Port Angeles

Researchers are studying the safety and effects of a medicine called Mevrometostat for treating three types of cancer RelapsedRefractory Small Cell Lung Cancer SCLC, Castration Resistant Prostate Cancer CRPC, and Follicular Lymphoma FL. This study is a Phase 1 trial that includes three parts, with Parts 1 and 2 now closed for enrollment. The current enrollment is open for men with CRPC who have previously been treated and whose disease has progressed since their last treatment. The purpose is to evaluate how Mevrometostat works alone or combined with other treatments in these cancers. The study involves giving Mevrometostat by mouth either alone or with other drugs such as Enzalutamide and Itraconazole, depending on the specific part or cohort. Part 3 consists of two substudies a Bioequivalence BE substudy where participants take three single doses of two Mevrometostat formulations over three periods, and a Drug-Drug Interaction DDI substudy with two cohorts receiving Mevrometostat alone or combined with Enzalutamide andor Itraconazole. After these assessment phases, participants enter a maintenance phase where they take Mevrometostat twice daily and Enzalutamide once daily until the cancer no longer responds. During the study, participants will be closely monitored for safety, including adverse events, laboratory tests, and vital signs over about two years. The researchers will also assess how well the drug works by measuring cancer response and progression-free survival. Pharmacokinetic studies will track how the drug behaves in the body. Patient experiences and symptoms will be evaluated through questionnaires. Overall, participants can expect regular visits to receive the study drugs, undergo testing, and provide feedback throughout their participation, which may last until disease progression or study completion.

Researchers are evaluating the impact of real-time audio-video telemedicine consultations with a neonatologist, called teleneonatology, on early health outcomes of at-risk newborns delivered in community hospitals. This study uses a stepped wedge cluster randomized design to compare early mortality, morbidity, and delivery room care between neonates receiving teleneonatology support and those receiving usual care. The trial is led by Mayo Clinic and focuses on newborns facing significant resuscitation needs shortly after birth. The study involves two groups one where at-risk neonates receive care from the community hospital team with telemedicine support from a neonatologist located at a regional neonatal intensive care unit, and a control group where neonates receive the hospitals usual care without telemedicine consultation. The telemedicine connection allows real-time, two-way audio and video communication during advanced neonatal resuscitations. The study includes neonates born preterm under 32 weeks or requiring advanced resuscitation interventions such as prolonged positive pressure ventilation, alternative airway placement, or chest compressions. Participants include clinicians attending newborn resuscitations and eligible neonates born at participating community hospitals. Researchers will monitor outcomes including mortality within 7 days, early neonatal morbidity, combined mortality and morbidity, and the highest level of resuscitation given in the delivery room within the first hour. The study tracks these outcomes to assess the effect of teleneonatology on newborn health during this critical early period. The total study duration extends through May 2029.