Actively Recruiting
Germ Cell Tumor and Testicular Tumor DNA Registry
Led by Memorial Sloan Kettering Cancer Center · Updated on 2026-02-04
1000
Participants Needed
8
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are creating a registry to better understand germ cell tumors (GCT) and other testicular tumors. This registry includes people diagnosed with these tumors, their relatives, and unrelated individuals without these tumors. The study aims to learn more about how these tumors develop, how to prevent and diagnose them, and the outcomes of different treatments. By including family members and unrelated healthy people, the study hopes to uncover why some people develop these tumors while others do not. Participants are grouped into three categories: those with testicular GCTs or non-GCT testicular tumors (including some female GCT cases), relatives of patients with these tumors, and healthy controls who have no personal or family history of these tumors. Participants provide information through questionnaires and give a blood or saliva sample for DNA analysis. If a DNA sample was already given in another approved study, additional sampling may not be needed. During the study, participants will complete questionnaires and provide biological samples to assist in DNA extraction and analysis. Researchers will collect and store this information to build a comprehensive registry over five years. This registry will help track tumor characteristics, family history, and genetic factors. The study is observational, so participants will not receive treatment as part of the trial but will contribute to knowledge about these tumors. The study is open to adults 18 years and older and includes healthy volunteers as well as affected individuals and their relatives.
CONDITIONS
Brief Title
Germ Cell Tumor and Testicular Tumor DNA Registry
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Must be 18 years of age or older
- Must be able to speak and understand English
- For case cohort: Must have a diagnosis or suspicion of germ cell tumor and/or a testicular mass
- For family member cohort: Must be a blood relative of a person with germ cell tumor or testicular tumor
- For control cohort: Must not have a personal history of cancer except non-melanoma skin cancer
- For control cohort: Must not have a family history of germ cell tumor or testicular tumor
- For control cohort: Must not be a blood relative of controls enrolled in this study
You will not qualify if you...
History of severe allergic reactions to study medication Currently pregnant or breastfeeding Recent participation in another clinical trial within the last 30 days Presence of uncontrolled medical conditions that could affect safety
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Single timepoint
Participants provide a blood or saliva sample for DNA extraction. Some participants may not need to provide an additional sample if they have already contributed one to another approved study.
1 visit (in-person)
Duration - Single timepoint
Participants complete behavioral questionnaires related to the study.
1 visit (in-person) or remote completion
Duration - Up to 5 years
Participants contribute data to the Germ Cell Tumor and Testicular Tumor DNA Registry over time.
Periodic contact for data updates
Trial Site Locations
Total: 8 locations
1
Memorial Sloan Kettering Basking Ridge
Basking Ridge, New Jersey, United States
Actively Recruiting
2
Memorial Sloan Kettering Monmouth
Middletown, New Jersey, United States, 07748
Actively Recruiting
3
Memorial Sloan Kettering Bergen
Montvale, New Jersey, United States, 07645
Actively Recruiting
4
Cold Springs Harbor Laboratory (Specimen Analysis)
Cold Spring Harbor, New York, United States, 11724
Not Yet Recruiting
5
Memorial Sloan Kettering Commack
Commack, New York, United States, 11725
Actively Recruiting
6
Memorial Sloan Kettering Westchester
Harrison, New York, United States, 10604
Actively Recruiting
7
Memorial Sloan Kettering Cancer Center
New York, New York, United States, 10065
Actively Recruiting
8
Memorial Sloan Kettering Nassau
Uniondale, New York, United States, 11553
Not Yet Recruiting
Research Team
D
Darren Feldman, MD
J
Joel Sheinfeld, MD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
3
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