New Approach Using Multi-Parametric MRI and Same-Day Bladder Biopsy for Diagnosing Muscle-Invasive Bladder Cancer Compared to Standard Bladder Tumor Removal

What this Trial Is About

Researchers are evaluating two diagnostic approaches for patients suspected of having muscle-invasive bladder cancer MIBC. This trial compares the standard care method, Transurethral Resection of the Bladder Tumor TURBT, with a newer approach using multiparametric MRI mpMRI followed by a same-day cystoscopic bladder biopsy. The study aims to assess progression-free survival, time to definitive treatment, and cost-effectiveness over two years. Participants will be randomly assigned to one of two groups one undergoing mpMRI plus same-day cystoscopic bladder biopsy, and the other receiving TURBT with blood samples taken shortly before and after the procedure. Both groups will be monitored and compared for their diagnostic outcomes and related healthcare costs. Throughout the study, participants will have regular evaluations including assessments of progression-free survival, quality of life, healthcare costs, and circulating tumor cells before and after TURBT. The main outcome measure is progression-free survival at two years. The study involves multiple centers and aims to provide detailed information on the effectiveness and cost implications of these diagnostic strategies.

Multi-parametric MRI in Patients Suspected for Muscle Invasive Bladder Cancer: a New Local Staging Paradigm