Multi-Center Study Using MRI to Predict Key Genes and Outcomes in Adults with High-Grade Gliomas

What this Trial Is About

Researchers are exploring the use of multi-dimensional MRI imaging to understand how variations in high-grade gliomas, a type of aggressive brain tumor, relate to genetic mutations and patient outcomes. This study includes both a retrospective analysis of existing patient data and a prospective follow-up to examine how MRI features correlate with prognosis. The goal is to develop a model that helps predict patient survival and response to treatment based on tumor imaging and genetics. The study involves two groups a retrospective cohort with confirmed high-grade gliomas who had preoperative MRI and detailed clinical and genetic data, and a prospective cohort of patients suspected of having high-grade gliomas who will undergo multimodal MRI before surgery. After surgery, prospective participants receive standard radiotherapy and chemotherapy and are followed regularly. The MRI scans focus on spatial heterogeneity, capturing detailed tumor characteristics to analyze tumor diversity and evolution over time. Participants will be involved through MRI scanning and clinical data collection, with the prospective group undergoing a 40-minute MRI scan before surgery. Researchers will monitor survival prediction using imaging features and genetic information between 2025 and 2026. The study will also use time-dependent analysis to evaluate the accuracy of the survival predictions. Overall, participants contribute imaging and clinical information for advancing understanding of glioma heterogeneity and prognosis.

Multi-Dimensional MRI Spatial Heterogeneity Analysis for Predicting Key Genes and Prognosis of High-Grade Gliomas: A Multi-Center Study