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Found 7 Actively Recruiting clinical trials

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Actively Recruiting

Healthy Volunteer

Researchers are comparing two methods of crown lengthening, a dental procedure to reshape gums and sometimes bone to expose more of a tooths structure. This procedure is performed for both functional reasons, like preparing a tooth for a crown, and aesthetic reasons, such as improving the smiles appearance. The study evaluates traditional surgical crown lengthening against a less invasive laser-assisted method using the erbiumYAG laser, focusing on periodontal health outcomes. The study involves two groups one receiving the traditional surgical crown lengthening, which includes incisions, flap elevation, bone reshaping, and suturing and the other treated with the erbiumYAG laser that reshapes soft and hard tissues using specific laser settings and tips without flap surgery. The laser group uses a flapless technique, aiming to reduce discomfort and promote faster healing. Both procedures are performed following standard clinical guidelines. Participants will be assessed for postoperative pain shortly after treatment and at three days, as well as periodontal health measures like probing depth at baseline, three months, and six months. Patient satisfaction with the procedure is also measured over time. The study includes follow-up visits for up to six months to monitor outcomes and healing. Overall participation lasts from screening through the follow-up period, with detailed evaluations of pain, tissue healing, and patient experience.

Age: 20Years - 70YearsAll GendersPhase Not Applicable
1 location
C

Actively Recruiting

Researchers are evaluating different treatment approaches for patients with frozen shoulder, aiming to improve shoulder function, reduce pain, and increase range of motion. The study compares the effects of Shoulder Symptom Modification Procedure SSMP, Mobilization With Movement MWM, and sham mobilization to determine which provides the most effective results. Participants are randomly assigned to one of three groups one receiving SSMP followed by a series of exercises including isometric, eccentric, heavy slow resistance, and functional programs another receiving MWM followed by the same exercise progression and a third receiving sham mobilization as a placebo followed by the same exercise routine. The study timeline includes evaluation up to 8 weeks with various outcome measures. During the study, participants will be assessed using the Shoulder Pain and Disability Index and Numeric Pain Rating Scale at enrollment and weeks 4, 6, and 8. Additional measurements include range of motion at these weeks and a Patients Global Impression of Change scale at enrollment and week 8. The study involves scheduled exercises and monitoring to track progress and response to the interventions.

Age: 40Years - 65YearsAll GendersPhase Not Applicable
1 location
E

Actively Recruiting

Stroke is a leading cause of death and long-term disability worldwide, often resulting in spasticity, which is increased muscle tightness and impaired movement. This condition affects most stroke survivors, particularly impacting the upper limb and complicating recovery of arm and hand functions needed for daily activities. Traditional treatments like oral medications and botulinum toxin injections have limitations, prompting research into new non-invasive methods such as Extracorporeal Shock Wave Therapy ESWT. The study evaluates the use of ESWT, which applies acoustic waves to spastic upper limb muscles to reduce muscle overactivity and support neuroplasticity. Participants are randomly assigned to receive either real ESWT combined with conventional physiotherapy or a sham ESWT with the same physiotherapy program. The ESWT protocol targets specific muscles with defined shock numbers, energy, and frequency, aiming to improve upper limb function in stroke survivors. Participants will be assessed at baseline, after 6 weeks of intervention, and at a 10-week follow-up. Evaluations include upper limb function tests, electrical muscle activation, and muscle force capacity. The study includes structured rehabilitation exercises such as stretching, mobility, strengthening, and functional training. These assessments and therapies help measure the impact of ESWT on muscle spasticity and arm function, with safety and long-term effects monitored throughout the study period.

Age: 18Years - 65YearsAll GendersPhase Not Applicable
1 location
C

Actively Recruiting

Healthy Volunteer

This research investigates different bone graft materials used in lateral sinus floor elevation to support dental implants in adults with insufficient bone height in the posterior maxilla. The study compares the use of deproteinized bovine bone mineral DBBM alone versus a combination of DBBM with leukocyte- and platelet-rich fibrin L-PRF to evaluate their effects on bone regeneration and implant site development. The rationale is that L-PRF contains biological mediators that may enhance healing and bone formation, potentially improving outcomes compared to xenograft alone. Participants will undergo lateral sinus lift surgery following local anesthesia. One group will receive DBBM alone placed beneath the elevated sinus membrane and covered with a resorbable collagen membrane over the lateral window. The other group will receive a graft made by mixing L-PRF membranes with DBBM particles, forming an L-PRF block, placed under the sinus membrane, with additional L-PRF membranes covering the lateral window. Blood will be collected and processed to prepare L-PRF membranes immediately before surgery. During the study, participants bone gain and bone formation will be assessed at six months after surgery using vertical bone gain measurements and histomorphometric analysis. Researchers will also monitor postoperative pain, morbidity, and surgical complications shortly after surgery. The overall treatment and follow-up last at least six months, with safety and healing carefully observed to evaluate the effectiveness of the graft materials in supporting implant placement.

Age: 21Years - 70YearsAll GendersPhase Not Applicable
1 location
C

Actively Recruiting

Healthy Volunteer

Researchers are studying the effectiveness of multilayered platelet-rich fibrin PRF membrane compared to the gold standard connective tissue graft CTG for improving gum tissue around dental implants in the front of the mouth. The study focuses on achieving a good biological seal to protect implants and support esthetic outcomes, particularly in the anterior region where appearance is important. This research aims to explore whether PRF membrane offers benefits similar to CTG without added patient morbidity during the healing period after the second stage of implant surgery. Participants will receive either a dental implant combined with a multilayered PRF membrane or a dental implant with a connective tissue graft. Both groups will have implants placed at the subcrestal level following standard procedures, including local anesthesia, incision, flap reflection, and osteotomy. About four months after implant placement, a healing abutment will be positioned with sutures to secure the tissues. The PRF membrane is stabilized using the healing abutment to prolong exposure to growth factors, and the study compares these two approaches during the healing phase of the second-stage surgery. Participants will be assessed for peri-implant soft tissue thickness at 6 weeks and at 3 and 6 months after treatment. Other measurements include the width of keratinized tissue around the implants at baseline, 3, and 6 months, marginal bone loss at 6 months, and patient satisfaction using a visual scale at baseline, 2 weeks, and 6 months. The study involves regular evaluations of tissue healing and implant support over a 6-month period, with safety and effectiveness monitored throughout the process.

Age: 20Years - 70YearsAll GendersPhase Not Applicable
1 location
C

Actively Recruiting

Researchers are evaluating the effectiveness of immersive virtual reality compared to non-immersive virtual reality, both combined with conventional therapy, in improving upper limb function in people with subacute hemiplegia following a stroke. This randomized controlled trial includes male and female participants aged 28 to 55 years who meet specific motor and cognitive criteria. The study aims to better understand how different virtual reality therapies can enhance motor recovery in stroke patients. Participants are randomly assigned to one of two groups. Group 1 receives 15 minutes of conventional therapy followed by 45 minutes of immersive virtual reality therapy using the Oculus Quest 3 headset, which offers advanced motion tracking for task-specific exercises. Group 2 receives 15 minutes of conventional therapy followed by 45 minutes of non-immersive virtual reality therapy using devices like the Neofect Smartboard and Tyromotion Myro, which use gamified and sensor-based exercises to improve upper limb mobility and fine motor skills. Throughout the study, researchers assess participants with tests such as the Fugl-Meyer Assessment for the upper extremity and the Graded Wolf Motor Function Test to measure motor improvements. Quality of life is also evaluated using the Stroke Specific Quality of Life Scale. Assessments occur at the start and again six weeks after the intervention. The study is single-blinded, with the assessor unaware of group assignments, and participants engage in therapy sessions involving stretching, strengthening, and virtual reality training during the study period.

Age: 28Years - 55YearsAll GendersPhase Not Applicable
1 location
C

Actively Recruiting

Healthy Volunteer

This research aims to compare the effects of preoperative use of alpha-chemo-trypsin, ibuprofen, and acetaminophen in controlling pain after root canal treatment in patients with symptomatic irreversible pulpitis. The study seeks to understand which premedication works best to manage post-endodontic pain. It is a randomized, triple-blinded clinical trial sponsored by Gulf Medical University and focuses on adults aged 20 to 50 years. Participants will receive one of the study medicationsalpha-chemo-trypsin, ibuprofen, acetaminophen, or a placeboone hour before undergoing root canal treatment. The procedure includes local anesthesia, access cavity preparation, cleaning and shaping of the root canal, obturation, and final restoration following a standardized protocol. During the study, patients will report their pain levels using a visual analogue scale at 6, 12, 24, and 48 hours after the treatment. Researchers will record preoperative pain scores and monitor post-endodontic pain intensity at these intervals to evaluate the effectiveness of each premedication. The total study duration for each participant corresponds to the follow-up pain assessments within two days after treatment.

Age: 20Years - 50YearsAll GendersPhase 3
1 location