Using PET Molecular Imaging to Detect Active Blood Clots in Adults Studying a New Biomarker for Diagnosing Venous Thromboembolism

What this Trial Is About

Venous thromboembolism VTE, which includes deep vein thrombosis DVT and pulmonary embolism PE, is a common and serious cardiovascular condition. Accurate diagnosis of VTE is crucial to determine who needs anticoagulant therapy and to avoid unnecessary treatment. This research aims to improve VTE diagnosis by developing a new imaging biomarker that can directly detect active venous thrombus using positron emission tomography PET, which offers higher sensitivity and resolution than traditional methods. Participants will undergo a procedure involving additional blood sampling after giving consent, where two tubes of venous blood will be collected to create an in vitro thrombus. This blood sample will be used to evaluate the binding affinity and specificity of a new radiolabeled antibody tracer designed to detect fresh blood clots. The study focuses on testing this tracers performance outside the body, without involving treatment or intervention beyond sample collection. During the study, researchers will monitor the interaction between the tracer and the blood clots formed in the lab to optimize antibody concentration for best imaging quality. The primary measurement is the binding efficiency of the tracer to fresh thrombi. Participants will be closely observed during the sample collection process, and no long-term follow-up or treatment is involved. The study provides an opportunity for volunteers to contribute to advancing imaging techniques for better VTE diagnosis without impacting their usual medical care.

Molecular Imaging of Active Venous Thrombus With Positron Emission Tomography (PET)