Actively Recruiting
Comparison of Mean Arterial Pressure-Based and Cardiac Index-Based Intraoperative Hemodynamic Management on Postoperative Kidney Function in Colorectal Surgery
Led by Ankara Etlik City Hospital · Updated on 2026-06-03
60
Participants Needed
1
Research Sites
2 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating two different methods of managing blood flow and pressure during colorectal surgery to see how they affect kidney function after the operation. This trial compares mean arterial pressure-guided management with cardiac index-guided management in adult patients undergoing colorectal surgery. The study aims to understand which approach better preserves kidney function early after surgery, considering that colorectal surgery involves risks like blood loss and unstable circulation that can harm the kidneys. Participants will be randomly assigned to receive either mean arterial pressure-guided or cardiac index-guided hemodynamic management during their surgery. Both groups will have fluid therapy, vasopressors, and other standard treatments adjusted based on their assigned targets. In the cardiac index group, inotropes may also be used according to the patient's circulatory status. Standard anesthetic care and monitoring will be applied according to hospital practice throughout the procedure. During the study, researchers will measure changes in serum creatinine from before surgery to 72 hours afterwards as the primary outcome. They will also track intraoperative urine output, fluid use, postoperative kidney function at various time points, length of hospital and ICU stay, and 30-day mortality. Participants will be monitored closely during and after surgery, with data collected up to 72 hours postoperatively to assess kidney function and overall recovery.
CONDITIONS
Brief Title
MAP- Versus Cardiac Index-Guided Hemodynamic Management in Colorectal Surgery
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients aged 18 to 80 years
- Patients with American Society of Anesthesiologists physical status II-III
- Patients with estimated glomerular filtration rate 60 mL/min/1.73 m8
- Patients scheduled for colorectal surgery
- Patients who provide written informed consent
You will not qualify if you...
- Patients younger than 18 years or older than 80 years
- Patients with estimated glomerular filtration rate <60 mL/min/1.73 m8
- Patients with American Society of Anesthesiologists physical status other than II-III
- Patients who refuse to participate in the study
- Patients who withdraw consent at any stage of the study
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Duration of the surgery
Participants undergo intraoperative hemodynamic management during colorectal surgery. Management is guided by either mean arterial pressure or cardiac index targets, with fluid therapy, vasopressor, and inotrope use adjusted according to institutional clinical practice.
1 surgery visit (in-person)
Duration - 72 hours after surgery
Participants are monitored for kidney function and other outcomes up to 72 hours after surgery.
Visits at 0-6 hours, 24 hours, 48 hours, and 72 hours postoperatively (in-person)
Trial Site Locations
Total: 1 location
1
Ankara Etlik City Hospital
Ankara, Yenimahalle\Ankara, Turkey (Türkiye), 06170
Actively Recruiting
Research Team
İ
İbrahim MD Topcu
M
Musa Ass. Prof Zengin
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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