Actively Recruiting
Molecular Phenotyping of Migraine Patients by Age and Sex Through CGRP Quantification in Saliva for Precision Medicine: FAST Study
Led by Hospital Universitari Vall d'Hebron Research Institute · Updated on 2024-11-13
440
Participants Needed
1
Research Sites
N/A
Total Duration
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AI-Summary
What this Trial Is About
Researchers are studying migraine patients and healthy controls to understand differences in CGRP levels, a neuropeptide linked to migraine. The study aims to explore how these differences relate to treatment responses by examining saliva and blood samples. Participants include males and females aged 6 to 75 years, with and without migraine, to compare molecular profiles. Participants will visit the study center twice: the first visit involves clinical assessment for migraine patients, and the second visit is for collecting saliva and blood samples. Healthy controls only attend the sample collection visit. The saliva samples will be tested for CGRP levels, while blood samples will be used for DNA and hormone testing. During the study, researchers will measure CGRP levels, hormone levels, and DNA markers over about one year. Participants' health and sample collection will be monitored to support understanding of migraine biology. The total participation involves up to two study visits focused on assessments and sample collection, with no treatment administered during the study.
CONDITIONS
Brief Title
Molecular Phenotyping of Migraine Patients According to Sex and Age Through CGRP Quantification
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Migraine patients diagnosed according to ICHD-3 criteria
- Healthy controls matched by age and sex without headache
- Healthy controls without first-degree family history of headache
You will not qualify if you...
- Presence of any major medical or neurological illness
- Presence of any salivary gland malfunction
- Abuse or dependence on tobacco, alcohol, or drugs in the past 12 months
- Current use of active migraine preventive treatment
- Pregnant or breastfeeding females
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Duration - Up to 1 year
Participants provide saliva and blood samples to measure CGRP, DNA, and hormone levels.
1 to 2 visits depending on cohort assignment
Trial Site Locations
Total: 1 location
1
Vall d'Hebron University Hospital
Barcelona, Barcelona, Spain, 08035
Actively Recruiting
Research Team
P
Patricia Pozo-Rosich, MD, PhD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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