Actively Recruiting
MAGNETIC RESONANCE SPECTROSCOPY BIOMARKERS IN TYPE 3 GAUCHER DISEASE (GD3)
Led by University of Minnesota · Updated on 2026-01-08
5
Participants Needed
1
Research Sites
186 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Recent studies have has shown that magnetic resonance spectroscopy (MRS) can provide validated neuronal markers in patients with Type 1 GD (GD1) who are on stable therapy. However, alterations in neurometabolites in adult patients with GD3, who have established neurological involvement, are not well understood. The goal of this study is to characterize neurometabolite profiles in adult patients with GD3 using MRS to identify novel biomarkers that can demonstrate treatment response. Additionally, a secondary aim is to evaluate relationships between neurometabolites and disease parameters, such as genotype, enzyme levels and Gaucher disease (GD) biomarkers.
CONDITIONS
Official Title
MAGNETIC RESONANCE SPECTROSCOPY BIOMARKERS IN TYPE 3 GAUCHER DISEASE (GD3)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Must be 18 years or older
- Must understand and cooperate with study requirements
- Must provide written informed consent
- Must have Type 3 Gaucher Disease and be medically stable for participation as judged by the investigator
You will not qualify if you...
- Medically unstable conditions
- Other diseases or circumstances that could affect safety, study compliance, or data integrity
- Women who are pregnant, lactating, or of child-bearing age not using contraception
- Participation in another interventional study
- Unable or unwilling to have blood drawn
- Unable to undergo MRI scanning due to inability to stay still, claustrophobia, metal implants, pacemakers, or weight over 300 lbs
- Unable to follow study protocol for any reason
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of Minnesota
Minneapolis, Minnesota, United States, 55455
Actively Recruiting
Research Team
R
Reena Kartha, PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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