Cold Spring Harbor

Researchers are studying blood-based biomarkers to develop a minimally invasive test for early detection of pancreatic cancer and to monitor treatment response. The study focuses on pancreatic ductal adenocarcinoma and other pancreatic diseases, aiming to improve diagnosis at early disease stages. This research assesses changes in biomarkers over a four-year period to evaluate the test's accuracy in identifying early-stage pancreatic cancer. Participants may undergo blood draws, with up to 50ml collected safely depending on their weight and hemoglobin levels. Tumor tissue and cyst fluid samples will be collected through planned biopsies either at the study center or elsewhere. These samples help researchers analyze biomarkers related to pancreatic cancer and other pancreatic conditions. During the study, participants will provide blood and tissue samples and may have biopsies as part of their routine care. Researchers will monitor biomarker changes and compare results to confirm the test's ability to detect early pancreatic cancer. The study involves various participant groups including those with advanced or operable pancreatic cancer, benign pancreatic diseases, pancreatic cysts, and healthy controls. The total follow-up for outcome measurement is four years.

Researchers are creating a registry to learn more about germ cell tumors and other testicular tumors. This study includes people diagnosed with these tumors, their relatives, and unrelated individuals without these tumors. By studying these groups, the research aims to understand why some people develop these tumors while others do not and to improve knowledge about their prevention, diagnosis, treatment, and outcomes. Participants will complete questionnaires and provide a blood or saliva sample for DNA analysis. Approximately 2 to 4 tubes of blood or one tablespoon of saliva will be collected, though those who have already provided a DNA sample for another approved study may not need to give another. The study includes different groups: people with or suspected to have germ cell or testicular tumors, their blood relatives, and unrelated individuals without a history of these tumors. During the study, participants will answer questionnaires and provide DNA samples. The main outcome is to establish a germ cell tumor and testicular tumor registry over five years. This registry will help researchers gather detailed information about these tumors and their genetic factors. Participants will be followed and monitored through the data collected for the duration of the study.