Actively Recruiting
Molecular Profiling for Risk Stratification in Appendiceal Cancer
Led by City of Hope Medical Center · Updated on 2026-05-14
400
Participants Needed
1
Research Sites
35 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study investigates integrated epigenetic and epitranscriptomic features of appendiceal cancer using archived tumor tissue specimens from the same patient cohort. The study includes DNA methylation profiling and m6A epitranscriptomic profiling to define molecular subtypes, evaluate associations with clinicopathologic features, and develop molecular risk scores for prognostic stratification. The primary goal is to determine whether DNA methylation- and m6A-based molecular features can complement conventional histopathologic grading and improve risk stratification.
CONDITIONS
Official Title
Molecular Profiling for Risk Stratification in Appendiceal Cancer
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients with histologically confirmed appendiceal adenocarcinoma or appendiceal cancer
- Availability of archived tumor tissue suitable for molecular profiling
- Availability of tissue for DNA methylation profiling, m6A epitranscriptomic profiling, or both
- Availability of relevant clinicopathologic data
- Availability of survival or follow-up information when applicable
- Age 18 years or older at diagnosis or tissue collection
You will not qualify if you...
- Insufficient tissue quantity or quality for molecular profiling
- Inadequate DNA or RNA quality for sequencing or molecular assay preparation
- Missing essential clinicopathologic information required for analysis
- Non-appendiceal primary tumor or metastatic tumor to the appendix from another primary site
- Patients who do not meet institutional review board or consent requirements, if applicable
AI-Screening
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Trial Site Locations
Total: 1 location
1
City of Hope Medical Center
Duarte, California, United States, 91016
Actively Recruiting
Research Team
A
Ajay Goel
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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