Actively Recruiting
Molecular Imaging of Active Venous Thrombus With Positron Emission Tomography (PET)
Led by University Hospital, Brest · Updated on 2026-06-08
10
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Venous thromboembolism (VTE), which includes deep vein thrombosis (DVT) and pulmonary embolism (PE), is a common and serious cardiovascular condition. Accurate diagnosis of VTE is crucial to determine who needs anticoagulant therapy and to avoid unnecessary treatment. This research aims to improve VTE diagnosis by developing a new imaging biomarker that can directly detect active venous thrombus using positron emission tomography (PET), which offers higher sensitivity and resolution than traditional methods. Participants will undergo a procedure involving additional blood sampling after giving consent, where two tubes of venous blood will be collected to create an in vitro thrombus. This blood sample will be used to evaluate the binding affinity and specificity of a new radiolabeled antibody tracer designed to detect fresh blood clots. The study focuses on testing this tracer's performance outside the body, without involving treatment or intervention beyond sample collection. During the study, researchers will monitor the interaction between the tracer and the blood clots formed in the lab to optimize antibody concentration for best imaging quality. The primary measurement is the binding efficiency of the tracer to fresh thrombi. Participants will be closely observed during the sample collection process, and no long-term follow-up or treatment is involved. The study provides an opportunity for volunteers to contribute to advancing imaging techniques for better VTE diagnosis without impacting their usual medical care.
CONDITIONS
Brief Title
Molecular Imaging of Active Venous Thrombus With Positron Emission Tomography (PET)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged 18 years or older
- Voluntary blood donors
- No known blood clotting disorders such as thrombophilia
- No active cancer
- No chronic medical conditions
- Not currently taking any treatment affecting blood clotting
You will not qualify if you...
- Under 18 years of age
- Known chronic medical conditions
- Long-term use of anti-platelet or anticoagulant medications
- Refusal to participate
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 1 day
Participants provide venous blood samples for in vitro thrombus formation studies.
1 visit (in-person)
Trial Site Locations
Total: 1 location
1
Etablissement francais du sang
Brest, France, 29200
Actively Recruiting
Research Team
P
Philippe ROBIN
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
BASIC_SCIENCE
Number of Arms
1
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