Corum Merkez

Researchers are evaluating orforglipron to measure its effects on cardiovascular outcomes in adults aged 50 and older who have atherosclerotic cardiovascular disease ASCVD andor chronic kidney disease CKD. This phase 3 study aims to compare orforglipron with a placebo to better understand its impact on major cardiovascular events over about five years. Participants will be randomly assigned to receive either orforglipron orally along with standard care or a placebo orally along with standard care. The study is double-blinded, meaning neither participants nor researchers will know who receives the active drug or placebo during the trial period. During the study, participants will be followed for around five years, with researchers monitoring the time to the first major cardiovascular event and additional outcomes such as cardiovascular and kidney events, changes in kidney function measured by eGFR, and the onset of type 2 diabetes. The study includes regular assessments to track these outcomes and ensure participant safety throughout the long-term follow-up.

This research aims to evaluate whether advanced hemodynamic monitoring using the MostCare system provides better detection and management of hemodynamic events requiring intervention compared to standard monitoring alone during propofol sedation for ERCP procedures. ERCP is a less invasive procedure used to treat biliary and pancreatic duct disorders, often performed in elderly patients who face challenges in anesthesia and sedation due to hemodynamic fragility and other health conditions. The study focuses on improving perioperative hemodynamic management to maintain adequate organ perfusion and oxygen delivery during these procedures. Participants will be assigned to one of two groups one receiving standard monitoring during ERCP sedation, which includes non-invasive blood pressure, electrocardiography, peripheral oxygen saturation, and bispectral index monitoring and the other receiving standard monitoring plus advanced hemodynamic monitoring with the MostCare system. The MostCare device uses arterial waveform analysis to continuously assess parameters like cardiac output, stroke volume, and systemic vascular resistance. Sedation will be provided with midazolam and propofol following the study protocol. During the study, participants will be monitored from the start of sedation until the end of the ERCP procedure to record hemodynamic events that require clinical intervention. Researchers will collect advanced and standard monitoring data to compare outcomes. The primary measure is the number of such events during the procedure. The study is randomized and parallel in design, with no masking, and participants health and procedure tolerance will be closely observed throughout the trial period.

Researchers are evaluating the effects of NNC0487-0111 in adults with excess body weight and obstructive sleep apnea who are not using positive airway pressure treatment. This Phase 3 trial aims to assess the safety and effectiveness of this medication in helping participants lose weight and improve their sleep apnea. The study compares NNC0487-0111 with a placebo, which is an inactive treatment given by chance to participants. Participants receive weekly injections of either NNC0487-0111 or a matching placebo under the skin using pre-filled pen injectors applied to the thigh, abdomen, or upper arm. Both groups follow a reduced-calorie diet and increase physical activity during the study. The treatment period lasts for 80 weeks, during which researchers monitor changes in body weight and sleep apnea severity. Throughout the study, participants undergo regular assessments including body weight measurements and evaluation of the apnea-hypopnea index AHI to track sleep apnea severity. Additional tests measure sleep-related impairment, blood pressure, cholesterol levels, and blood sugar control. Safety is monitored by tracking any adverse events during the 84 weeks of the study. Participants progress is carefully followed to understand the impact of the treatment on weight and sleep apnea over time.

Researchers are evaluating the effectiveness and safety of NNC0487-0111 in adults with overweight or obesity who also have obstructive sleep apnoea and are being treated with positive airway pressure. This phase 3 study compares NNC0487-0111 to a placebo, which contains no active medicine, to see how well the treatment helps with weight loss and improvement in sleep apnoea symptoms. Participants will receive one of two dose levels of NNC0487-0111 or a matching placebo as weekly injections under the skin. These injections are given alongside a reduced-calorie diet and increased physical activity. The treatment is administered using pre-filled pen injectors to the thigh, abdomen, or upper arm, and the study lasts for 80 weeks. Throughout the trial, participants will be monitored regularly to assess changes in body weight, sleep apnoea severity measured by the apnoea-hypopnoea index AHI, and other health measures such as waist and neck circumference, blood pressure, cholesterol, blood sugar, and sleep quality scores. Safety is tracked by recording any treatment-related adverse events. The study runs until week 80, with follow-up continuing through week 84 to evaluate ongoing safety and effectiveness.

Researchers are evaluating ways to reduce infections after retrograde intrarenal surgery RIRS, a common minimally invasive treatment for kidney stones up to 20 mm. This trial examines the effects of gentamicin-containing irrigation fluid and a suction-enabled ureteral access sheath on postoperative complications such as fever, systemic inflammatory response syndrome SIRS, and sepsis. The study uses a 2x2 factorial design to assess the independent and combined benefits of these two interventions, which target bacterial contamination and elevated intrarenal pressure, respectively. Participants will undergo RIRS under general anesthesia. The study compares four groups standard saline irrigation with a standard ureteral sheath gentamicin added to irrigation fluid with a standard sheath suction-enabled ureteral sheath with standard irrigation and both gentamicin irrigation and suction sheath together. Gentamicin is locally added to irrigation fluid at a dose of 80 mg per 3 L saline bag, while suction-assisted sheaths aim to improve fluid drainage and reduce pressure during the procedure. Stone fragmentation is performed with a holmiumYAG laser, and a ureteral stent is placed afterward. During the study, participants are monitored for infectious outcomes within 48 hours after surgery, including fever, SIRS, and sepsis. Additional assessments include stone-free rates at 4 weeks and changes in blood and urine tests. The trial collects data on urine and blood cultures, white blood cell counts, and kidney function markers. These measures help determine the effects of the interventions on postoperative infection risks and surgical success over the course of follow-up.

Total knee arthroplasty TKA is performed for severe knee conditions but often causes intense pain after surgery, which can delay movement, extend hospital stays, and lower patient satisfaction. Researchers are studying two combinations of regional nerve blocks to manage this pain better while preserving muscle strength the adductor canal block ACB with IPACK block and ACB with Biceps Femoris Short Head BiFeS block. This study is prospective, randomized, and aims to compare the effectiveness of these two approaches in controlling postoperative pain under spinal anesthesia. Participants will be divided into two groups receiving ultrasound-guided nerve blocks. One group will get ACB combined with IPACK block, while the other will receive ACB combined with BiFeS block, both using specific doses of bupivacaine. All patients will also receive spinal anesthesia during surgery. The study includes standardized postoperative pain management with paracetamol and patient-controlled tramadol, with rescue fentanyl available as needed. Pain scores and opioid use will be tracked at multiple time points during the first 24 hours after surgery. Participants will undergo regular assessments including pain ratings at rest and movement, muscle strength tests, and monitoring of side effects like nausea and vomiting. Researchers will also record recovery quality, vital signs, time to first mobility, and bowel function. The primary outcome is total opioid consumption in the first 24 hours, with additional measures such as time to first mobilization and motor block incidence. The study will last through the immediate postoperative period with careful monitoring and safety criteria to stop participation if severe pain occurs.

Hip fractures are common among older adults and often lead to serious health problems, including increased risk of complications and death. Managing pain effectively soon after surgery is important to help patients move early, reduce lung problems, and improve recovery. This research compares two types of nerve blocks, the suprainguinal fascia iliaca block SIFI and the quadro-iliac plane block QIPB, which are techniques used to reduce pain after hip fracture surgery. The study involves patients undergoing hip fracture surgery who will receive one of two ultrasound-guided nerve blocks before surgery. The SIFI block targets nerves around the hip by injecting local anesthetic near the anterior superior iliac spine, while the QIPB targets a broader area near the L3 vertebra involving several nerve branches. Both procedures use a similar dose of bupivacaine and are performed with sterile techniques. The aim is to compare how well each block controls pain and reduces the need for opioid painkillers after surgery. Participants will be closely monitored for pain levels using a numeric rating scale during the first 24 hours after surgery. Researchers will also track opioid use, mobility, and potential side effects. Assessments include pain ratings and the ability to use pain control devices. The study begins with screening and continues through surgery and recovery, with all procedures done under medical supervision. The total participation time covers the preoperative block and 24 hours post-surgery assessment for pain control effectiveness.

Researchers are comparing two common noninvasive treatments for lateral epicondylitis, also known as tennis elbow, which causes pain and reduced function in the elbow due to tendon degeneration. This study evaluates the effects of extracorporeal shock wave therapy ESWT and low-level laser therapy LLLT on pain, elbow function, quality of life, grip strength, and tendon structure in adults aged 18 to 65 with symptoms lasting at least six weeks. Participants will receive a tennis elbow brace and follow a standardized exercise program. They will be randomly assigned to receive either ESWT once weekly for 3 weeks using a specific protocol or LLLT three times per week for 3 weeks at defined points on the elbow. Both treatments target the lateral epicondyle region over the common extensor tendon. No other physical therapies or treatment changes are allowed during the study. Before and after the 3-week treatment period, participants will be assessed for pain using the Visual Analog Scale, elbow function with the Patient-Rated Tennis Elbow Evaluation, quality of life with the Short Form-36, and grip strength using a hand dynamometer. A blinded specialist will perform ultrasound imaging to measure tendon thickness and assess tendon quality. The study aims to compare clinical and structural results between the two therapies while monitoring participant progress throughout.

This research evaluates different upper extremity aerobic exercise training methods to improve arm function in people with heart failure who have cardiac implantable electronic devices like ICD or CRT. It aims to find the best exercise protocol by comparing high-intensity interval training with moderate-intensity continuous training and lower extremity aerobic training. The study focuses on improving upper extremity functional capacity and overall fitness in this specific group of patients. Participants are randomly assigned to one of three groups high-intensity interval upper extremity exercise, moderate-intensity continuous upper extremity exercise, or lower extremity aerobic exercise. The high-intensity protocol includes warm-up, repeated intervals at 80-90% workload, active rest periods, and cool-down over 20 minutes. The moderate-intensity group exercises continuously at 70-80% workload for 20 minutes. The lower extremity group trains for 40 minutes at 70-80% peak oxygen consumption. During the study, participants maximal and functional arm exercise capacity and cardiorespiratory fitness are measured at the start and after 8 weeks. Additional assessments include muscle strength, daily living activities, and quality of life. The trial monitors progress and effects of the exercise protocols over 8 weeks to understand which training best supports arm function and overall fitness in heart failure patients with implantable devices.

Parents of children with special needs often face high stress levels and challenges in managing their emotions, which can affect both their well-being and their relationships with their children. This randomized controlled trial aims to evaluate the effects of a Comfort Theory-based yoga and values clarification intervention on emotional regulation, comfort, and perceived stress levels in these parents. The study is designed to provide evidence on effective nursing interventions to support caregiver psychological health. Participants will be randomly assigned to one of three groups a yoga intervention group, a values clarification group, or a control group with no intervention. The yoga program consists of structured sessions over 8 weeks involving breathing exercises, physical postures, and relaxation techniques to promote emotional regulation and comfort. The values clarification group will engage in activities to identify personal values, improve emotional awareness, and develop coping skills over the same 8-week period. The control group will not receive any intervention during the study. Participants will complete assessments using the Emotion Regulation Scale, Perceived Stress Scale, and General Comfort Questionnaire at baseline, immediately after the 8-week intervention, and at 1-month and 3-month follow-ups. Researchers will monitor changes in emotional regulation, stress, and comfort levels to evaluate the interventions impact. The total duration of participation includes the intervention period plus follow-up assessments to track lasting effects.