Actively Recruiting
Multimodality Evaluation of Left Ventricular Remodeling In Mitral Regurgitation: A Pilot Study
Led by Mayo Clinic · Updated on 2026-03-03
30
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating a multimodal approach using cardiac CT and MRI to assess the risk of developing left ventricular systolic dysfunction in patients with severe chronic primary mitral regurgitation. This pilot study aims to determine the feasibility of a larger future study focused on this heart condition. The study is observational and sponsored by Mayo Clinic. Adults with severe chronic primary mitral regurgitation who are undergoing robotic mitral annuloplasty at Mayo Clinic Rochester will be included. Each participant will receive two cardiac MRI scans: one before surgery and another 6 to 12 months after surgery. Each MRI takes approximately 45 to 60 minutes. The study will observe participants over a two-year period. Participants will be monitored for recruitment and dropout rates, as well as the development of systolic dysfunction during the two years. The study involves consent procedures and MRI scans with and without contrast. Pregnancy status and implantable device compatibility with MRI will be assessed. Data collected will help evaluate left ventricular remodeling and function after the surgical procedure.
CONDITIONS
Brief Title
Multimodality Evaluation of Left Ventricular Remodeling In Mitral Regurgitation: A Pilot Study
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age �3e= 18
- Male or Female
- A diagnosis of severe chronic primary mitral regurgitation
- Undergoing isolated robotic mitral annuloplasty at Mayo Clinic Rochester
- Ability to consent or have an appropriate representative available to consent
You will not qualify if you...
- Prior valve intervention
- Concomitant valve surgery at the time of mitral annuloplasty (e.g. tricuspid annuloplasty, aortic valve replacement)
- Moderate or greater regurgitation or stenosis in any other valve by preoperative echocardiography
- History of prior myocardial infarction
- History of cardiomyopathy unrelated to mitral regurgitation (e.g. dilated, hypertrophic, infiltrative)
- Pregnancy
- Implantable devices that are contraindications to MRI
- Severe allergy to gadolinium MRI contrast
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Preoperative period
Participants undergo cardiac MRI scans before surgery to evaluate left ventricular remodeling.
1 visit (in-person)
Duration - Surgical procedure day
Participants undergo robotic mitral annuloplasty at Mayo Clinic Rochester.
1 visit (in-person)
Duration - 6 to 12 months after surgery
Participants receive follow-up cardiac MRI scans 6 to 12 months after surgery to assess changes in left ventricular remodeling.
1 visit (in-person)
Duration - Up to 2 years
Participants are monitored for outcomes related to systolic function and overall cardiac health for up to 2 years.
Periodic assessments may occur during follow-up
Trial Site Locations
Total: 1 location
1
Mayo Clinic
Rochester, Minnesota, United States, 55905
Actively Recruiting
Research Team
C
Cardiovascular Surgical Research
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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