Banqiao District

This research aims to compare the effects of two hormone therapies on menopausal symptoms including overactive bladder, sexual function, heart rate variability, arterial stiffness, atherosclerosis, sleep quality, and depression. It focuses on women with menopausal syndrome who still have their uterus and evaluates how these therapies influence autonomic function and other health aspects. Participants will receive either tibolone at a dose of 2.5 mg per day or a combination of estradiol valerate 1 mg and medroxyprogesterone acetate 2.5 mg daily. This open-label, prospective study includes baseline assessments followed by evaluations at 4 weeks and 12 weeks after starting treatment. Various hormone therapy regimens are compared to understand their therapeutic impacts. Women enrolled will complete questionnaires measuring menopausal symptoms, overactive bladder severity, sexual function, sleep quality, and depression. Additional tests include heart rate variability, arterial stiffness, and atherosclerosis examinations. These assessments are conducted at three time points: before treatment, at 4 weeks, and at 12 weeks. The study monitors changes over 3 months to evaluate the therapies' effects and safety.

The incidence of endometrial cancer is gradually increasing. Researchers are studying how measurements of endometrial blood flow and volume, obtained by sonography before surgery, relate to the outcomes of patients with endometrial cancer. The study aims to understand if preoperative blood flow characteristics can help predict patient prognosis. This research focuses on evaluating the endometrial volume, vascularity, and blood flow using sonographic techniques before surgery. These measurements include vascularity flow index (VFI), flow index (FI), and vascularization index (VI), as well as endometrial thickness. The study does not specify treatment interventions but monitors these sonographic parameters to assess their relationship with patient outcomes. Participants will be females older than 20 years diagnosed with endometrial cancer. Researchers will track the correlation between endometrial blood flow measurements and progression-free survival over 12 months. The study involves regular sonographic assessments to measure endometrial vascularity and volume. Safety monitoring and long-term follow-up are implied through the 12-month outcome measurement period.

Researchers are investigating the role of POLE mutations in women with high-risk endometrial cancer. The study aims to determine how common these mutations are and to understand their impact on survival in real-world cases. This research focuses on cases treated at a tertiary referral center to provide a clear picture of POLE mutation prevalence and significance in this condition. Women diagnosed with high-risk recurrent endometrial cancer will have their cancer analyzed for POLE mutations. The study does not involve additional treatments but focuses on analyzing existing cases and their outcomes. The analysis will help clarify the relationship between POLE mutations and the progression or recurrence of high-risk endometrial cancer. Participants will be followed to assess the prevalence of POLE mutations over two years, with survival data collected to understand the mutation's impact. The study involves reviewing clinical data and mutation analysis results to evaluate outcomes. This information will help guide future understanding and management of high-risk endometrial cancer in women.