Elmsford

Researchers are evaluating the use of a non-ablative 1470 nm laser for treating androgenetic alopecia and scarring alopecia in this single-center, open-label pilot study. The study aims to enroll up to 10 participants with biopsy-confirmed alopecia who seek improvement in hair loss. The study includes two treatment groups one for androgenetic alopecia and one for scarring alopecia, with five participants in each. Participants will receive up to three treatments using the Sciton HALO 1470nm non-ablative laser. Each treatment targets affected scalp areas and lasts approximately 10 to 15 minutes. Before treatment, a topical anesthetic and antiseptic cleaning are applied, followed by post-treatment care including topical betamethasone dipropionate cream. Treatments follow a set protocol to create controlled zones in the scalp skin to potentially enhance hair growth. Participants will have follow-up visits at months 6, 9, 12, and 15 after their initial treatment. During these visits, standardized photographs and hair density measurements using the Canfield HairMetrix device will be collected and compared to baseline. Participants will also complete questionnaires regarding pain, satisfaction, and self-assessment of hair growth. The study monitors safety and treatment effects over a total period of approximately 15 months.

Researchers are studying the effectiveness and tolerability of a hybrid non-ablativeablative laser called the Sciton Halo for treating acne scars, especially in people with darker skin tones Fitzpatrick IV and V. Acne scarring can negatively impact quality of life and mental health, and current treatments have limited evidence for their benefit. This study focuses on improving acne scars with this newer laser technology that combines two wavelengths for targeted skin treatment. Participants receive treatment with the Sciton Halo hybrid fractional laser in two groups based on skin type. Each group will have 23 participants with either Fitzpatrick skin types IV-V or I-III. At the first visit, participants provide consent, receive education on the procedure and sun care, and are given sunscreen. They may be prescribed hydroquinone or retinol to prevent hyperpigmentation, starting treatment after one month if they choose. Treatment involves up to three laser sessions, with the number depending on improvement. Before and after photos are taken at each session, and participants complete quality of life and satisfaction surveys. During the study, participants will be monitored regularly up to nine months. Assessments include changes in acne scar severity, clinician and patient evaluations of improvement, skin texture, pigmentation, and overall satisfaction. Researchers will also track adherence to skin care, sunscreen use, sun avoidance, side effects, and pain. The study aims to measure both clinical outcomes and patient experiences over time to evaluate the lasers impact on acne scars in skin of color.

Researchers are evaluating the use of a non-ablative 1470 nm laser to treat scarring alopecia in adults. This study aims to determine if the laser effectively treats scarring alopecia and to understand the molecular pathways affected by the laser in hair follicles. The trial includes participants with biopsy-proven or clinically diagnosed scarring alopecia who have not had recent hair loss treatments. Participants will receive three laser treatments spaced one month apart using the non-ablative Sciton HALO laser. Each session lasts about 10 to 15 minutes and involves applying a topical anesthetic and cleaning the scalp before treatment. The laser creates controlled micro-channels in the skin to minimize tissue damage while potentially improving treatment effects. After treatment, participants will follow standard care guidelines. During the study, hair follicle samples will be collected by plucking hairs before the first treatment and one month after the last treatment to analyze gene expression related to inflammation and fibrosis. Participants will attend five follow-up visits over 15 months for clinical assessments, including hair density measurement with a specialized device and photographic evaluations. They will also complete questionnaires, self-assessments, and keep a diary of any side effects. The main outcomes measured include hair density, hair counts, and aesthetic improvement scales over time.