Actively Recruiting
Mild TBI Assessment & Rehabilitation
Led by VA Office of Research and Development · Updated on 2026-05-06
65
Participants Needed
2
Research Sites
526 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
One of the most pressing concerns within the VA currently is the provision of interventions that address the cognitive as well as emotional problems faced by Veterans with mild TBI and comorbid conditions. When completed, these studies will inform us whether training core attentional self-regulatory control functions via personally-relevant activities will be effective in improving daily life for Veterans with mild TBI and comorbid conditions. The study design will provide a test not only of potential benefits for real life functioning, but also determine to what extent these benefits are related to actual changes in cognitive/behavioral performance and brain networks corresponding to these functions. This project will provide a foundation for future studies to investigate the neural mechanisms that support improvements of cognition and behavior in mTBI.
CONDITIONS
Official Title
Mild TBI Assessment & Rehabilitation
Who Can Participate
Eligibility Criteria
You may qualify if you...
- For Veterans with mild TBI: age 18 or older
- History of mild TBI confirmed by medical records and assessment
- Chronic stable recovery phase more than 6 months after last injury
- Residual moderate or severe cognitive difficulties affecting daily function
- Willing and able to participate in training and assessments
- Stable on psychoactive medications for more than 30 days, if applicable
- For healthy Veterans without TBI: age 18 or older
- No history of any mild to severe TBI
- Willing and able to participate in assessments
- Stable on psychoactive medications for more than 30 days, if applicable
You will not qualify if you...
- History of moderate or severe TBI for Veterans with mild TBI
- Unstable medical, neurological, or psychiatric conditions preventing participation
- Severe cognitive dysfunction or contraindications to MRI
- Ongoing illicit drug or alcohol abuse (AUDIT score >8)
- Psychosis
- Severe depression, anxiety, or PTSD that prevents research participation
- Poor English comprehension
- For healthy Veterans without TBI: any history of mild, moderate, or severe TBI
- Other unstable medical, neurological, or psychiatric conditions preventing participation
- Ongoing illicit drug or alcohol abuse (AUDIT score >8)
- Psychosis
- Severe depression, anxiety, or PTSD that prevents research participation
- Poor English comprehension
AI-Screening
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Trial Site Locations
Total: 2 locations
1
San Francisco VA Medical Center, San Francisco, CA
San Francisco, California, United States, 94121-1563
Completed
2
University of California, San Francisco
San Francisco, California, United States, 94158
Actively Recruiting
Research Team
P
Pratik Mukherjee, MD PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
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