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Found 6 Actively Recruiting clinical trials
Actively Recruiting
This research aims to evaluate different treatment methods for patients with frozen shoulder, focusing on improving shoulder function, reducing pain, and increasing range of motion. The study compares the effects of three interventions: Shoulder Symptom Modification Procedure (SSMP), Mobilization With Movement (MWM), and sham mobilization to determine which provides the most effective results. Participants are assigned to one of three treatment groups. The first group receives SSMP in the initial phase, followed by isometric exercises, eccentric exercises, heavy slow resistance training, and a functional program. The second group undergoes MWM first, then the same sequence of exercises and functional training. The third group receives sham mobilization before progressing through the same exercise and functional phases. Throughout the study, participants will be assessed using the Shoulder Pain And Disability Index and Numeric Pain Rating Scale at multiple time points up to 8 weeks. These evaluations help track changes in pain, disability, and shoulder function. The total participant age range is 40 to 65 years, and the study includes monitoring to understand which intervention is most beneficial for managing frozen shoulder symptoms.
Actively Recruiting
Stroke is a leading cause of death and long-term disability worldwide, frequently resulting in spasticity characterized by increased muscle tone and impaired movement. This condition commonly affects the upper limbs of stroke survivors, limiting their ability to perform basic daily activities like dressing and feeding. Traditional treatments such as oral medications and botulinum toxin injections provide some relief but have limitations, prompting investigation into new, non-invasive therapies like extracorporeal shock wave therapy (ESWT). This research evaluates ESWT, which uses controlled acoustic waves to target specific upper limb muscles affected by spasticity, including the biceps brachii, flexor carpi radialis, pronator teres, and wrist and finger flexors. The therapy involves delivering 2000 shocks per muscle per session at defined energy and frequency settings. Alongside ESWT, participants also receive stretching, mobility, strengthening, and functional task-oriented training to enhance upper limb function. The study aims to determine optimal treatment parameters and the impact of ESWT combined with rehabilitation on reducing spasticity and improving arm and hand movement. Participants will be assessed at baseline, after six weeks of intervention, and one month later to measure upper limb function using standardized tests. Throughout the study, researchers will monitor muscle tone, movement ability, and any side effects. The trial includes detailed evaluations of muscle response and functional gains to better understand ESWT’s role in stroke rehabilitation. The total participation period spans at least ten weeks, including treatment and follow-up phases.
Actively Recruiting
Researchers are investigating the effectiveness of immersive virtual reality compared to non-immersive virtual reality, both combined with conventional therapy, to improve upper limb function in adults with subacute hemiplegia following stroke. This randomized controlled trial includes male and female participants aged 28 to 55 years who meet specific motor function and cognitive criteria. The study aims to enhance upper limb motor recovery using advanced virtual reality technologies alongside traditional rehabilitation exercises. Participants are randomly assigned to one of two groups: Group 1 receives conventional therapy combined with immersive virtual reality using the Oculus Quest 3 headset, which offers precise motion tracking and task-specific exercises. Group 2 receives conventional therapy combined with non-immersive virtual reality using devices like the Neofect Smartboard and Tyromotion Myro, which provide interactive, gamified exercises and sensor-based feedback to improve fine motor skills. Each therapy session starts with 15 minutes of stretching and strengthening exercises, followed by 45 minutes of virtual reality training. Participants undergo baseline assessments and follow-up evaluations six weeks after the intervention. Outcome measures include the Fugl-Meyer Assessment for Upper Extremity and the Graded Wolf Motor Function Test to track changes in upper limb function. Additionally, the Stroke Specific Quality of Life Scale questionnaire is used as a secondary outcome measure. The assessor conducting the evaluations is blinded to group assignments to ensure unbiased results.
Actively Recruiting
Healthy Volunteer
Researchers are evaluating how well preoperative doses of alpha-chemo-trypsin, ibuprofen, and acetaminophen manage pain after root canal treatment in patients with symptomatic irreversible pulpitis. This Phase 3 trial aims to compare these medications to understand which best reduces post-endodontic pain. The study focuses on patients diagnosed with symptomatic irreversible pulpitis in mandibular molars who need root canal treatment. Participants will receive one of the premedications one hour before undergoing a standardized root canal procedure. This includes anesthesia with lidocaine, isolation with a rubber dam, cavity preparation, cleaning and shaping of the root canal, obturation, and final restoration. The study is triple-blinded, meaning neither the patients, clinicians, nor evaluators know which medication is given. Pain levels will be measured using a visual analogue scale at 6, 12, 24, and 48 hours after the procedure to assess how each premedication affects post-endodontic pain. The study also involves recording medical history, vitality testing, and preoperative pain scores. Participants will provide informed consent and be monitored throughout the treatment and follow-up period.
Actively Recruiting
Healthy Volunteer
This research investigates the effectiveness of the Hunova Robotic System compared to traditional Balance and Mobility Exercise programs in improving balance, postural stability, functional gait, and fall efficacy in older adults aged 60 to 85. Aging often leads to reduced motor function, balance, and proprioception, increasing fall risk and affecting quality of life. Traditional exercise programs like the Otago Exercise Program have limitations due to their generalized approach, prompting the need for more personalized interventions. The study compares two interventions: the Hunova Robotic-Assisted System, which provides individualized, real-time feedback and adjusts to patients' specific needs, and traditional Balance and Mobility Exercises derived from the Otago Exercise Programme. These interventions aim to enhance balance and mobility through tailored or generalized exercise protocols, respectively. Participants will be assessed at the start and after 12 weeks using Hunova Evaluation Tools to measure improvements. The study will track balance, postural stability, functional gait, and fall efficacy, with evaluations including functional assessments and monitoring adherence. The total study duration and detailed participant involvement include baseline and follow-up assessments to analyze the effectiveness of these interventions in older adults.
Actively Recruiting
Researchers are evaluating how AI-based educational videos can improve oral health outcomes for older adults who wear removable dentures. This study uses a randomized controlled trial to compare AI-based video education with traditional verbal instructions provided by a prosthodontic team. The goal is to see which method better enhances denture care knowledge, patient satisfaction, and quality of life related to oral health. Participants are divided into two groups. One group watches an approximately 8-minute AI-guided video that provides clear, step-by-step demonstrations on denture care with engaging narration. The other group receives standard oral health education through verbal and chairside instructions from healthcare professionals covering denture hygiene, storage, and mucosal care. This design allows direct comparison of these different educational approaches. During the study, participants will have their oral health-related quality of life measured at the start, immediately after the education, and then at 1, 2, and 3 months follow-up using a standardized questionnaire. Researchers will assess how well participants learn denture care, their satisfaction, and any improvements in quality of life. This monitoring helps understand the lasting impact of each educational method over several months.