provisional restoration immediately after surgery to support healing and appearance. During the study, participants will have assessments at baseline, immediately after surgery, and at 3 months to measure soft tissue changes using digital models. Additional evaluations include gum health, bone loss via X-rays, patient pain and swelling reports, aesthetic satisfaction, and surgery time. Follow-up visits extend to 6 months to monitor healing, complications, and tissue condition. The study collects detailed clinical and patient-reported data to compare outcomes and guide future implant treatments.

This research aims to compare a new tissue adhesive called PeriAcryl 90 HV with conventional surgical sutures Nylon 4-0 for closing wounds after oral fibroma excisional biopsies. The study focuses on adults aged 18 to 80 with oral fibroma lesions on the lip or cheek that require biopsy. Proper wound closure and healing are critical, and sutures, while common, have drawbacks like patient discomfort and the need for removal, especially in hard-to-reach areas of the mouth. Participants will be randomly assigned to either receive the tissue adhesive, applied directly to the wound surface in two layers after biopsy, or receive traditional sutures with interrupted stitches that will be removed after 7 days. The tissue adhesive polymerizes quickly upon contact with moist tissue and does not require removal. Both treatments will be assessed under controlled conditions during the surgical procedure. During the study, researchers will measure wound healing using the Early Wound Healing Score at 7 and 14 days after surgery, and record the time taken to close the wound. They will also assess postoperative pain at multiple time points up to 7 days using a pain scale. Participants will have regular follow-up visits for these assessments, contributing to a total study duration extending until December 2027.

This research investigates how adding a video that shows a real oral environment can improve the Tell-Show-Do technique used to reduce dental anxiety in children aged 4 to 6 years. The study aims to build trust with children and lessen their fear during different dental treatment stages by using a video that explains dental procedures with child-friendly expressions and animations. Participants are randomly assigned to one of two groups one group receives the traditional Tell-Show-Do technique without visual aids, and the other group experiences an enhanced version that includes a video simulating the oral environment and dental instruments. Both groups undergo conservative restorative treatment on mandibular primary molars. The video group watches specific video segments before each clinical step, followed by verbal explanations. Throughout a single dental visit, researchers measure anxiety using heart rate and oxygen saturation levels, an observer-rated behavior scale, and the Facial Image Scale. These assessments occur at multiple points, including before treatment, during local anesthesia, rubber dam placement, handpiece use, and restorative procedures. This comprehensive monitoring helps evaluate how the video-assisted technique affects childrens anxiety during dental care.