Study of Brain Radiation Effects on Thinking and Brain Imaging in Adults with Primary Brain Tumors

What this Trial Is About

Researchers are conducting a prospective study to examine how fractionated radiation therapy affects brain tissue and cognition in patients with primary brain tumors. The goal is to better understand cognitive changes caused by radiation to non-targeted brain areas and to identify brain regions sensitive to radiation damage, aiming to improve future cognitive-sparing radiotherapy approaches. This study uses advanced neuroimaging and neurocognitive testing to track changes over time. Participants are primary brain tumor patients scheduled to receive fractionated partial brain radiation therapy. They will undergo multiple brain MRI scans, including volumetric and diffusion imaging, along with neurocognitive tests before treatment and at 3, 6, and 12 months after treatment. Clinical information such as age, tumor details, medication use, and treatment history will also be collected. During the study, participants will be assessed at baseline and at three follow-up times to monitor brain imaging biomarkers and various cognitive functions such as memory, attention, language, and motor skills. Quality of life will be tracked up to five years after radiation therapy. The study aims to correlate imaging changes with cognitive outcomes to inform better treatment planning and minimize cognitive side effects. Participation may last several years due to long-term follow-up assessments.

Longitudinal Prospective Study of Neurocognition & Neuroimaging in Primary BT Patients