Actively Recruiting
Led by Damascus University · Updated on 2026-03-19
50
Participants Needed
1
Research Sites
35 weeks
Total Duration
Researchers are evaluating the effects of carbohydrate loading before surgery in diabetic type 2 patients undergoing coronary artery bypass graft (CABG) surgery using cardiopulmonary bypass (CPB). This study aims to understand whether giving these patients carbohydrate drinks before surgery can reduce insulin resistance and improve clinical outcomes like infection rates and ICU stay length. The research also looks at inflammatory markers such as CRP levels to better understand physiological changes. Participants are randomly assigned to one of two groups. One group will receive carbohydrate loading 2 hours before surgery, consisting of 400 ml of 12.5% maltodextrin and 400 ml of fruit-based lemonade. The other group will follow the traditional fasting protocol, avoiding food and drink for 8 hours before surgery. This randomized controlled trial compares these two approaches to assess their impact on surgery outcomes. During the study, patients will have tests like the Short Insulin Tolerance Test (KITT) before surgery and up to 72 hours afterward to monitor insulin resistance. Additional assessments include measuring CRP levels, arterial blood gases, operative time, cardiopulmonary bypass duration, blood loss, number of grafts performed, use of inotropic drugs, and any complications. These evaluations help researchers understand the clinical and physiological effects of carbohydrate loading during the surgical period.
CONDITIONS
Efficacy of Carbohydrate Loading in Diabetic Type 2 Patients Undergoing CABG Surgery on CPB
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Complete this quick 3-step screening to check your eligibility
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Duration - Surgery day
Participants receive either carbohydrate loading 2 hours before the surgery or follow a standard fasting protocol 8 hours before surgery.
1 visit (in-person) on surgery day
Duration - Up to 72 hours postoperatively
Participants are monitored for clinical outcomes including insulin resistance, infection rates, ICU stay duration, inflammatory markers, and complications for up to 72 hours after surgery.
Assessments during hospital stay up to 72 hours
Total: 1 location
1
Damascus University Cardiac Surgery Hospital
Damascus, Syria, Mazzeh
Actively Recruiting
M
Mohammad B Izzat, FRCS(CTh)
M
Mohammad S Sioufi, MD
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
SUPPORTIVE_CARE
Number of Arms
2
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