Study of POLE Mutation in Women with High-Risk Endometrial Cancer and Its Effect on Survival

What this Trial Is About

Researchers are investigating the role of POLE mutations in women with high-risk endometrial cancer. This observational study aims to determine how common POLE mutations are in these cases and to understand their impact on survival in real-world patients. The study focuses on women who have experienced high-risk, recurrent endometrial cancer treated at a specialized referral center. Participants will undergo analysis to detect POLE mutations in their cancer tissues. The research will include survival analysis to evaluate the effect of these mutations on overall survival over a five-year period. This approach helps to clarify the significance of POLE mutations in high-risk endometrial cancer management. During the study, researchers will collect medical and genetic data from participants and monitor survival outcomes. The main outcome is the prevalence of POLE mutations over two years, with secondary outcomes addressing survival impact over five years. Participants will be observed and data collected without intervention, with the study concluding by the end of 2026.

The Role of POLE Mutation in High Risk Endometrial Cancer.