Study of Tumor Biology and Progression in Adults with Metastatic Adenoid Cystic Carcinoma of the Head and Neck Using Multi-omics Analysis

What this Trial Is About

Researchers are investigating metastatic adenoid cystic carcinoma ACC of the head and neck to understand why some people have slow-growing tumors while others have faster or more aggressive disease. The study focuses on how the tumors biology relates to clinical risk groups defined by a published prediction tool called a nomogram. The main goal is to see if people in high-risk and low-risk groups have different tumor types ACC-I and ACC-II when their original tumor is tested. Additional questions include whether metastatic tumors share the same biology, how tumor types vary with metastasis location and timing, and if tumor biology relates to treatment response. This observational study involves collecting and analyzing biological samples without providing any treatment. Researchers will use stored tumor tissue collected during standard care and ask participants for blood samples at study entry and every six months for up to two years. Laboratory tests on these samples will examine gene activity, DNA fragments, DNA methylation, and circulating microRNAs. Computer-based digital analysis of tumor slides will help identify biological patterns. Participants will continue their usual medical treatments and follow-ups as decided by their own care teams. Participants will provide consent to use past tumor tissue and give blood samples during the study. Researchers will collect clinical and biological data to compare tumor and blood markers and understand tumor behavior over time. The main outcome is studying the link between clinical risk groups and tumor biology over 24 months. Secondary outcomes include assessing tumor biology in metastases, its variation by location and timing, and its association with treatment response. About 114 adults with metastatic ACC of the head and neck will participate, and the study will last up to two years with no study treatments given.

A Multi-omics Approach to Disclose Progression and Underlying Biology of Head and Neck Adenoid Cystic Carcinoma