Using metabolomics to predict severe traumatic brain injury outcome (GOSE) at 3 and 12 months.
Mohammad M Banoei, Chel Hee Lee, James Hutchison...
https://pubmed.ncbi.nlm.nih.gov/37481590Actively Recruiting
Age: 18Years - 65Years
All Genders
ID07292766
Metabolomic Profiling of Patients With Traumatic Brain Injury
Led by Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital · Updated on 2025-12-18
60
Participants Needed
1
Research Sites
8 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Traumatic Brain Injury (TBI) is a major cause of death and disability worldwide, especially among young people. Researchers are examining differences in metabolite levels between patients with severe TBI and those with orthopedic trauma without brain injury. This study aims to better understand the metabolic changes in TBI that may help predict outcomes and guide treatment. The study involves two groups: patients aged 18 to 65 with severe TBI diagnosed clinically or by NICE criteria including imaging, and patients aged 18 to 65 with traumatic injuries but no brain injury. Researchers will analyze blood samples to profile metabolites, focusing on brain-specific small molecules that may indicate blood-brain barrier dysfunction. Participants will provide samples on the first day for metabolomic analysis. Researchers will measure changes in metabolite levels to explore the metabolic effects of TBI. The study is observational, with no treatments assigned. Participation includes monitoring and data collection to understand metabolic patterns related to brain injury.
CONDITIONS
Brief Title
Metabolomic Profiling of Patients With Traumatic Brain Injury
Who Can Participate
Age: 18Years - 65Years
All Genders
Eligibility Criteria
You may qualify if you...
- Ages 18-65
- Patients diagnosed with severe TBI clinically or according to National Institute for Health and Care Excellence (NICE) criteria including post-traumatic imaging
- Patients with non-TBI orthopedic or multitrauma
You will not qualify if you...
- Presence of brain pathology in the pre-trauma period
- Patient with chronic subdural hematoma
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Diagnostic Evaluation
Duration - 1 day
Participants undergo metabolomic analysis to assess metabolic changes related to traumatic brain injury or other trauma.
1 visit (in-person)
Long-term Monitoring
Duration - Up to 1 year
Participants are observed over time to understand metabolic changes and their implications after injury.
Trial Site Locations
Total: 1 location
1
Aksaray University
Aksaray, Ankara, Turkey (Türkiye), 06810
Actively Recruiting
Loading map...
Research Team
H
Hazal Ekin AYTUĞ, Consultant anesthesiologist
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
Similar Trials
Frequently Asked Questions
Have more questions? Get in touch with our team for quick support
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here
Published Research Related To This Trial
FOXO1 reshapes neutrophils to aggravate acute brain damage and promote late depression after traumatic brain injury.
Mi Zhou, Yang-Wu-Yue Liu, Yu-Hang He...
https://pubmed.ncbi.nlm.nih.gov/38556884Metabolomics in severe traumatic brain injury: a scoping review.
Riley Page Fedoruk, Chel Hee Lee, Mohammad Mehdi Banoei...
https://pubmed.ncbi.nlm.nih.gov/37845610