Comparing Nasal Swab and Modified Valsalva Maneuver for Treating Supraventricular Tachycardia in Adults

What this Trial Is About

Researchers are evaluating treatments for supraventricular tachycardia SVT, a common heart rhythm disorder that causes a rapid heartbeat. The study compares a nasal swab technique with the modified Valsalva maneuver, the current best non-drug treatment, to see which better restores normal heart rhythm within one minute. This trial is conducted in two phases a pilot phase to test feasibility and gather data, followed by a main phase to finalize participant numbers based on pilot results. Participants are randomly assigned to one of two groups. One group receives a standard nasopharyngeal swab inserted through the nostril and held for 10 seconds while monitored. The other group performs the modified Valsalva maneuver, involving a forced expiration into a syringe followed by rapid repositioning and leg elevation. If the assigned method fails, intravenous adenosine is given as rescue therapy. The study is open-label for patients and care providers but has blinded outcome assessment and statistical analysis. During the study, participants are continuously monitored with heart rhythm, oxygen levels, and blood pressure checks. Researchers assess whether normal heart rhythm is restored within one minute and also measure outcomes at 3 and 5 minutes, patient discomfort, satisfaction, and recurrence of SVT at 24 hours and 30 days. Safety is closely monitored, and participants are followed up for 30 days to observe any adverse events or recurrence.

NASVAL-SVT: Nasal Swab Versus Modified Valsalva for Supraventricular Tachycardia