Duzce

This research aims to explore how vitamin D deficiency might affect the frequency and severity of low blood pressure caused by spinal anesthesia during cesarean sections in pregnant women. Spinal anesthesia often leads to significant drops in blood pressure, which can pose risks to both mother and baby. Since vitamin D deficiency is common in pregnancy and may influence blood vessel function and stability, understanding this relationship could improve care during cesarean deliveries. Pregnant women scheduled for elective cesarean sections under spinal anesthesia will have their vitamin D levels measured before surgery. Throughout the operation, their blood pressure and heart rate will be continuously monitored for 30 minutes after spinal anesthesia. Researchers will track episodes of hypotension, defined as a 20% or more drop in systolic blood pressure or readings below 90 mmHg. Participants will be grouped based on their vitamin D status as either deficient or sufficient. Participants will be closely observed during surgery with continuous monitoring of vital signs and recording of any medications or fluids given to manage blood pressure. The study will measure how often hypotension occurs and how much medication is needed to treat it. These findings aim to improve understanding of how vitamin D levels affect blood pressure control during cesarean sections. The study is expected to run until the end of 2025 and includes women aged 18 to 40 years undergoing elective procedures.

Researchers are studying patients with latent Hepatitis B virus HBV infection who require immunosuppressive therapy and antiviral prophylaxis. The study aims to monitor long-term effects on bone, kidney, and metabolic health associated with oral antiviral treatment and other health factors. This multicenter, prospective research hopes to improve understanding of the safety and management of HBV prophylaxis in immunocompromised patients. Participants will include those starting HBV antiviral prophylaxis under immunosuppressive treatment. The study will follow patients for four years, collecting data at multiple time points including baseline, and weeks 6, 12, 24, and 48. Assessments will include bone density scans, kidney function tests, metabolic profiles, and liver evaluations to analyze organ health during antiviral use. Throughout the study, patients will attend scheduled visits for comprehensive monitoring of their bone, kidney, metabolic, and liver status. Data will be recorded in a centralized system to ensure accurate tracking. The main outcomes measured are kidney function, bone health, and metabolic status over the first year, with additional liver assessments. Participation includes regular testing and follow-up to understand long-term effects of antiviral therapy.

This observational study focuses on elderly patients aged 65 and older who have femur fractures combined with a high frailty index. Researchers want to understand if giving preoperative oral nutrition support can improve clinical outcomes such as hemodynamic stability during and after surgery, reduce postoperative complications, mortality, and shorten hospital stays in this vulnerable population. Participants are observed in two groups based on routine clinical practice one group receives standard preoperative oral nutritional supplements recommended by the hospital nutrition clinic while staying in the orthopedic ward, and the other group continues their usual diet without additional nutritional support. No interventions are assigned by the investigators. Hemodynamic parameters and other health measurements are recorded during surgery and postoperative care. Throughout the study, participants will have anthropometric measurements like arm and waist circumference, laboratory values, and outcomes such as morbidity, mortality, ICU stay length, and total hospital stay tracked. Follow-ups occur at 30 and 90 days after surgery to monitor complications and survival. The study aims to inform future nutritional strategies for frail elderly patients undergoing surgery for femur fractures.