Actively Recruiting
A Randomized Controlled Trial Comparing Nasal Swab and Modified Valsalva Maneuver for the Treatment of Supraventricular Tachycardia
Led by Marmara University Pendik Training and Research Hospital · Updated on 2026-06-01
60
Participants Needed
1
Research Sites
4 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating treatments for supraventricular tachycardia (SVT), a common heart rhythm disorder that causes a rapid heartbeat. The study compares a nasal swab technique with the modified Valsalva maneuver, the current best non-drug treatment, to see which better restores normal heart rhythm within one minute. This trial is conducted in two phases: a pilot phase to test feasibility and gather data, followed by a main phase to finalize participant numbers based on pilot results. Participants are randomly assigned to one of two groups. One group receives a standard nasopharyngeal swab inserted through the nostril and held for 10 seconds while monitored. The other group performs the modified Valsalva maneuver, involving a forced expiration into a syringe followed by rapid repositioning and leg elevation. If the assigned method fails, intravenous adenosine is given as rescue therapy. The study is open-label for patients and care providers but has blinded outcome assessment and statistical analysis. During the study, participants are continuously monitored with heart rhythm, oxygen levels, and blood pressure checks. Researchers assess whether normal heart rhythm is restored within one minute and also measure outcomes at 3 and 5 minutes, patient discomfort, satisfaction, and recurrence of SVT at 24 hours and 30 days. Safety is closely monitored, and participants are followed up for 30 days to observe any adverse events or recurrence.
CONDITIONS
Brief Title
NASVAL-SVT: Nasal Swab Versus Modified Valsalva for Supraventricular Tachycardia
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- Confirmed supraventricular tachycardia diagnosis by ECG with narrow QRS complex and regular rhythm
- Hemodynamically stable with systolic blood pressure of at least 90 mmHg and diastolic blood pressure of at least 60 mmHg
- Alert and oriented mental status (Glasgow Coma Scale 15)
- No signs of acute organ dysfunction
- Ability and willingness to provide written informed consent
You will not qualify if you...
- Age under 18 years
- Known or suspected pregnancy
- Unable to confirm SVT diagnosis by ECG criteria
- Presence of delta wave or pre-excitation pattern on ECG (e.g., Wolff-Parkinson-White syndrome)
- Wide QRS tachycardia where ventricular tachycardia cannot be excluded
- Absolute contraindication to modified Valsalva maneuver (unable to lie supine or elevate legs)
- Contraindication to nasal swab (nasal surgery within last 30 days, active nosebleed, visible nasal polyp or mass)
- Hemodynamic instability needing immediate cardioversion
- Prior enrollment in this study
- Refusal to participate
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Single session lasting approximately 30 seconds to 1 minute
Participants receive one of two treatment procedures to terminate supraventricular tachycardia: either a nasal swab insertion held for 10 seconds or a modified Valsalva maneuver involving forced expiration followed by repositioning and leg elevation. Rescue therapy with intravenous adenosine is provided if the initial procedure fails.
1 treatment visit (in-person)
Duration - Up to 30 days after treatment
Participants are monitored for adverse events and treatment outcomes including heart rhythm conversion and recurrence of supraventricular tachycardia up to 30 days after the procedure.
Follow-up assessments at 24 hours and 30 days post-procedure
Trial Site Locations
Total: 1 location
1
Marmara University Pendik Training and Research Hospital
Istanbul, Pendik, Turkey (Türkiye), 34899
Actively Recruiting
Research Team
E
Emir Ünal
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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