Metabolomic Study of Severe Traumatic Brain Injury Compared to Orthopedic Trauma Observational Research in Adults Aged 18 to 65

What this Trial Is About

Traumatic Brain Injury TBI is a major cause of death and disability worldwide, especially among young people. Researchers are examining differences in metabolite levels between patients with severe TBI and those with orthopedic trauma without brain injury. This study aims to better understand the metabolic changes in TBI that may help predict outcomes and guide treatment. The study involves two groups patients aged 18 to 65 with severe TBI diagnosed clinically or by NICE criteria including imaging, and patients aged 18 to 65 with traumatic injuries but no brain injury. Researchers will analyze blood samples to profile metabolites, focusing on brain-specific small molecules that may indicate blood-brain barrier dysfunction. Participants will provide samples on the first day for metabolomic analysis. Researchers will measure changes in metabolite levels to explore the metabolic effects of TBI. The study is observational, with no treatments assigned. Participation includes monitoring and data collection to understand metabolic patterns related to brain injury.

Metabolomic Profiling of Patients With Traumatic Brain Injury