Actively Recruiting
Multi-Dimensional MRI Spatial Heterogeneity Analysis for Predicting Key Genes and Prognosis of High-Grade Gliomas: A Multi-Center Study
Led by RenJi Hospital · Updated on 2025-08-08
500
Participants Needed
2
Research Sites
226 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
1. To retrospectively explore the feasibility of multi-dimensional heterogeneity imaging features of MRI in predicting the status of key gene mutations in high-grade gliomas; 2. To prospectively explore the correlation between multi-dimensional heterogeneous MRI image features and prognosis of high-grade glioma patients.
CONDITIONS
Official Title
Multi-Dimensional MRI Spatial Heterogeneity Analysis for Predicting Key Genes and Prognosis of High-Grade Gliomas: A Multi-Center Study
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Participants aged 18 to 70 years, of any gender
- Confirmed postoperative pathology of adult diffuse glioma (WHO Grade III-IV) for retrospective study
- Standard MR contrast-enhanced imaging performed within 10 days before surgery for retrospective study
- No prior radiotherapy or chemotherapy before surgery for retrospective study
- No significant comorbidities or other tumors
- Molecular testing results available (IDH, MGMT, 1p19q, TERT, CDKN2A/B, BRAF) for retrospective study
- Comprehensive clinical and follow-up data available for retrospective study
- Clinically suspected high-grade gliomas preoperatively, with final pathology confirming diagnosis for prospective study
- Stable vital signs and ability to cooperate for a 40-minute MR scan for prospective study
- Signed informed consent for prospective study
You will not qualify if you...
- MRI images with artifacts or intratumoral hemorrhage for retrospective study
- Incomplete clinical data for retrospective study
- Claustrophobia or inability to undergo MRI scans for prospective study
- History of allergic reactions to MRI contrast agents for prospective study
- Unsuitability for prolonged MRI scans due to other reasons for prospective study
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
Department of Radiology, Renji Hospital School of Medicine, Shanghai Jiao Tong University
Shanghai, Select A State Or Province, China, 200127
Actively Recruiting
2
Department of Radiology, Renji hospital, School of Medicine, Shanghai Jiao Tong University
Shanghai, Shanghai Municipality, China, 200127
Active, Not Recruiting
Research Team
Y
Yan Zhou, MD,PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here